Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
A | 0006470 | biological_process | protein dephosphorylation |
A | 0016311 | biological_process | dephosphorylation |
B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
B | 0006470 | biological_process | protein dephosphorylation |
B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 5000 |
Chain | Residue |
A | HIS554 |
A | HOH4001 |
A | HOH4002 |
A | HOH4006 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 5010 |
Chain | Residue |
A | HOH2172 |
A | HOH4012 |
A | HOH4013 |
A | HOH4015 |
A | HOH4016 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG B 5020 |
Chain | Residue |
B | HIS1054 |
B | GLU1130 |
B | HOH4021 |
B | HOH4022 |
B | HOH4023 |
B | HOH4024 |
B | HOH4026 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 5030 |
Chain | Residue |
A | HOH4035 |
B | GLU1026 |
B | HOH4032 |
B | HOH4033 |
B | HOH4036 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 6001 |
Chain | Residue |
A | ARG524 |
A | ARG754 |
A | GLN762 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B 6002 |
Chain | Residue |
B | ARG1024 |
B | ARG1254 |
B | GLN1262 |
site_id | AC7 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE P90 A 801 |
Chain | Residue |
A | TYR546 |
A | ARG547 |
A | ASP548 |
A | SER618 |
A | PHE682 |
A | CYS715 |
A | SER716 |
A | ALA717 |
A | GLY718 |
A | ILE719 |
A | GLY720 |
A | ARG721 |
A | GLN762 |
A | HOH2001 |
A | HOH2103 |
B | ALA1018 |
B | ASP1022 |
B | HIS1025 |
B | GLU1026 |
site_id | AC8 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE P90 B 1301 |
Chain | Residue |
A | GLY514 |
A | ALA518 |
A | GLN521 |
B | TYR1046 |
B | ARG1047 |
B | ASP1048 |
B | LYS1120 |
B | PHE1182 |
B | CYS1215 |
B | SER1216 |
B | ALA1217 |
B | GLY1218 |
B | ILE1219 |
B | GLY1220 |
B | ARG1221 |
B | GLN1262 |
B | HOH2002 |
B | HOH2099 |
Functional Information from PROSITE/UniProt
site_id | PS00383 |
Number of Residues | 11 |
Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRSG |
Chain | Residue | Details |
A | VAL713-GLY723 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Phosphocysteine intermediate |
Chain | Residue | Details |
A | CYS715 | |
B | CYS1215 | |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP681 | |
B | ASP1181 | |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | CYS715 | |
A | GLN762 | |
B | CYS1215 | |
B | GLN1262 | |
Chain | Residue | Details |
A | MET501 | |
B | MET1001 | |
Chain | Residue | Details |
A | TYR520 | |
B | TYR1020 | |
Chain | Residue | Details |
A | SER550 | |
B | SER1050 | |
Chain | Residue | Details |
A | TYR566 | |
B | TYR1066 | |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: S-nitrosocysteine; in reversibly inhibited form => ECO:0000269|PubMed:22169477 |
Chain | Residue | Details |
A | CYS715 | |
B | CYS1215 | |
Chain | Residue | Details |
A | SER742 | |
A | SER743 | |
B | SER1242 | |
B | SER1243 | |
Chain | Residue | Details |
A | CYS715 | |
A | SER716 | |
B | CYS1215 | |
B | SER1216 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1d5r |
Chain | Residue | Details |
A | ARG721 | |
A | CYS715 | |
A | ASP681 | |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1d5r |
Chain | Residue | Details |
B | ASP1181 | |
B | ARG1221 | |
B | CYS1215 | |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1d5r |
Chain | Residue | Details |
A | ARG721 | |
A | SER722 | |
A | CYS715 | |
A | ASP681 | |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1d5r |
Chain | Residue | Details |
B | ASP1181 | |
B | SER1222 | |
B | ARG1221 | |
B | CYS1215 | |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 469 |
Chain | Residue | Details |
A | ASP681 | proton shuttle (general acid/base) |
A | CYS715 | covalent catalysis |
A | ARG721 | activator, electrostatic stabiliser |
A | SER722 | activator, electrostatic stabiliser |
A | GLN762 | steric role |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 469 |
Chain | Residue | Details |
B | ASP1181 | proton shuttle (general acid/base) |
B | CYS1215 | covalent catalysis |
B | ARG1221 | activator, electrostatic stabiliser |
B | SER1222 | activator, electrostatic stabiliser |
B | GLN1262 | steric role |