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1QLX

Human prion protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0001933biological_processnegative regulation of protein phosphorylation
A0002020molecular_functionprotease binding
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005521molecular_functionlamin binding
A0005539molecular_functionglycosaminoglycan binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006878biological_processintracellular copper ion homeostasis
A0006979biological_processresponse to oxidative stress
A0007049biological_processcell cycle
A0007611biological_processlearning or memory
A0007616biological_processlong-term memory
A0008017molecular_functionmicrotubule binding
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010955biological_processnegative regulation of protein processing
A0014069cellular_componentpostsynaptic density
A0015631molecular_functiontubulin binding
A0016020cellular_componentmembrane
A0016234cellular_componentinclusion body
A0019828molecular_functionaspartic-type endopeptidase inhibitor activity
A0019898cellular_componentextrinsic component of membrane
A0030425cellular_componentdendrite
A0031648biological_processprotein destabilization
A0031802molecular_functiontype 5 metabotropic glutamate receptor binding
A0031805molecular_functiontype 8 metabotropic glutamate receptor binding
A0031965cellular_componentnuclear membrane
A0032689biological_processnegative regulation of type II interferon production
A0032700biological_processnegative regulation of interleukin-17 production
A0032703biological_processnegative regulation of interleukin-2 production
A0032880biological_processregulation of protein localization
A0035584biological_processobsolete calcium-mediated signaling using intracellular calcium source
A0038023molecular_functionsignaling receptor activity
A0042802molecular_functionidentical protein binding
A0043008molecular_functionATP-dependent protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043195cellular_componentterminal bouton
A0043231cellular_componentintracellular membrane-bounded organelle
A0043433biological_processnegative regulation of DNA-binding transcription factor activity
A0043525biological_processpositive regulation of neuron apoptotic process
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045121cellular_componentmembrane raft
A0046007biological_processnegative regulation of activated T cell proliferation
A0046686biological_processresponse to cadmium ion
A0046688biological_processresponse to copper ion
A0046872molecular_functionmetal ion binding
A0050730biological_processregulation of peptidyl-tyrosine phosphorylation
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050860biological_processnegative regulation of T cell receptor signaling pathway
A0051087molecular_functionprotein-folding chaperone binding
A0051260biological_processprotein homooligomerization
A0051726biological_processregulation of cell cycle
A0060090molecular_functionmolecular adaptor activity
A0070062cellular_componentextracellular exosome
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071280biological_processcellular response to copper ion
A0071466biological_processcellular response to xenobiotic stimulus
A0090314biological_processpositive regulation of protein targeting to membrane
A0097062biological_processdendritic spine maintenance
A0098552cellular_componentside of membrane
A0098794cellular_componentpostsynapse
A0140677molecular_functionmolecular function activator activity
A0140693molecular_functionmolecular condensate scaffold activity
A1900272biological_processnegative regulation of long-term synaptic potentiation
A1900449biological_processregulation of glutamate receptor signaling pathway
A1900451biological_processpositive regulation of glutamate receptor signaling pathway
A1901379biological_processregulation of potassium ion transmembrane transport
A1902430biological_processnegative regulation of amyloid-beta formation
A1902951biological_processnegative regulation of dendritic spine maintenance
A1902992biological_processnegative regulation of amyloid precursor protein catabolic process
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1903135molecular_functioncupric ion binding
A1903136molecular_functioncuprous ion binding
A1904645biological_processresponse to amyloid-beta
A1904646biological_processcellular response to amyloid-beta
A1905664biological_processregulation of calcium ion import across plasma membrane
A1990535biological_processneuron projection maintenance
Functional Information from PROSITE/UniProt
site_idPS00291
Number of Residues16
DetailsPRION_1 Prion protein signature 1. AGAAAAGAVVGGLGGY
ChainResidueDetails
AALA113-TYR128

site_idPS00706
Number of Residues19
DetailsPRION_2 Prion protein signature 2. EtDvKMMeRVVeQMCitQY
ChainResidueDetails
AGLU200-TYR218

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:11900542
ChainResidueDetails
AHIS61
AGLY62
AGLY63

site_idSWS_FT_FI2
Number of Residues9
DetailsBINDING: BINDING => ECO:0000305|PubMed:11900542
ChainResidueDetails
AHIS69
AGLY70
AGLY71
AHIS77
AGLY78
AGLY79
AHIS85
AGLY86
AGLY87

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: GPI-anchor amidated serine => ECO:0000250|UniProtKB:P04273
ChainResidueDetails
ASER230

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12214108
ChainResidueDetails
AASN181

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973
ChainResidueDetails
AASN197

218853

PDB entries from 2024-04-24

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