1Q7B
The structure of betaketoacyl-[ACP] reductase from E. coli in complex with NADP+
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
A | 0005829 | cellular_component | cytosol |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0006633 | biological_process | fatty acid biosynthetic process |
A | 0008610 | biological_process | lipid biosynthetic process |
A | 0009102 | biological_process | biotin biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0030497 | biological_process | fatty acid elongation |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
B | 0005829 | cellular_component | cytosol |
B | 0006629 | biological_process | lipid metabolic process |
B | 0006631 | biological_process | fatty acid metabolic process |
B | 0006633 | biological_process | fatty acid biosynthetic process |
B | 0008610 | biological_process | lipid biosynthetic process |
B | 0009102 | biological_process | biotin biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0030497 | biological_process | fatty acid elongation |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
C | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
C | 0005829 | cellular_component | cytosol |
C | 0006629 | biological_process | lipid metabolic process |
C | 0006631 | biological_process | fatty acid metabolic process |
C | 0006633 | biological_process | fatty acid biosynthetic process |
C | 0008610 | biological_process | lipid biosynthetic process |
C | 0009102 | biological_process | biotin biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0030497 | biological_process | fatty acid elongation |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0050661 | molecular_function | NADP binding |
C | 0051287 | molecular_function | NAD binding |
D | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
D | 0005829 | cellular_component | cytosol |
D | 0006629 | biological_process | lipid metabolic process |
D | 0006631 | biological_process | fatty acid metabolic process |
D | 0006633 | biological_process | fatty acid biosynthetic process |
D | 0008610 | biological_process | lipid biosynthetic process |
D | 0009102 | biological_process | biotin biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0030497 | biological_process | fatty acid elongation |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0050661 | molecular_function | NADP binding |
D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 9001 |
Chain | Residue |
B | GLU233 |
B | THR234 |
B | HOH3037 |
C | GLU233 |
C | THR234 |
C | HOH2037 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 9002 |
Chain | Residue |
D | GLU233 |
D | THR234 |
D | HOH1037 |
A | GLU233 |
A | THR234 |
A | HOH4037 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA B 9003 |
Chain | Residue |
B | GLY50 |
B | GLY53 |
B | HOH2063 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA C 9004 |
Chain | Residue |
C | ASN145 |
C | HOH3046 |
C | HOH3204 |
C | HOH4041 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA D 9005 |
Chain | Residue |
D | ASN145 |
D | HOH3041 |
D | HOH4046 |
D | HOH4056 |
D | HOH4213 |
D | HOH4214 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA A 9007 |
Chain | Residue |
A | ASN145 |
A | HOH1046 |
A | HOH1056 |
A | HOH1159 |
A | HOH2041 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA B 9008 |
Chain | Residue |
B | ASN145 |
B | HOH1041 |
B | HOH2046 |
site_id | AC8 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NAP A 1901 |
Chain | Residue |
A | GLY12 |
A | SER14 |
A | ARG15 |
A | ILE17 |
A | THR37 |
A | LEU58 |
A | ASN59 |
A | VAL60 |
A | ASN86 |
A | ALA87 |
A | GLY88 |
A | ILE89 |
A | ILE136 |
A | GLY137 |
A | SER138 |
A | TYR151 |
A | LYS155 |
A | PRO181 |
A | GLY182 |
A | ILE184 |
A | THR186 |
A | HOH1038 |
A | HOH1045 |
A | HOH1053 |
A | HOH1066 |
A | HOH1133 |
site_id | AC9 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE NAP B 2901 |
Chain | Residue |
B | GLY12 |
B | SER14 |
B | ARG15 |
B | ILE17 |
B | ALA36 |
B | THR37 |
B | LEU58 |
B | ASN59 |
B | VAL60 |
B | ASN86 |
B | ALA87 |
B | GLY88 |
B | ILE136 |
B | GLY137 |
B | SER138 |
B | TYR151 |
B | LYS155 |
B | PRO181 |
B | GLY182 |
B | ILE184 |
B | THR186 |
B | HOH2038 |
B | HOH2045 |
B | HOH2053 |
B | HOH2066 |
site_id | BC1 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NAP C 3901 |
Chain | Residue |
C | LYS155 |
C | PRO181 |
C | GLY182 |
C | ILE184 |
C | THR186 |
C | HOH3038 |
C | HOH3045 |
C | HOH3053 |
C | HOH3066 |
C | HOH3112 |
C | HOH3113 |
C | HOH3187 |
C | HOH3191 |
C | GLY12 |
C | SER14 |
C | ARG15 |
C | ILE17 |
C | THR37 |
C | LEU58 |
C | ASN59 |
C | VAL60 |
C | ASN86 |
C | ALA87 |
C | GLY88 |
C | ILE89 |
C | ILE136 |
C | GLY137 |
C | TYR151 |
site_id | BC2 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NAP D 4901 |
Chain | Residue |
D | GLY12 |
D | SER14 |
D | ARG15 |
D | ALA36 |
D | THR37 |
D | LEU58 |
D | ASN59 |
D | VAL60 |
D | ASN86 |
D | ALA87 |
D | GLY88 |
D | ILE89 |
D | ILE136 |
D | GLY137 |
D | SER138 |
D | TYR151 |
D | LYS155 |
D | PRO181 |
D | GLY182 |
D | ILE184 |
D | THR186 |
D | HOH4038 |
D | HOH4045 |
D | HOH4053 |
D | HOH4112 |
D | HOH4113 |
D | HOH4234 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgtmgnggQanYAAAKAGLiGFSkSLA |
Chain | Residue | Details |
A | SER138-ALA166 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 |
Chain | Residue | Details |
A | TYR151 | |
B | TYR151 | |
C | TYR151 | |
D | TYR151 |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B, ECO:0007744|PDB:1Q7C |
Chain | Residue | Details |
A | GLY12 | |
C | THR37 | |
C | ASN59 | |
C | TYR151 | |
D | GLY12 | |
D | THR37 | |
D | ASN59 | |
D | TYR151 | |
A | THR37 | |
A | ASN59 | |
A | TYR151 | |
B | GLY12 | |
B | THR37 | |
B | ASN59 | |
B | TYR151 | |
C | GLY12 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: |
Chain | Residue | Details |
A | GLY50 | |
B | THR234 | |
C | GLY50 | |
C | GLY53 | |
C | ASN145 | |
C | GLU233 | |
C | THR234 | |
D | GLY50 | |
D | GLY53 | |
D | ASN145 | |
D | GLU233 | |
A | GLY53 | |
D | THR234 | |
A | ASN145 | |
A | GLU233 | |
A | THR234 | |
B | GLY50 | |
B | GLY53 | |
B | ASN145 | |
B | GLU233 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15016358, ECO:0007744|PDB:1Q7B |
Chain | Residue | Details |
A | ASN86 | |
B | ASN86 | |
C | ASN86 | |
D | ASN86 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | SER138 | |
B | SER138 | |
C | SER138 | |
D | SER138 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15016358 |
Chain | Residue | Details |
A | ILE184 | |
B | ILE184 | |
C | ILE184 | |
D | ILE184 |