Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0031012 | cellular_component | extracellular matrix |
| D | 0004222 | molecular_function | metalloendopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | HIS201 |
| A | HIS205 |
| A | HIS211 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 502 |
| Chain | Residue |
| A | HIS151 |
| A | ASP153 |
| A | HIS166 |
| A | HIS179 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 501 |
| Chain | Residue |
| B | HIS211 |
| B | HIS201 |
| B | HIS205 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 502 |
| Chain | Residue |
| B | HIS151 |
| B | ASP153 |
| B | HIS166 |
| B | HIS179 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN C 501 |
| Chain | Residue |
| C | HIS201 |
| C | HIS205 |
| C | HIS211 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 502 |
| Chain | Residue |
| C | HIS151 |
| C | ASP153 |
| C | HIS166 |
| C | HIS179 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN D 501 |
| Chain | Residue |
| D | HIS201 |
| D | HIS205 |
| D | HIS211 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 502 |
| Chain | Residue |
| D | HIS151 |
| D | ASP153 |
| D | HIS166 |
| D | HIS179 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 503 |
| Chain | Residue |
| A | ASP158 |
| A | GLY159 |
| A | GLY161 |
| A | VAL163 |
| A | ASP181 |
| A | GLU184 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 504 |
| Chain | Residue |
| A | ALA140 |
| A | ASP141 |
| A | GLY173 |
| A | ASN175 |
| A | ASP177 |
| A | HOH301 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 505 |
| Chain | Residue |
| A | ASP107 |
| A | ASP182 |
| A | GLU184 |
| A | HOH302 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 503 |
| Chain | Residue |
| B | ASP158 |
| B | GLY159 |
| B | GLY161 |
| B | VAL163 |
| B | ASP181 |
| B | GLU184 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 504 |
| Chain | Residue |
| B | ALA140 |
| B | ASP141 |
| B | GLY173 |
| B | ASN175 |
| B | ASP177 |
| B | HOH303 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 505 |
| Chain | Residue |
| B | ASP107 |
| B | ASP182 |
| B | GLU184 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 503 |
| Chain | Residue |
| C | ASP158 |
| C | GLY159 |
| C | GLY161 |
| C | VAL163 |
| C | ASP181 |
| C | GLU184 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 504 |
| Chain | Residue |
| C | ALA140 |
| C | ASP141 |
| C | GLY173 |
| C | ASN175 |
| C | ASP177 |
| C | HOH305 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 505 |
| Chain | Residue |
| C | ASP107 |
| C | ASP182 |
| C | GLU184 |
| C | HOH306 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 503 |
| Chain | Residue |
| D | ASP158 |
| D | GLY159 |
| D | GLY161 |
| D | VAL163 |
| D | ASP181 |
| D | GLU184 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 504 |
| Chain | Residue |
| D | ALA140 |
| D | ASP141 |
| D | GLY173 |
| D | ASN175 |
| D | ASP177 |
| D | HOH307 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA D 505 |
| Chain | Residue |
| D | ASP107 |
| D | ASP182 |
| D | GLU184 |
| D | HOH308 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL |
| Chain | Residue | Details |
| A | VAL198-LEU207 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 64 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8740360","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | MET219 | |
| A | GLU202 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | MET219 | |
| B | GLU202 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| C | MET219 | |
| C | GLU202 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| D | MET219 | |
| D | GLU202 | |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU202 | |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | GLU202 | |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| C | GLU202 | |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| D | GLU202 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| A | HIS201 | metal ligand |
| A | GLU202 | proton acceptor, proton donor |
| A | HIS205 | metal ligand |
| A | HIS211 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| B | HIS201 | metal ligand |
| B | GLU202 | proton acceptor, proton donor |
| B | HIS205 | metal ligand |
| B | HIS211 | metal ligand |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| C | HIS201 | metal ligand |
| C | GLU202 | proton acceptor, proton donor |
| C | HIS205 | metal ligand |
| C | HIS211 | metal ligand |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| D | HIS201 | metal ligand |
| D | GLU202 | proton acceptor, proton donor |
| D | HIS205 | metal ligand |
| D | HIS211 | metal ligand |
