1QJI
Structure of astacin with a transition-state analogue inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1201 |
| Chain | Residue |
| A | HIS92 |
| A | HIS96 |
| A | HIS102 |
| A | PKF1202 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PKF A1202 |
| Chain | Residue |
| A | HIS92 |
| A | GLU93 |
| A | HIS96 |
| A | HIS102 |
| A | TYR149 |
| A | SER153 |
| A | ASP175 |
| A | ZN1201 |
| A | HOH2070 |
| A | HOH2085 |
| A | HOH2147 |
| A | HOH2165 |
| A | CYS64 |
| A | TRP65 |
| A | SER66 |
| A | TYR67 |
| A | GLY83 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TIIHELMHAI |
| Chain | Residue | Details |
| A | THR89-ILE98 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 198 |
| Details | Domain: {"description":"Peptidase M12A","evidences":[{"source":"PROSITE-ProRule","id":"PRU01211","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01211","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1319561","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01211","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1319561","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8756323","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ast |
| Chain | Residue | Details |
| A | TYR149 | |
| A | GLU93 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 403 |
| Chain | Residue | Details |
| A | HIS92 | metal ligand |
| A | GLU93 | proton shuttle (general acid/base) |
| A | HIS96 | metal ligand |
| A | HIS102 | metal ligand |
| A | TYR149 | transition state stabiliser |
