1QF9

PH INFLUENCES FLUORIDE COORDINATION NUMBER OF THE ALFX PHOSPHORYL TRANSFER TRANSITION STATE ANALOG IN UMP/CMP KINASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004017	molecular_function	adenylate kinase activity
A	0004127	molecular_function	cytidylate kinase activity
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006225	biological_process	UDP biosynthetic process
A	0009041	molecular_function	UMP/dUMP kinase activity
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0016776	molecular_function	phosphotransferase activity, phosphate group as acceptor
A	0019205	molecular_function	nucleobase-containing compound kinase activity
A	0033862	molecular_function	UMP kinase activity
A	0036430	molecular_function	CMP kinase activity
A	0036431	molecular_function	dCMP kinase activity
A	0043100	biological_process	pyrimidine nucleobase salvage
A	0043173	biological_process	nucleotide salvage
A	0046705	biological_process	CDP biosynthetic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
A	0072528	biological_process	pyrimidine-containing compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ALF A 499

Chain	Residue
A	PRO15
A	HOH198
A	MG500
A	GLY16
A	LYS19
A	ARG93
A	ARG131
A	ARG137
A	ARG148
A	ADP195
A	C5P196

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 500

Chain	Residue
A	ADP195
A	HOH198
A	HOH215
A	HOH220
A	HOH227
A	ALF499

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site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP A 195

Chain	Residue
A	GLY16
A	SER17
A	GLY18
A	LYS19
A	GLY20
A	THR21
A	ARG127
A	ARG131
A	ARG176
A	VAL178
A	HOH216
A	HOH220
A	HOH232
A	HOH239
A	ALF499
A	MG500
A	HOH606
A	HOH778
A	HOH891

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site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE C5P A 196

Chain	Residue
A	GLY38
A	LEU41
A	ARG42
A	ILE59
A	GLU63
A	ILE64
A	VAL65
A	GLY90
A	PHE91
A	ARG93
A	ASN97
A	ARG137
A	ASP139
A	ARG148
A	HOH198
A	HOH200
A	HOH208
A	HOH212
A	HOH215
A	ALF499
A	HOH727

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Functional Information from PROSITE/UniProt

site_id	PS00113
Number of Residues	12
Details	ADENYLATE_KINASE Adenylate kinase signature. FLVDGFPRneeN

Chain	Residue	Details
A	PHE86-ASN97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10426946, ECO:0000269|PubMed:8703943, ECO:0000269|PubMed:9280438

Chain	Residue	Details
A	SER17
A	GLN43
A	ILE64
A	PHE91
A	GLY132
A	PHE149
A	ASP177

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10426946, ECO:0000269|PubMed:9280438

Chain	Residue	Details
A	ASN98
A	SER138

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