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1QPF

FK506 BINDING PROTEIN (12 KDA, HUMAN) COMPLEX WITH L-709,858

Functional Information from GO Data
ChainGOidnamespacecontents
A0003007biological_processheart morphogenesis
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005246molecular_functioncalcium channel regulator activity
A0005515molecular_functionprotein binding
A0005527molecular_functionmacrolide binding
A0005528molecular_functionFK506 binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006457biological_processprotein folding
A0006458biological_process'de novo' protein folding
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0014802cellular_componentterminal cisterna
A0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0016853molecular_functionisomerase activity
A0030018cellular_componentZ disc
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0030547molecular_functionsignaling receptor inhibitor activity
A0032880biological_processregulation of protein localization
A0032926biological_processnegative regulation of activin receptor signaling pathway
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034713molecular_functiontype I transforming growth factor beta receptor binding
A0042026biological_processprotein refolding
A0042110biological_processT cell activation
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0050776biological_processregulation of immune response
A0051604biological_processprotein maturation
A0055010biological_processventricular cardiac muscle tissue morphogenesis
A0060347biological_processheart trabecula formation
A0070411molecular_functionI-SMAD binding
A0070697molecular_functionactivin receptor binding
A0097435biological_processsupramolecular fiber organization
A0098562cellular_componentcytoplasmic side of membrane
A1902991biological_processregulation of amyloid precursor protein catabolic process
A1990000biological_processamyloid fibril formation
A1990425cellular_componentryanodine receptor complex
D0003007biological_processheart morphogenesis
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
D0005160molecular_functiontransforming growth factor beta receptor binding
D0005246molecular_functioncalcium channel regulator activity
D0005515molecular_functionprotein binding
D0005527molecular_functionmacrolide binding
D0005528molecular_functionFK506 binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006457biological_processprotein folding
D0006458biological_process'de novo' protein folding
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0014802cellular_componentterminal cisterna
D0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0016853molecular_functionisomerase activity
D0030018cellular_componentZ disc
D0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
D0030547molecular_functionsignaling receptor inhibitor activity
D0032880biological_processregulation of protein localization
D0032926biological_processnegative regulation of activin receptor signaling pathway
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034713molecular_functiontype I transforming growth factor beta receptor binding
D0042026biological_processprotein refolding
D0042110biological_processT cell activation
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0044325molecular_functiontransmembrane transporter binding
D0050776biological_processregulation of immune response
D0051604biological_processprotein maturation
D0055010biological_processventricular cardiac muscle tissue morphogenesis
D0060347biological_processheart trabecula formation
D0070411molecular_functionI-SMAD binding
D0070697molecular_functionactivin receptor binding
D0097435biological_processsupramolecular fiber organization
D0098562cellular_componentcytoplasmic side of membrane
D1902991biological_processregulation of amyloid precursor protein catabolic process
D1990000biological_processamyloid fibril formation
D1990425cellular_componentryanodine receptor complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883
ChainResidueDetails
AGLN53
DGLN253

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1d6o
ChainResidueDetails
AILE56
ATYR82
AASP37

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1d6o
ChainResidueDetails
DASP237
DTYR282
DILE256

site_idMCSA1
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
ATYR26electrostatic destabiliser, steric role
APHE36electrostatic destabiliser, polar/non-polar interaction, steric role
AASP37electrostatic stabiliser, steric role
AILE56electrostatic stabiliser, steric role
ATYR82electrostatic stabiliser, steric role
APHE99electrostatic destabiliser, polar/non-polar interaction, steric role

site_idMCSA2
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails

237735

PDB entries from 2025-06-18

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