1Q6X

Crystal structure of rat choline acetyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001547	biological_process	antral ovarian follicle growth
A	0001666	biological_process	response to hypoxia
A	0004102	molecular_function	choline O-acetyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0007274	biological_process	neuromuscular synaptic transmission
A	0007584	biological_process	response to nutrient
A	0007613	biological_process	memory
A	0008292	biological_process	acetylcholine biosynthetic process
A	0009410	biological_process	response to xenobiotic stimulus
A	0016746	molecular_function	acyltransferase activity
A	0033265	molecular_function	choline binding
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0045471	biological_process	response to ethanol
B	0001547	biological_process	antral ovarian follicle growth
B	0001666	biological_process	response to hypoxia
B	0004102	molecular_function	choline O-acetyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0007274	biological_process	neuromuscular synaptic transmission
B	0007584	biological_process	response to nutrient
B	0007613	biological_process	memory
B	0008292	biological_process	acetylcholine biosynthetic process
B	0009410	biological_process	response to xenobiotic stimulus
B	0016746	molecular_function	acyltransferase activity
B	0033265	molecular_function	choline binding
B	0043005	cellular_component	neuron projection
B	0045202	cellular_component	synapse
B	0045471	biological_process	response to ethanol

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 1001

Chain	Residue
B	PHE588
B	HIS589
B	CYS591
B	THR594
B	HOH1018
B	HOH1045

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 1002

Chain	Residue
A	THR594
A	HOH1047
A	HOH1096
A	PHE588
A	HIS589
A	CYS591

---

Functional Information from PROSITE/UniProt

site_id	PS00439
Number of Residues	16
Details	ACYLTRANSF_C_1 Acyltransferases ChoActase / COT / CPT family signature 1. LPkLPVPpLqQTLatY

Chain	Residue	Details
A	LEU23-TYR38

---

site_id	PS00440
Number of Residues	28
Details	ACYLTRANSF_C_2 Acyltransferases ChoActase / COT / CPT family signature 2. RWyDKsLqFVvgrDGtcgvvcEHspfDG

Chain	Residue	Details
A	ARG312-GLY339

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 15131697, 12526798, 12562770

Chain	Residue	Details
A	HIS334
A	SER550
A	TYR95
A	PRO108

---

site_id	CSA2
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 15131697, 12526798, 12562770

Chain	Residue	Details
B	HIS334
B	SER550
B	TYR95
B	PRO108

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 605

Chain	Residue	Details
A	TYR95
A	PRO108
A	HIS334
A	SER550

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 605

Chain	Residue	Details
B	TYR95
B	PRO108
B	HIS334
B	SER550

---