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1QO1

Molecular Architecture of the Rotary Motor in ATP Synthase from Yeast Mitochondria

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
A0005754cellular_componentmitochondrial proton-transporting ATP synthase, catalytic core
A0005886cellular_componentplasma membrane
A0006754biological_processATP biosynthetic process
A0006811biological_processmonoatomic ion transport
A0015986biological_processproton motive force-driven ATP synthesis
A0016020cellular_componentmembrane
A0032559molecular_functionadenyl ribonucleotide binding
A0043531molecular_functionADP binding
A0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
A0046034biological_processATP metabolic process
A0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
A1902600biological_processproton transmembrane transport
B0000166molecular_functionnucleotide binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
B0005754cellular_componentmitochondrial proton-transporting ATP synthase, catalytic core
B0005886cellular_componentplasma membrane
B0006754biological_processATP biosynthetic process
B0006811biological_processmonoatomic ion transport
B0015986biological_processproton motive force-driven ATP synthesis
B0016020cellular_componentmembrane
B0032559molecular_functionadenyl ribonucleotide binding
B0043531molecular_functionADP binding
B0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
B0046034biological_processATP metabolic process
B0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
B1902600biological_processproton transmembrane transport
C0000166molecular_functionnucleotide binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
C0005754cellular_componentmitochondrial proton-transporting ATP synthase, catalytic core
C0005886cellular_componentplasma membrane
C0006754biological_processATP biosynthetic process
C0006811biological_processmonoatomic ion transport
C0015986biological_processproton motive force-driven ATP synthesis
C0016020cellular_componentmembrane
C0032559molecular_functionadenyl ribonucleotide binding
C0043531molecular_functionADP binding
C0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
C0046034biological_processATP metabolic process
C0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
C1902600biological_processproton transmembrane transport
D0000166molecular_functionnucleotide binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
D0006754biological_processATP biosynthetic process
D0006811biological_processmonoatomic ion transport
D0015986biological_processproton motive force-driven ATP synthesis
D0016020cellular_componentmembrane
D0016887molecular_functionATP hydrolysis activity
D0042776biological_processproton motive force-driven mitochondrial ATP synthesis
D0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
D0046034biological_processATP metabolic process
D0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
D0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
D1902600biological_processproton transmembrane transport
E0000166molecular_functionnucleotide binding
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005743cellular_componentmitochondrial inner membrane
E0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
E0006754biological_processATP biosynthetic process
E0006811biological_processmonoatomic ion transport
E0015986biological_processproton motive force-driven ATP synthesis
E0016020cellular_componentmembrane
E0016887molecular_functionATP hydrolysis activity
E0042776biological_processproton motive force-driven mitochondrial ATP synthesis
E0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
E0046034biological_processATP metabolic process
E0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
E0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
E1902600biological_processproton transmembrane transport
F0000166molecular_functionnucleotide binding
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005743cellular_componentmitochondrial inner membrane
F0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
F0006754biological_processATP biosynthetic process
F0006811biological_processmonoatomic ion transport
F0015986biological_processproton motive force-driven ATP synthesis
F0016020cellular_componentmembrane
F0016887molecular_functionATP hydrolysis activity
F0042776biological_processproton motive force-driven mitochondrial ATP synthesis
F0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
F0046034biological_processATP metabolic process
F0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
F0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
F1902600biological_processproton transmembrane transport
G0000275cellular_componentmitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
G0005515molecular_functionprotein binding
G0005739cellular_componentmitochondrion
G0005743cellular_componentmitochondrial inner membrane
G0005753cellular_componentmitochondrial proton-transporting ATP synthase complex
G0006754biological_processATP biosynthetic process
G0006811biological_processmonoatomic ion transport
G0015986biological_processproton motive force-driven ATP synthesis
G0016020cellular_componentmembrane
G0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
G0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
G1902600biological_processproton transmembrane transport
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005886cellular_componentplasma membrane
J0006754biological_processATP biosynthetic process
J0006811biological_processmonoatomic ion transport
J0015986biological_processproton motive force-driven ATP synthesis
J0016020cellular_componentmembrane
J0042777biological_processproton motive force-driven plasma membrane ATP synthesis
J0045259cellular_componentproton-transporting ATP synthase complex
J0045261cellular_componentproton-transporting ATP synthase complex, catalytic core F(1)
J0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
J1902600biological_processproton transmembrane transport
K0005886cellular_componentplasma membrane
K0006754biological_processATP biosynthetic process
K0006811biological_processmonoatomic ion transport
K0008289molecular_functionlipid binding
K0015078molecular_functionproton transmembrane transporter activity
K0015986biological_processproton motive force-driven ATP synthesis
K0016020cellular_componentmembrane
K0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
K0042777biological_processproton motive force-driven plasma membrane ATP synthesis
K0045259cellular_componentproton-transporting ATP synthase complex
K0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
K0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
K0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
K1902600biological_processproton transmembrane transport
L0005886cellular_componentplasma membrane
L0006754biological_processATP biosynthetic process
L0006811biological_processmonoatomic ion transport
L0008289molecular_functionlipid binding
L0015078molecular_functionproton transmembrane transporter activity
L0015986biological_processproton motive force-driven ATP synthesis
L0016020cellular_componentmembrane
L0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
L0042777biological_processproton motive force-driven plasma membrane ATP synthesis
L0045259cellular_componentproton-transporting ATP synthase complex
L0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
L0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
L0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
L1902600biological_processproton transmembrane transport
M0005886cellular_componentplasma membrane
M0006754biological_processATP biosynthetic process
M0006811biological_processmonoatomic ion transport
M0008289molecular_functionlipid binding
M0015078molecular_functionproton transmembrane transporter activity
M0015986biological_processproton motive force-driven ATP synthesis
M0016020cellular_componentmembrane
M0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
M0042777biological_processproton motive force-driven plasma membrane ATP synthesis
M0045259cellular_componentproton-transporting ATP synthase complex
M0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
M0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
M0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
M1902600biological_processproton transmembrane transport
N0005886cellular_componentplasma membrane
N0006754biological_processATP biosynthetic process
N0006811biological_processmonoatomic ion transport
N0008289molecular_functionlipid binding
N0015078molecular_functionproton transmembrane transporter activity
N0015986biological_processproton motive force-driven ATP synthesis
N0016020cellular_componentmembrane
N0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
N0042777biological_processproton motive force-driven plasma membrane ATP synthesis
N0045259cellular_componentproton-transporting ATP synthase complex
N0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
N0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
N0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
N1902600biological_processproton transmembrane transport
O0005886cellular_componentplasma membrane
O0006754biological_processATP biosynthetic process
O0006811biological_processmonoatomic ion transport
O0008289molecular_functionlipid binding
O0015078molecular_functionproton transmembrane transporter activity
O0015986biological_processproton motive force-driven ATP synthesis
O0016020cellular_componentmembrane
O0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
O0042777biological_processproton motive force-driven plasma membrane ATP synthesis
O0045259cellular_componentproton-transporting ATP synthase complex
O0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
O0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
O0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
O1902600biological_processproton transmembrane transport
P0005886cellular_componentplasma membrane
P0006754biological_processATP biosynthetic process
P0006811biological_processmonoatomic ion transport
P0008289molecular_functionlipid binding
P0015078molecular_functionproton transmembrane transporter activity
P0015986biological_processproton motive force-driven ATP synthesis
P0016020cellular_componentmembrane
P0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
P0042777biological_processproton motive force-driven plasma membrane ATP synthesis
P0045259cellular_componentproton-transporting ATP synthase complex
P0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
P0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
P0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
P1902600biological_processproton transmembrane transport
Q0005886cellular_componentplasma membrane
Q0006754biological_processATP biosynthetic process
Q0006811biological_processmonoatomic ion transport
Q0008289molecular_functionlipid binding
Q0015078molecular_functionproton transmembrane transporter activity
Q0015986biological_processproton motive force-driven ATP synthesis
Q0016020cellular_componentmembrane
Q0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
Q0042777biological_processproton motive force-driven plasma membrane ATP synthesis
Q0045259cellular_componentproton-transporting ATP synthase complex
Q0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
Q0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
Q0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
Q1902600biological_processproton transmembrane transport
R0005886cellular_componentplasma membrane
R0006754biological_processATP biosynthetic process
R0006811biological_processmonoatomic ion transport
R0008289molecular_functionlipid binding
R0015078molecular_functionproton transmembrane transporter activity
R0015986biological_processproton motive force-driven ATP synthesis
R0016020cellular_componentmembrane
R0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
R0042777biological_processproton motive force-driven plasma membrane ATP synthesis
R0045259cellular_componentproton-transporting ATP synthase complex
R0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
R0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
R0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
R1902600biological_processproton transmembrane transport
S0005886cellular_componentplasma membrane
S0006754biological_processATP biosynthetic process
S0006811biological_processmonoatomic ion transport
S0008289molecular_functionlipid binding
S0015078molecular_functionproton transmembrane transporter activity
S0015986biological_processproton motive force-driven ATP synthesis
S0016020cellular_componentmembrane
S0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
S0042777biological_processproton motive force-driven plasma membrane ATP synthesis
S0045259cellular_componentproton-transporting ATP synthase complex
S0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
S0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
S0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
S1902600biological_processproton transmembrane transport
T0005886cellular_componentplasma membrane
T0006754biological_processATP biosynthetic process
T0006811biological_processmonoatomic ion transport
T0008289molecular_functionlipid binding
T0015078molecular_functionproton transmembrane transporter activity
T0015986biological_processproton motive force-driven ATP synthesis
T0016020cellular_componentmembrane
T0033177cellular_componentproton-transporting two-sector ATPase complex, proton-transporting domain
T0042777biological_processproton motive force-driven plasma membrane ATP synthesis
T0045259cellular_componentproton-transporting ATP synthase complex
T0045263cellular_componentproton-transporting ATP synthase complex, coupling factor F(o)
T0046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
T0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
T1902600biological_processproton transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00153
Number of Residues14
DetailsATPASE_GAMMA ATP synthase gamma subunit signature. ITkEliEiisGAaA
ChainResidueDetails
GILE258-ALA271

site_idPS00152
Number of Residues10
DetailsATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSTS
ChainResidueDetails
DPRO346-SER355
APRO363-SER372

site_idPS00605
Number of Residues22
DetailsATPASE_C ATP synthase c subunit signature. ARQPdliplLrTqfFIvmgLvD
ChainResidueDetails
KALA40-ASP61

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues400
DetailsTRANSMEM: Helical
ChainResidueDetails
MPHE53-TYR73
KMET11-LEU31
KPHE53-TYR73
LMET11-LEU31
LPHE53-TYR73
MMET11-LEU31
NMET11-LEU31
NPHE53-TYR73
OMET11-LEU31
OPHE53-TYR73
PMET11-LEU31
PPHE53-TYR73
QMET11-LEU31
QPHE53-TYR73
RMET11-LEU31
RPHE53-TYR73
SMET11-LEU31
SPHE53-TYR73
TMET11-LEU31
TPHE53-TYR73

site_idSWS_FT_FI2
Number of Residues10
DetailsSITE: Reversibly protonated during proton transport
ChainResidueDetails
KASP61
LASP61
MASP61
NASP61
OASP61
PASP61
QASP61
RASP61
SASP61
TASP61

site_idSWS_FT_FI3
Number of Residues10
DetailsMOD_RES: N-formylmethionine => ECO:0000250
ChainResidueDetails
KMET1
LMET1
MMET1
NMET1
OMET1
PMET1
QMET1
RMET1
SMET1
TMET1
FLYS74
FLYS111
FLYS209
FLYS214
FLYS472

site_idSWS_FT_FI4
Number of Residues140
DetailsTOPO_DOM: Periplasmic
ChainResidueDetails
RVAL74-ALA79
SMET1-TYR10
SVAL74-ALA79
TMET1-TYR10
TVAL74-ALA79
PMET1-TYR10
PVAL74-ALA79
RMET1-TYR10
KMET1-TYR10
KVAL74-ALA79
LMET1-TYR10
LVAL74-ALA79
MMET1-TYR10
MVAL74-ALA79
NMET1-TYR10
NVAL74-ALA79
OMET1-TYR10
OVAL74-ALA79
QMET1-TYR10
QVAL74-ALA79

site_idSWS_FT_FI5
Number of Residues200
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
MGLY32-GLN52
QGLY32-GLN52
RGLY32-GLN52
SGLY32-GLN52
TGLY32-GLN52
KGLY32-GLN52
LGLY32-GLN52
NGLY32-GLN52
OGLY32-GLN52
PGLY32-GLN52

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06576
ChainResidueDetails
DSER365
ESER365
FSER365

site_idSWS_FT_FI7
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10719
ChainResidueDetails
DSER383
FSER383
ALYS197
ALYS498
BLYS80
BLYS83
BLYS89
BLYS197
BLYS498
CLYS80
CLYS83
CLYS89
CLYS197
CLYS498
ESER383

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P56480
ChainResidueDetails
DLYS430
DLYS435
ELYS430
ELYS435
FLYS430
FLYS435

site_idSWS_FT_FI9
Number of Residues3
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250
ChainResidueDetails
DSER56
FSER56
ALYS196
ALYS218
ALYS262
ALYS384
ALYS455
ALYS463
ALYS488
ALYS496
BLYS118
BLYS124
BLYS187
BLYS196
BLYS218
BLYS262
BLYS384
BLYS455
BLYS463
BLYS488
BLYS496
CLYS118
CLYS124
CLYS187
CLYS196
CLYS218
CLYS262
CLYS384
CLYS455
CLYS463
CLYS488
CLYS496
ESER56

site_idSWS_FT_FI10
Number of Residues3
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q03265
ChainResidueDetails
CARG161
AARG161
BARG161

site_idSWS_FT_FI11
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P25705
ChainResidueDetails
ALYS391
BLYS391
CLYS391

site_idSWS_FT_FI12
Number of Residues3
DetailsCARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250
ChainResidueDetails
ASER33
BSER33
CSER33

Catalytic Information from CSA
site_idMCSA1
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
KASP61electrostatic stabiliser, proton acceptor, proton donor
DGLU188electrostatic stabiliser
DARG189electrostatic stabiliser

site_idMCSA2
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
LASP61electrostatic stabiliser, proton acceptor, proton donor
EGLU188electrostatic stabiliser
EARG189electrostatic stabiliser

site_idMCSA3
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
MASP61electrostatic stabiliser, proton acceptor, proton donor
FGLU188electrostatic stabiliser
FARG189electrostatic stabiliser

site_idMCSA4
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
NASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA5
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
OASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA6
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
PASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA7
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
QASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA8
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
RASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA9
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
SASP61electrostatic stabiliser, proton acceptor, proton donor

site_idMCSA10
Number of Residues1
DetailsM-CSA 507
ChainResidueDetails
TASP61electrostatic stabiliser, proton acceptor, proton donor

218500

PDB entries from 2024-04-17

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