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1Q2U

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

Replaces:  1PS4
Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0001046molecular_functioncore promoter sequence-specific DNA binding
A0001933biological_processnegative regulation of protein phosphorylation
A0001963biological_processsynaptic transmission, dopaminergic
A0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
A0003690molecular_functiondouble-stranded DNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0003713molecular_functiontranscription coactivator activity
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005102molecular_functionsignaling receptor binding
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0005759cellular_componentmitochondrial matrix
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0006281biological_processDNA repair
A0006508biological_processproteolysis
A0006914biological_processautophagy
A0006954biological_processinflammatory response
A0006979biological_processresponse to oxidative stress
A0007005biological_processmitochondrion organization
A0007265biological_processRas protein signal transduction
A0007338biological_processsingle fertilization
A0008021cellular_componentsynaptic vesicle
A0008047molecular_functionenzyme activator activity
A0008233molecular_functionpeptidase activity
A0008344biological_processadult locomotory behavior
A0009438biological_processmethylglyoxal metabolic process
A0010273biological_processdetoxification of copper ion
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0016532molecular_functionsuperoxide dismutase copper chaperone activity
A0016605cellular_componentPML body
A0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
A0019249biological_processlactate biosynthetic process
A0019430biological_processremoval of superoxide radicals
A0019826molecular_functionoxygen sensor activity
A0019899molecular_functionenzyme binding
A0019900molecular_functionkinase binding
A0019955molecular_functioncytokine binding
A0030073biological_processinsulin secretion
A0030091biological_processprotein repair
A0030414molecular_functionpeptidase inhibitor activity
A0030424cellular_componentaxon
A0030521biological_processandrogen receptor signaling pathway
A0030546molecular_functionsignaling receptor activator activity
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031397biological_processnegative regulation of protein ubiquitination
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032679biological_processregulation of TRAIL production
A0032757biological_processpositive regulation of interleukin-8 production
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0033234biological_processnegative regulation of protein sumoylation
A0034599biological_processcellular response to oxidative stress
A0034614biological_processcellular response to reactive oxygen species
A0036470molecular_functiontyrosine 3-monooxygenase activator activity
A0036471biological_processcellular response to glyoxal
A0036478molecular_functionL-dopa decarboxylase activator activity
A0036524molecular_functionprotein deglycase activity
A0042177biological_processnegative regulation of protein catabolic process
A0042542biological_processresponse to hydrogen peroxide
A0042593biological_processglucose homeostasis
A0042743biological_processhydrogen peroxide metabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043523biological_processregulation of neuron apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0044297cellular_componentcell body
A0044388molecular_functionsmall protein activating enzyme binding
A0044390molecular_functionubiquitin-like protein conjugating enzyme binding
A0045121cellular_componentmembrane raft
A0045296molecular_functioncadherin binding
A0045340molecular_functionmercury ion binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046295biological_processglycolate biosynthetic process
A0046826biological_processnegative regulation of protein export from nucleus
A0048471cellular_componentperinuclear region of cytoplasm
A0050681molecular_functionnuclear androgen receptor binding
A0050727biological_processregulation of inflammatory response
A0050787biological_processdetoxification of mercury ion
A0050821biological_processprotein stabilization
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051881biological_processregulation of mitochondrial membrane potential
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051899biological_processmembrane depolarization
A0051920molecular_functionperoxiredoxin activity
A0055105molecular_functionubiquitin-protein transferase inhibitor activity
A0060081biological_processmembrane hyperpolarization
A0060765biological_processregulation of androgen receptor signaling pathway
A0061691biological_processdetoxification of hydrogen peroxide
A0061727biological_processmethylglyoxal catabolic process to lactate
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0070994biological_processdetection of oxidative stress
A0097110molecular_functionscaffold protein binding
A0106044biological_processguanine deglycation
A0106045biological_processguanine deglycation, methylglyoxal removal
A0106046biological_processguanine deglycation, glyoxal removal
A0110095biological_processcellular detoxification of aldehyde
A0140041biological_processcellular detoxification of methylglyoxal
A0140297molecular_functionDNA-binding transcription factor binding
A1900182biological_processpositive regulation of protein localization to nucleus
A1900242biological_processregulation of synaptic vesicle endocytosis
A1901984biological_processnegative regulation of protein acetylation
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1902903biological_processregulation of supramolecular fiber organization
A1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
A1903073biological_processnegative regulation of death-inducing signaling complex assembly
A1903094biological_processnegative regulation of protein K48-linked deubiquitination
A1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
A1903135molecular_functioncupric ion binding
A1903136molecular_functioncuprous ion binding
A1903181biological_processpositive regulation of dopamine biosynthetic process
A1903189biological_processglyoxal metabolic process
A1903190biological_processglyoxal catabolic process
A1903197biological_processpositive regulation of L-dopa biosynthetic process
A1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
A1903599biological_processpositive regulation of autophagy of mitochondrion
A1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
A1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
A1990381molecular_functionubiquitin-specific protease binding
A1990422molecular_functionglyoxalase (glycolic acid-forming) activity
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Nucleophile => ECO:0000305|PubMed:20304780, ECO:0000305|PubMed:25416785
ChainResidueDetails
ACYS106

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:20304780
ChainResidueDetails
AHIS126

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Cleavage; by CASP6 => ECO:0000250|UniProtKB:Q99LX0
ChainResidueDetails
AASP149

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:25944712
ChainResidueDetails
AALA2

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR67

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Cysteine sulfinic acid (-SO2H); alternate => ECO:0000269|PubMed:12939276
ChainResidueDetails
ACYS106

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99LX0
ChainResidueDetails
ALYS148

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q99LX0
ChainResidueDetails
ALYS182

site_idSWS_FT_FI9
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:23847046
ChainResidueDetails
ACYS46
ACYS53

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine; alternate => ECO:0000269|PubMed:23847046
ChainResidueDetails
ACYS106

site_idSWS_FT_FI11
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:15976810
ChainResidueDetails
ALYS130

227344

PDB entries from 2024-11-13

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