1Q52
Crystal Structure of Mycobacterium tuberculosis MenB, a Key Enzyme in Vitamin K2 Biosynthesis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0034214 | biological_process | protein hexamerization |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0034214 | biological_process | protein hexamerization |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0034214 | biological_process | protein hexamerization |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0034214 | biological_process | protein hexamerization |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| E | 0009234 | biological_process | menaquinone biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0034214 | biological_process | protein hexamerization |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| F | 0009234 | biological_process | menaquinone biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0034214 | biological_process | protein hexamerization |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| G | 0009234 | biological_process | menaquinone biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0034214 | biological_process | protein hexamerization |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| H | 0009234 | biological_process | menaquinone biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0034214 | biological_process | protein hexamerization |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| I | 0009234 | biological_process | menaquinone biosynthetic process |
| I | 0016829 | molecular_function | lyase activity |
| I | 0034214 | biological_process | protein hexamerization |
| J | 0005886 | cellular_component | plasma membrane |
| J | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| J | 0009234 | biological_process | menaquinone biosynthetic process |
| J | 0016829 | molecular_function | lyase activity |
| J | 0034214 | biological_process | protein hexamerization |
| K | 0005886 | cellular_component | plasma membrane |
| K | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| K | 0009234 | biological_process | menaquinone biosynthetic process |
| K | 0016829 | molecular_function | lyase activity |
| K | 0034214 | biological_process | protein hexamerization |
| L | 0005886 | cellular_component | plasma membrane |
| L | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| L | 0009234 | biological_process | menaquinone biosynthetic process |
| L | 0016829 | molecular_function | lyase activity |
| L | 0034214 | biological_process | protein hexamerization |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_01934","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12909628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21830810","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_01934","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12909628","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_01934","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21830810","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0ABU0","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_01934","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Site: {"description":"Important for catalysis","evidences":[{"source":"HAMAP-Rule","id":"MF_01934","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20643650","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21830810","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Site: {"description":"Important for catalysis","evidences":[{"source":"UniProtKB","id":"P0ABU0","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_01934","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12909628","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"12909628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21830810","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| A | ASP192 | |
| A | ASP185 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| J | ASP192 | |
| J | ASP185 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| K | ASP192 | |
| K | ASP185 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| L | ASP192 | |
| L | ASP185 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| B | ASP192 | |
| B | ASP185 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| C | ASP192 | |
| C | ASP185 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| D | ASP192 | |
| D | ASP185 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| E | ASP192 | |
| E | ASP185 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| F | ASP192 | |
| F | ASP185 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| G | ASP192 | |
| G | ASP185 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| H | ASP192 | |
| H | ASP185 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dci |
| Chain | Residue | Details |
| I | ASP192 | |
| I | ASP185 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| A | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| A | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP185 | activator |
| A | SER190 | activator |
| A | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA10 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| J | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| J | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| J | ASP185 | activator |
| J | SER190 | activator |
| J | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA11 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| K | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| K | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| K | ASP185 | activator |
| K | SER190 | activator |
| K | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA12 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| L | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| L | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| L | ASP185 | activator |
| L | SER190 | activator |
| L | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| B | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| B | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP185 | activator |
| B | SER190 | activator |
| B | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| C | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| C | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| C | ASP185 | activator |
| C | SER190 | activator |
| C | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| D | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| D | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| D | ASP185 | activator |
| D | SER190 | activator |
| D | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA5 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| E | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| E | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| E | ASP185 | activator |
| E | SER190 | activator |
| E | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA6 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| F | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| F | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| F | ASP185 | activator |
| F | SER190 | activator |
| F | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA7 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| G | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| G | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| G | ASP185 | activator |
| G | SER190 | activator |
| G | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA8 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| H | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| H | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| H | ASP185 | activator |
| H | SER190 | activator |
| H | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
| site_id | MCSA9 |
| Number of Residues | 5 |
| Details | M-CSA 346 |
| Chain | Residue | Details |
| I | GLY105 | electrostatic stabiliser, hydrogen bond donor |
| I | GLY161 | electrostatic stabiliser, hydrogen bond donor |
| I | ASP185 | activator |
| I | SER190 | activator |
| I | TYR287 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, polar interaction, proton acceptor, proton donor, steric role |
