Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004416 | molecular_function | hydroxyacylglutathione hydrolase activity |
| A | 0019243 | biological_process | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
| B | 0004416 | molecular_function | hydroxyacylglutathione hydrolase activity |
| B | 0019243 | biological_process | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 261 |
| Chain | Residue |
| A | HIS54 |
| A | HIS56 |
| A | HIS110 |
| A | ASP134 |
| A | ZN262 |
| A | CAC463 |
| A | HOH468 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 262 |
| Chain | Residue |
| A | ASP58 |
| A | HIS59 |
| A | ASP134 |
| A | HIS173 |
| A | ZN261 |
| A | CAC463 |
| A | HOH468 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CAC A 463 |
| Chain | Residue |
| A | HIS56 |
| A | ASP58 |
| A | HIS110 |
| A | ASP134 |
| A | TYR145 |
| A | HIS173 |
| A | ZN261 |
| A | ZN262 |
| A | HOH468 |
| A | HOH506 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACT A 464 |
| Chain | Residue |
| A | PHE137 |
| A | CYS141 |
| A | LYS143 |
| A | TYR175 |
| A | ARG249 |
| A | LYS252 |
| A | HOH471 |
| A | HOH507 |
| A | HOH521 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CAC A 265 |
| Chain | Residue |
| A | CYS153 |
| A | GLU158 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 266 |
| Chain | Residue |
| A | HIS185 |
| A | HIS235 |
| A | GLU251 |
| A | CL467 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 467 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 261 |
| Chain | Residue |
| B | HIS54 |
| B | HIS56 |
| B | HIS110 |
| B | ASP134 |
| B | ZN262 |
| B | CAC469 |
| B | HOH473 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 262 |
| Chain | Residue |
| B | ASP58 |
| B | HIS59 |
| B | ASP134 |
| B | HIS173 |
| B | ZN261 |
| B | CAC469 |
| B | HOH473 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CAC B 469 |
| Chain | Residue |
| B | HIS56 |
| B | ASP58 |
| B | HIS110 |
| B | ASP134 |
| B | HIS173 |
| B | TYR175 |
| B | ZN261 |
| B | ZN262 |
| B | HOH473 |
| B | HOH511 |
| B | HOH616 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 468 |
| Chain | Residue |
| B | PHE137 |
| B | CYS141 |
| B | TYR175 |
| B | ARG249 |
| B | LYS252 |
| B | HOH476 |
| B | HOH512 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CAC B 265 |
| Chain | Residue |
| B | CYS153 |
| B | LYS154 |
| B | GLU158 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 266 |
| Chain | Residue |
| B | HOH659 |
| A | CL467 |
| B | HIS185 |
| B | GLU251 |
| B | HOH527 |
| B | HOH554 |
| site_id | ZNA |
| Number of Residues | 9 |
| Details | BINUCLEAR ZINC BINDING SITE IN A MOLECULE |
| Chain | Residue |
| A | HIS54 |
| A | HIS56 |
| A | HIS110 |
| A | ASP134 |
| A | CAC463 |
| A | HOH468 |
| A | ASP58 |
| A | HIS59 |
| A | HIS173 |
| site_id | ZNB |
| Number of Residues | 9 |
| Details | BINUCLEAR ZINC BINDING SITE IN B MOLECULE |
| Chain | Residue |
| B | HIS54 |
| B | HIS56 |
| B | HIS110 |
| B | ASP134 |
| B | CAC469 |
| B | HOH473 |
| B | ASP58 |
| B | HIS59 |
| B | HIS173 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10508780","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99KB8","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q99KB8","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qh5 |
| Chain | Residue | Details |
| A | ASP58 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qh5 |
| Chain | Residue | Details |
| B | ASP58 | |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 157 |
| Chain | Residue | Details |
| A | HIS54 | metal ligand |
| A | HIS56 | metal ligand |
| A | ASP58 | activator, electrostatic stabiliser, hydrogen bond acceptor, metal ligand, proton acceptor, proton donor |
| A | HIS59 | metal ligand |
| A | HIS110 | metal ligand |
| A | ASP134 | metal ligand |
| A | HIS173 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 157 |
| Chain | Residue | Details |
| B | HIS54 | metal ligand |
| B | HIS56 | metal ligand |
| B | ASP58 | activator, electrostatic stabiliser, hydrogen bond acceptor, metal ligand, proton acceptor, proton donor |
| B | HIS59 | metal ligand |
| B | HIS110 | metal ligand |
| B | ASP134 | metal ligand |
| B | HIS173 | metal ligand |
