1QNT
X-ray structure of human O6alkylguanine-DNA alkyltransferase
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00374 |
| Number of Residues | 7 |
| Details | MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV |
| Chain | Residue | Details |
| A | ILE143-VAL149 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GLHEIKLLGKG |
| Chain | Residue | Details |
| A | GLY27-GLY37 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; methyl group acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10747039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15964013","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eh6 |
| Chain | Residue | Details |
| A | GLU172 | |
| A | CYS145 | |
| A | ASN137 | |
| A | HIS146 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 251 |
| Chain | Residue | Details |
| A | TYR114 | hydrogen bond donor, proton donor |
| A | ASN137 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | CYS145 | hydrogen bond donor, nucleophile, proton donor |
| A | HIS146 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor |
| A | GLU172 | hydrogen bond acceptor, increase basicity |
