1QHM
ESCHERICHIA COLI PYRUVATE FORMATE LYASE LARGE DOMAIN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008861 | molecular_function | formate C-acetyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008861 | molecular_function | formate C-acetyltransferase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: S-acetylcysteine intermediate => ECO:0000269|PubMed:1310545 |
| Chain | Residue | Details |
| A | CYS1418 | |
| B | CYS2418 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Cysteine radical intermediate => ECO:0000269|PubMed:1310545 |
| Chain | Residue | Details |
| A | CYS1419 | |
| B | CYS2419 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:21151122 |
| Chain | Residue | Details |
| A | LYS1062 | |
| A | LYS1116 | |
| A | LYS1194 | |
| A | LYS1453 | |
| B | LYS2062 | |
| B | LYS2116 | |
| B | LYS2194 | |
| B | LYS2453 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000269|PubMed:21151122 |
| Chain | Residue | Details |
| A | LYS1106 | |
| A | LYS1123 | |
| A | LYS1466 | |
| B | LYS2106 | |
| B | LYS2123 | |
| B | LYS2466 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
| Chain | Residue | Details |
| A | LYS1540 | |
| A | LYS1590 | |
| B | LYS2540 | |
| B | LYS2590 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 30 |
| Chain | Residue | Details |
| A | TRP1333 | hydrogen bond donor, radical stabiliser |
| A | CYS1418 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, leaving group (radical), radical combinant |
| A | CYS1419 | hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, hydrogen radical relay |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 30 |
| Chain | Residue | Details |
| B | TRP2333 | hydrogen bond donor, radical stabiliser |
| B | CYS2418 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, leaving group (radical), radical combinant |
| B | CYS2419 | hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, hydrogen radical relay |
