1Q23
Crystal structure of Chloramphenicol acetyltransferase I complexed with Fusidic acid at 2.18 A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0046677 | biological_process | response to antibiotic |
B | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0046677 | biological_process | response to antibiotic |
C | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0046677 | biological_process | response to antibiotic |
D | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0046677 | biological_process | response to antibiotic |
E | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
E | 0016746 | molecular_function | acyltransferase activity |
E | 0046677 | biological_process | response to antibiotic |
F | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
F | 0016746 | molecular_function | acyltransferase activity |
F | 0046677 | biological_process | response to antibiotic |
G | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
G | 0016746 | molecular_function | acyltransferase activity |
G | 0046677 | biological_process | response to antibiotic |
H | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
H | 0016746 | molecular_function | acyltransferase activity |
H | 0046677 | biological_process | response to antibiotic |
I | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
I | 0016746 | molecular_function | acyltransferase activity |
I | 0046677 | biological_process | response to antibiotic |
J | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
J | 0016746 | molecular_function | acyltransferase activity |
J | 0046677 | biological_process | response to antibiotic |
K | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
K | 0016746 | molecular_function | acyltransferase activity |
K | 0046677 | biological_process | response to antibiotic |
L | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
L | 0016746 | molecular_function | acyltransferase activity |
L | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CA A 801 |
Chain | Residue |
A | ASN68 |
A | HOH817 |
A | HOH840 |
A | HOH858 |
H | ASN68 |
H | HOH732 |
H | HOH737 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE FUA C 701 |
Chain | Residue |
A | HIS193 |
C | THR93 |
C | PHE102 |
C | SER104 |
C | TYR133 |
C | PHE134 |
C | PHE144 |
C | SER146 |
C | PHE156 |
C | ASN162 |
C | PHE166 |
C | HOH713 |
C | HOH727 |
A | VAL28 |
A | ALA29 |
site_id | AC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE FUA A 702 |
Chain | Residue |
A | THR93 |
A | TYR133 |
A | PHE134 |
A | PHE144 |
A | SER146 |
A | VAL160 |
A | ASN162 |
A | PHE166 |
A | HOH813 |
A | HOH830 |
A | HOH834 |
B | PHE25 |
B | VAL28 |
B | ALA29 |
B | HIS193 |
site_id | AC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE FUA B 703 |
Chain | Residue |
B | THR93 |
B | SER104 |
B | TYR133 |
B | PHE134 |
B | PHE144 |
B | SER146 |
B | VAL160 |
B | ASN162 |
B | PHE166 |
B | HOH713 |
C | PHE25 |
C | VAL28 |
C | ALA29 |
C | HIS193 |
site_id | AC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE FUA F 704 |
Chain | Residue |
D | VAL28 |
D | ALA29 |
D | HIS193 |
F | THR93 |
F | TYR133 |
F | PHE134 |
F | PHE144 |
F | SER146 |
F | ASN162 |
F | PHE166 |
F | HOH708 |
F | HOH718 |
site_id | AC6 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE FUA D 705 |
Chain | Residue |
D | THR93 |
D | TYR133 |
D | PHE134 |
D | PHE144 |
D | SER146 |
D | PHE156 |
D | LEU158 |
D | ASN162 |
D | PHE166 |
D | HOH718 |
D | HOH721 |
E | PHE25 |
E | VAL28 |
E | ALA29 |
E | HIS193 |
site_id | AC7 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE FUA E 706 |
Chain | Residue |
E | THR93 |
E | SER104 |
E | TYR133 |
E | PHE134 |
E | PHE144 |
E | SER146 |
E | ASN162 |
E | PHE166 |
E | HOH726 |
E | HOH745 |
F | PHE25 |
F | VAL28 |
F | ALA29 |
F | HIS193 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE FUA I 707 |
Chain | Residue |
I | PHE156 |
I | VAL160 |
I | ASN162 |
I | PHE166 |
I | HOH714 |
I | HOH719 |
G | VAL28 |
G | ALA29 |
G | HIS193 |
I | THR93 |
I | TYR133 |
I | PHE134 |
I | SER146 |
site_id | AC9 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE FUA G 708 |
Chain | Residue |
G | THR93 |
G | PHE102 |
G | SER104 |
G | TYR133 |
G | PHE134 |
G | PHE138 |
G | PHE144 |
G | SER146 |
G | PHE156 |
G | LEU158 |
G | ASN162 |
G | PHE166 |
G | HOH721 |
G | HOH730 |
H | PHE25 |
H | VAL28 |
H | ALA29 |
H | HIS193 |
site_id | BC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE FUA H 709 |
Chain | Residue |
H | THR93 |
H | TYR133 |
H | SER146 |
H | PHE156 |
H | LEU158 |
H | VAL160 |
H | ASN162 |
H | PHE166 |
H | HOH777 |
H | HOH783 |
I | PHE25 |
I | VAL28 |
I | ALA29 |
I | HIS193 |
I | HOH734 |
site_id | BC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE FUA L 710 |
Chain | Residue |
J | VAL28 |
J | ALA29 |
J | HIS193 |
L | THR93 |
L | PHE102 |
L | SER104 |
L | TYR133 |
L | SER146 |
L | PHE156 |
L | LEU158 |
L | VAL160 |
L | ASN162 |
L | PHE166 |
L | HOH717 |
L | HOH730 |
site_id | BC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE FUA J 711 |
Chain | Residue |
J | THR93 |
J | SER104 |
J | TYR133 |
J | PHE138 |
J | SER146 |
J | PHE156 |
J | LEU158 |
J | VAL160 |
J | ASN162 |
J | PHE166 |
J | HOH737 |
K | VAL28 |
K | ALA29 |
K | HIS193 |
site_id | BC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE FUA K 712 |
Chain | Residue |
K | THR93 |
K | SER104 |
K | TYR133 |
K | SER146 |
K | PHE156 |
K | LEU158 |
K | VAL160 |
K | ASN162 |
K | PHE166 |
K | HOH731 |
L | VAL28 |
L | ALA29 |
L | HIS193 |
Functional Information from PROSITE/UniProt
site_id | PS00100 |
Number of Residues | 11 |
Details | CAT Chloramphenicol acetyltransferase active site. QVHHAvcDGFH |
Chain | Residue | Details |
A | GLN190-HIS200 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | HIS193 | |
J | HIS193 | |
K | HIS193 | |
L | HIS193 | |
B | HIS193 | |
C | HIS193 | |
D | HIS193 | |
E | HIS193 | |
F | HIS193 | |
G | HIS193 | |
H | HIS193 | |
I | HIS193 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
A | HIS193 | |
A | ARG18 | |
A | ASP197 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
B | HIS193 | |
B | ARG18 | |
B | ASP197 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
C | HIS193 | |
C | ARG18 | |
C | ASP197 |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
D | HIS193 | |
D | ARG18 | |
D | ASP197 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
E | HIS193 | |
E | ARG18 | |
E | ASP197 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
F | HIS193 | |
F | ARG18 | |
F | ASP197 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
G | HIS193 | |
G | ARG18 | |
G | ASP197 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
H | HIS193 | |
H | ARG18 | |
H | ASP197 |
site_id | CSA9 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
I | HIS193 | |
I | ARG18 | |
I | ASP197 |
site_id | CSA10 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
J | HIS193 | |
J | ARG18 | |
J | ASP197 |
site_id | CSA11 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
K | HIS193 | |
K | ARG18 | |
K | ASP197 |
site_id | CSA12 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 3cla |
Chain | Residue | Details |
L | HIS193 | |
L | ARG18 | |
L | ASP197 |