1Q6L
Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019854 | biological_process | L-ascorbic acid catabolic process |
| A | 0033982 | molecular_function | 3-dehydro-L-gulonate-6-phosphate decarboxylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019854 | biological_process | L-ascorbic acid catabolic process |
| B | 0033982 | molecular_function | 3-dehydro-L-gulonate-6-phosphate decarboxylase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 5300 |
| Chain | Residue |
| A | GLU33 |
| A | ASP62 |
| A | TX45301 |
| A | HOH5372 |
| A | HOH5373 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 9300 |
| Chain | Residue |
| B | HOH9408 |
| B | GLU33 |
| B | ASP62 |
| B | TX49301 |
| B | HOH9407 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE TX4 A 5301 |
| Chain | Residue |
| A | ALA9 |
| A | ASP11 |
| A | GLU33 |
| A | ASP62 |
| A | LYS64 |
| A | HIS136 |
| A | THR169 |
| A | GLY171 |
| A | GLY191 |
| A | ARG192 |
| A | MG5300 |
| A | HOH5303 |
| A | HOH5308 |
| A | HOH5312 |
| A | HOH5326 |
| A | HOH5372 |
| A | HOH5373 |
| A | HOH5376 |
| A | HOH5398 |
| B | ASP67 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE TX4 B 9301 |
| Chain | Residue |
| A | ASP67 |
| B | ALA9 |
| B | ASP11 |
| B | GLU33 |
| B | ASP62 |
| B | LYS64 |
| B | HIS136 |
| B | THR169 |
| B | GLY171 |
| B | GLY191 |
| B | ARG192 |
| B | MG9300 |
| B | HOH9303 |
| B | HOH9314 |
| B | HOH9316 |
| B | HOH9407 |
| B | HOH9408 |
| B | HOH9409 |
| B | HOH9411 |
| B | HOH9413 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP11 | |
| A | GLU33 | |
| A | ASP62 | |
| A | ARG192 | |
| B | ASP11 | |
| B | GLU33 | |
| B | ASP62 | |
| B | ARG192 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Transition state stabilizer |
| Chain | Residue | Details |
| A | LYS64 | |
| A | ASP67 | |
| B | LYS64 | |
| B | ASP67 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 9 |
| Details |
| Chain | Residue | Details |
| A | HIS136 | |
| A | LYS64 | |
| A | GLU112 | |
| A | ARG139 | |
| A | ILE37 | |
| A | THR36 | |
| B | ALA68 | |
| B | LEU72 | |
| B | ASP67 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details |
| Chain | Residue | Details |
| B | HIS136 | |
| B | LYS64 | |
| B | ARG139 | |
| B | GLU112 | |
| B | ILE37 | |
| B | THR36 |
| site_id | CSA3 |
| Number of Residues | 9 |
| Details |
| Chain | Residue | Details |
| A | HIS136 | |
| A | LYS64 | |
| A | GLU112 | |
| A | ARG139 | |
| A | ILE37 | |
| A | THR36 | |
| B | ALA68 | |
| B | LEU72 | |
| B | ASP67 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details |
| Chain | Residue | Details |
| A | ALA68 | |
| A | LEU72 | |
| A | ASP67 |
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 236 |
| Chain | Residue | Details |
| A | THR36 | ground state destabiliser |
| A | ILE37 | ground state destabiliser |
| A | LYS64 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor |
| A | ASP67 | electrostatic stabiliser, hydrogen bond acceptor |
| A | ALA68 | ground state destabiliser |
| A | LEU72 | ground state destabiliser |
| A | GLU112 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity |
| A | HIS136 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ARG139 | hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 236 |
| Chain | Residue | Details |
| B | THR36 | ground state destabiliser |
| B | ILE37 | ground state destabiliser |
| B | LYS64 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor |
| B | ASP67 | electrostatic stabiliser, hydrogen bond acceptor |
| B | ALA68 | ground state destabiliser |
| B | LEU72 | ground state destabiliser |
| B | GLU112 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity |
| B | HIS136 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ARG139 | hydrogen bond donor, proton acceptor, proton donor |
