1QK5
TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH XMP, PYROPHOSPHATE AND TWO MG2+ IONS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006178 | biological_process | guanine salvage |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0032265 | biological_process | XMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006178 | biological_process | guanine salvage |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0032265 | biological_process | XMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 302 |
| Chain | Residue |
| A | XMP300 |
| A | POP301 |
| A | HOH2062 |
| A | HOH2065 |
| A | HOH2099 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 303 |
| Chain | Residue |
| A | HOH2102 |
| A | ASP206 |
| A | POP301 |
| A | HOH2083 |
| A | HOH2084 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 302 |
| Chain | Residue |
| B | POP301 |
| B | HOH2049 |
| B | HOH2053 |
| B | HOH2054 |
| B | HOH2077 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 303 |
| Chain | Residue |
| B | ASP206 |
| B | POP301 |
| B | HOH2063 |
| B | HOH2064 |
| B | HOH2078 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE XMP A 300 |
| Chain | Residue |
| A | ASP147 |
| A | ILE148 |
| A | ALA150 |
| A | THR151 |
| A | GLY152 |
| A | PHE153 |
| A | THR154 |
| A | LYS178 |
| A | TRP199 |
| A | ILE200 |
| A | TYR205 |
| A | ASP206 |
| A | POP301 |
| A | MG302 |
| A | HOH2097 |
| A | HOH2098 |
| A | HOH2099 |
| A | HOH2100 |
| A | HOH2102 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE POP A 301 |
| Chain | Residue |
| A | LYS79 |
| A | GLY80 |
| A | ARG114 |
| A | LYS116 |
| A | ASP206 |
| A | ARG212 |
| A | XMP300 |
| A | MG302 |
| A | MG303 |
| A | HOH2062 |
| A | HOH2065 |
| A | HOH2084 |
| A | HOH2086 |
| A | HOH2098 |
| A | HOH2101 |
| A | HOH2102 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE XMP B 300 |
| Chain | Residue |
| B | ASP147 |
| B | ILE148 |
| B | ALA150 |
| B | THR151 |
| B | GLY152 |
| B | PHE153 |
| B | THR154 |
| B | LYS178 |
| B | VAL198 |
| B | TRP199 |
| B | ILE200 |
| B | TYR205 |
| B | ASP206 |
| B | POP301 |
| B | HOH2076 |
| B | HOH2077 |
| B | HOH2078 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE POP B 301 |
| Chain | Residue |
| B | LYS79 |
| B | GLY80 |
| B | ARG114 |
| B | LYS116 |
| B | ASP206 |
| B | ARG212 |
| B | XMP300 |
| B | MG302 |
| B | MG303 |
| B | HOH2049 |
| B | HOH2053 |
| B | HOH2054 |
| B | HOH2063 |
| B | HOH2077 |
| B | HOH2079 |
| B | HOH2080 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIVATGfT |
| Chain | Residue | Details |
| A | VAL142-THR154 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"10545171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11188695","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11188695","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
