Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004416 | molecular_function | hydroxyacylglutathione hydrolase activity |
| A | 0019243 | biological_process | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
| B | 0004416 | molecular_function | hydroxyacylglutathione hydrolase activity |
| B | 0019243 | biological_process | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 261 |
| Chain | Residue |
| A | HIS54 |
| A | HIS56 |
| A | HIS110 |
| A | ASP134 |
| A | ZN262 |
| A | HOH464 |
| A | HOH465 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 262 |
| Chain | Residue |
| A | ASP58 |
| A | HIS59 |
| A | ASP134 |
| A | HIS173 |
| A | ZN261 |
| A | GSH463 |
| A | HOH464 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 261 |
| Chain | Residue |
| B | HIS54 |
| B | HIS56 |
| B | HIS110 |
| B | ASP134 |
| B | ZN262 |
| B | GBP464 |
| B | HOH466 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 262 |
| Chain | Residue |
| B | ASP58 |
| B | HIS59 |
| B | ASP134 |
| B | HIS173 |
| B | ZN261 |
| B | GBP464 |
| B | HOH466 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GSH A 463 |
| Chain | Residue |
| A | ASP58 |
| A | HIS110 |
| A | ASP134 |
| A | PHE137 |
| A | CYS141 |
| A | GLY142 |
| A | LYS143 |
| A | TYR145 |
| A | HIS173 |
| A | TYR175 |
| A | ARG249 |
| A | LYS252 |
| A | ZN262 |
| A | HOH464 |
| A | HOH465 |
| A | HOH477 |
| A | HOH553 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GBP B 464 |
| Chain | Residue |
| B | HIS56 |
| B | ASP58 |
| B | HIS110 |
| B | ASP134 |
| B | PHE137 |
| B | CYS141 |
| B | GLY142 |
| B | LYS143 |
| B | TYR145 |
| B | HIS173 |
| B | TYR175 |
| B | ARG249 |
| B | LYS252 |
| B | ZN261 |
| B | ZN262 |
| B | HOH466 |
| B | HOH478 |
| B | HOH555 |
| site_id | ZNA |
| Number of Residues | 10 |
| Details | BINUCLEAR ZINC BINDING SITE IN A MOLECULE |
| Chain | Residue |
| A | HIS54 |
| A | HIS173 |
| A | HIS56 |
| A | HIS110 |
| A | ASP134 |
| A | GSH463 |
| A | HOH464 |
| A | HOH465 |
| A | ASP58 |
| A | HIS59 |
| site_id | ZNB |
| Number of Residues | 9 |
| Details | BINUCLEAR ZINC BINDING SITE IN B MOLECULE |
| Chain | Residue |
| B | HIS54 |
| B | HIS56 |
| B | HIS110 |
| B | ASP134 |
| B | GBP464 |
| B | HOH466 |
| B | ASP58 |
| B | HIS59 |
| B | HIS173 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | VAL102 | |
| B | CYS104 | |
| B | ALA106 | |
| B | THR107 | |
| B | GLU158 | |
| B | PHE182 | |
| B | ALA191 | |
| B | TYR221 | |
| A | CYS104 | |
| A | ALA106 | |
| A | THR107 | |
| A | GLU158 | |
| A | PHE182 | |
| A | ALA191 | |
| A | TYR221 | |
| B | VAL102 | |
| Chain | Residue | Details |
| A | CYS116 | |
| B | CYS116 | |
| Chain | Residue | Details |
| A | GLU229 | |
| B | GLU229 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 157 |
| Chain | Residue | Details |
| A | VAL102 | metal ligand |
| A | CYS104 | metal ligand |
| A | ALA106 | activator, electrostatic stabiliser, hydrogen bond acceptor, metal ligand, proton acceptor, proton donor |
| A | THR107 | metal ligand |
| A | GLU158 | metal ligand |
| A | PHE182 | metal ligand |
| A | TYR221 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 157 |
| Chain | Residue | Details |
| B | VAL102 | metal ligand |
| B | CYS104 | metal ligand |
| B | ALA106 | activator, electrostatic stabiliser, hydrogen bond acceptor, metal ligand, proton acceptor, proton donor |
| B | THR107 | metal ligand |
| B | GLU158 | metal ligand |
| B | PHE182 | metal ligand |
| B | TYR221 | metal ligand |
