1QAM

THE STRUCTURE OF THE RRNA METHYLTRANSFERASE ERMC': IMPLICATIONS FOR THE REACTION MECHANISM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000154	biological_process	rRNA modification
A	0000179	molecular_function	rRNA (adenine-N6,N6-)-dimethyltransferase activity
A	0003723	molecular_function	RNA binding
A	0005829	cellular_component	cytosol
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0031167	biological_process	rRNA methylation
A	0032259	biological_process	methylation
A	0046677	biological_process	response to antibiotic
A	0052910	molecular_function	23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 901

Chain	Residue
A	PHE131
A	ARG134
A	ARG140
A	HOH943

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT A 902

Chain	Residue
A	GLN79
A	HOH907
A	HOH1019
A	HOH1092
A	SER15
A	LYS16
A	HIS17
A	ASN33
A	PHE54

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Functional Information from PROSITE/UniProt

site_id	PS01131
Number of Residues	28
Details	RRNA_A_DIMETH Ribosomal RNA adenine dimethylases signature. IFEiGSGkGhFTlelVqrcnf...VtAIEiD

Chain	Residue	Details
A	ILE34-ASP61

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	a catalytic site defined by CSA, PubMed 9585521, 10366505

Chain	Residue	Details
A	GLY38
A	ASN101
A	GLU59

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site_id	MCSA1
Number of Residues	5
Details	M-CSA 898

Chain	Residue	Details
A	GLY38	activator, electrostatic stabiliser
A	GLU59	activator, electrostatic stabiliser
A	ASN101	activator, electrostatic stabiliser
A	TYR104	activator, electrostatic stabiliser
A	PHE163	activator, electrostatic stabiliser

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