Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1QMG

Acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxy-methylvalerate, manganese and ADP-ribose.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004455	molecular_function	ketol-acid reductoisomerase activity
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
B	0004455	molecular_function	ketol-acid reductoisomerase activity
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
C	0004455	molecular_function	ketol-acid reductoisomerase activity
C	0009082	biological_process	branched-chain amino acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
D	0004455	molecular_function	ketol-acid reductoisomerase activity
D	0009082	biological_process	branched-chain amino acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 601

Chain	Residue
A	ASP315
A	GLU319
A	MN602
A	DMV620
A	HOH2664
A	HOH2665

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 602

Chain	Residue
A	HOH2666
A	HOH2667
A	HOH2668
A	ASP315
A	MN601
A	DMV620

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 603

Chain	Residue
A	ALA454
A	GLY455
A	HIS506
A	HOH2634
A	HOH2669
A	HOH2670
A	HOH2671
A	HOH2672
A	HOH2673
A	HOH2674

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 601

Chain	Residue
B	ASP315
B	GLU319
B	MN602
B	DMV620
B	HOH2533
B	HOH2534

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 602

Chain	Residue
B	ASP315
B	MN601
B	DMV620
B	HOH2535
B	HOH2536
B	HOH2537

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 601

Chain	Residue
C	ASP315
C	GLU319
C	MN602
C	DMV620
C	HOH2458
C	HOH2459

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 602

Chain	Residue
C	ASP315
C	MN601
C	DMV620
C	HOH2460
C	HOH2461
C	HOH2462

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 601

Chain	Residue
D	ASP315
D	GLU319
D	MN602
D	DMV620
D	HOH2408
D	HOH2409

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 602

Chain	Residue
D	ASP315
D	MN601
D	DMV620
D	HOH2410
D	HOH2411
D	HOH2412

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DMV A 620

Chain	Residue
A	GLY253
A	MET254
A	ASP315
A	GLU319
A	GLU496
A	CYS517
A	SER518
A	ALA521
A	MN601
A	MN602
A	HOH2675

site_id	BC2
Number of Residues	29
Details	BINDING SITE FOR RESIDUE APX A 600

Chain	Residue
A	GLY132
A	TRP133
A	GLY134
A	SER135
A	GLN136
A	ARG162
A	SER165
A	SER167
A	MET186
A	LEU199
A	ILE200
A	SER201
A	ASP202
A	ALA204
A	GLN205
A	HIS226
A	SER518
A	THR519
A	ARG589
A	HOH2656
A	HOH2657
A	HOH2658
A	HOH2659
A	HOH2660
A	HOH2661
A	HOH2662
A	HOH2663
A	HOH2664
A	HOH2675

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DMV B 620

Chain	Residue
B	ASP315
B	GLU319
B	GLU496
B	CYS517
B	SER518
B	ALA521
B	MN601
B	MN602
B	HOH2533
B	HOH2538
B	MET254

site_id	BC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE APX B 600

Chain	Residue
B	TRP133
B	GLY134
B	SER135
B	GLN136
B	ARG162
B	SER165
B	SER167
B	MET186
B	LEU199
B	ILE200
B	SER201
B	ASP202
B	ALA204
B	GLN205
B	HIS226
B	SER518
B	THR519
B	ARG589
B	HOH2096
B	HOH2523
B	HOH2524
B	HOH2525
B	HOH2526
B	HOH2527
B	HOH2528
B	HOH2529
B	HOH2530
B	HOH2531
B	HOH2532
B	HOH2533
B	HOH2538

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DMV C 620

Chain	Residue
C	MET254
C	ASP315
C	GLU319
C	GLU496
C	CYS517
C	SER518
C	ALA521
C	MN601
C	MN602
C	HOH2463

site_id	BC6
Number of Residues	31
Details	BINDING SITE FOR RESIDUE APX C 600

Chain	Residue
C	GLY132
C	TRP133
C	GLY134
C	SER135
C	GLN136
C	ARG162
C	SER165
C	SER167
C	MET186
C	LEU199
C	ILE200
C	SER201
C	ASP202
C	ALA204
C	GLN205
C	HIS226
C	SER518
C	THR519
C	ARG589
C	HOH2108
C	HOH2449
C	HOH2450
C	HOH2451
C	HOH2452
C	HOH2453
C	HOH2454
C	HOH2455
C	HOH2456
C	HOH2457
C	HOH2458
C	HOH2463

site_id	BC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DMV D 620

Chain	Residue
D	GLY253
D	MET254
D	ASP315
D	GLU319
D	GLU496
D	CYS517
D	SER518
D	ALA521
D	MN601
D	MN602
D	HOH2413

site_id	BC8
Number of Residues	29
Details	BINDING SITE FOR RESIDUE APX D 600

Chain	Residue
D	GLY132
D	TRP133
D	GLY134
D	SER135
D	GLN136
D	ARG162
D	SER165
D	SER167
D	MET186
D	LEU199
D	ILE200
D	SER201
D	ASP202
D	ALA204
D	GLN205
D	ASN208
D	HIS226
D	SER518
D	THR519
D	ARG589
D	HOH2072
D	HOH2115
D	HOH2403
D	HOH2404
D	HOH2405
D	HOH2406
D	HOH2407
D	HOH2409
D	HOH2413

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	792
Details	Domain: {"description":"KARI N-terminal Rossmann","evidences":[{"source":"PROSITE-ProRule","id":"PRU01197","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	592
Details	Domain: {"description":"KARI C-terminal knotted 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01198","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	544
Details	Domain: {"description":"KARI C-terminal knotted 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01198","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10739911","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9218783","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01198","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1yve

Chain	Residue	Details
A	GLU496

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1yve

Chain	Residue	Details
B	GLU496

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1yve

Chain	Residue	Details
C	GLU496

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1yve

Chain	Residue	Details
D	GLU496

site_id	MCSA1
Number of Residues	3
Details	M-CSA 890

Chain	Residue	Details
A	LYS252	proton acceptor, proton donor
A	ASP315	metal ligand
A	GLU319	metal ligand

site_id	MCSA2
Number of Residues	3
Details	M-CSA 890

Chain	Residue	Details
B	LYS252	proton acceptor, proton donor
B	ASP315	metal ligand
B	GLU319	metal ligand

site_id	MCSA3
Number of Residues	3
Details	M-CSA 890

Chain	Residue	Details
C	LYS252	proton acceptor, proton donor
C	ASP315	metal ligand
C	GLU319	metal ligand

site_id	MCSA4
Number of Residues	3
Details	M-CSA 890

Chain	Residue	Details
D	LYS252	proton acceptor, proton donor
D	ASP315	metal ligand
D	GLU319	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)