1QR7
CRYSTAL STRUCTURE OF PHENYLALANINE-REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE FROM ESCHERICHIA COLI COMPLEXED WITH PB2+ AND PEP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0042802 | molecular_function | identical protein binding |
| C | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0042802 | molecular_function | identical protein binding |
| D | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0009423 | biological_process | chorismate biosynthetic process |
| D | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PB A 351 |
| Chain | Residue |
| A | CYS61 |
| A | HIS268 |
| A | GLU302 |
| A | ASP326 |
| A | PEP1352 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PB B 351 |
| Chain | Residue |
| B | PEP2352 |
| B | CYS61 |
| B | HIS268 |
| B | GLU302 |
| B | ASP326 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PB C 351 |
| Chain | Residue |
| C | CYS61 |
| C | HIS268 |
| C | GLU302 |
| C | ASP326 |
| C | PEP3352 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PB D 351 |
| Chain | Residue |
| D | CYS61 |
| D | HIS268 |
| D | GLU302 |
| D | ASP326 |
| D | PEP4352 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1353 |
| Chain | Residue |
| A | ARG99 |
| A | THR100 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2353 |
| Chain | Residue |
| B | ARG99 |
| B | THR100 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 3353 |
| Chain | Residue |
| C | ARG99 |
| C | THR100 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 4353 |
| Chain | Residue |
| D | ARG99 |
| D | THR100 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEP A 1352 |
| Chain | Residue |
| A | ARG92 |
| A | TYR94 |
| A | LYS97 |
| A | GLY163 |
| A | ALA164 |
| A | ARG165 |
| A | LYS186 |
| A | ARG234 |
| A | HIS268 |
| A | PB351 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEP B 2352 |
| Chain | Residue |
| B | ARG92 |
| B | TYR94 |
| B | LYS97 |
| B | GLY163 |
| B | ALA164 |
| B | ARG165 |
| B | LYS186 |
| B | ARG234 |
| B | HIS268 |
| B | PB351 |
| site_id | BC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEP C 3352 |
| Chain | Residue |
| C | ARG92 |
| C | TYR94 |
| C | LYS97 |
| C | GLY163 |
| C | ALA164 |
| C | ARG165 |
| C | LYS186 |
| C | ARG234 |
| C | HIS268 |
| C | PB351 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEP D 4352 |
| Chain | Residue |
| D | ARG92 |
| D | TYR94 |
| D | LYS97 |
| D | GLY163 |
| D | ALA164 |
| D | ARG165 |
| D | LYS186 |
| D | ARG234 |
| D | HIS268 |
| D | PB351 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01406","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| A | HIS268 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| B | HIS268 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| C | HIS268 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| D | HIS268 |
