1Q23
Crystal structure of Chloramphenicol acetyltransferase I complexed with Fusidic acid at 2.18 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| B | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| C | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| D | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| E | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| F | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| G | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| H | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| I | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| J | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| K | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
| L | 0008811 | molecular_function | chloramphenicol O-acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 801 |
| Chain | Residue |
| A | ASN68 |
| A | HOH817 |
| A | HOH840 |
| A | HOH858 |
| H | ASN68 |
| H | HOH732 |
| H | HOH737 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FUA C 701 |
| Chain | Residue |
| A | HIS193 |
| C | THR93 |
| C | PHE102 |
| C | SER104 |
| C | TYR133 |
| C | PHE134 |
| C | PHE144 |
| C | SER146 |
| C | PHE156 |
| C | ASN162 |
| C | PHE166 |
| C | HOH713 |
| C | HOH727 |
| A | VAL28 |
| A | ALA29 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FUA A 702 |
| Chain | Residue |
| A | THR93 |
| A | TYR133 |
| A | PHE134 |
| A | PHE144 |
| A | SER146 |
| A | VAL160 |
| A | ASN162 |
| A | PHE166 |
| A | HOH813 |
| A | HOH830 |
| A | HOH834 |
| B | PHE25 |
| B | VAL28 |
| B | ALA29 |
| B | HIS193 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE FUA B 703 |
| Chain | Residue |
| B | THR93 |
| B | SER104 |
| B | TYR133 |
| B | PHE134 |
| B | PHE144 |
| B | SER146 |
| B | VAL160 |
| B | ASN162 |
| B | PHE166 |
| B | HOH713 |
| C | PHE25 |
| C | VAL28 |
| C | ALA29 |
| C | HIS193 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FUA F 704 |
| Chain | Residue |
| D | VAL28 |
| D | ALA29 |
| D | HIS193 |
| F | THR93 |
| F | TYR133 |
| F | PHE134 |
| F | PHE144 |
| F | SER146 |
| F | ASN162 |
| F | PHE166 |
| F | HOH708 |
| F | HOH718 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FUA D 705 |
| Chain | Residue |
| D | THR93 |
| D | TYR133 |
| D | PHE134 |
| D | PHE144 |
| D | SER146 |
| D | PHE156 |
| D | LEU158 |
| D | ASN162 |
| D | PHE166 |
| D | HOH718 |
| D | HOH721 |
| E | PHE25 |
| E | VAL28 |
| E | ALA29 |
| E | HIS193 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE FUA E 706 |
| Chain | Residue |
| E | THR93 |
| E | SER104 |
| E | TYR133 |
| E | PHE134 |
| E | PHE144 |
| E | SER146 |
| E | ASN162 |
| E | PHE166 |
| E | HOH726 |
| E | HOH745 |
| F | PHE25 |
| F | VAL28 |
| F | ALA29 |
| F | HIS193 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FUA I 707 |
| Chain | Residue |
| I | PHE156 |
| I | VAL160 |
| I | ASN162 |
| I | PHE166 |
| I | HOH714 |
| I | HOH719 |
| G | VAL28 |
| G | ALA29 |
| G | HIS193 |
| I | THR93 |
| I | TYR133 |
| I | PHE134 |
| I | SER146 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE FUA G 708 |
| Chain | Residue |
| G | THR93 |
| G | PHE102 |
| G | SER104 |
| G | TYR133 |
| G | PHE134 |
| G | PHE138 |
| G | PHE144 |
| G | SER146 |
| G | PHE156 |
| G | LEU158 |
| G | ASN162 |
| G | PHE166 |
| G | HOH721 |
| G | HOH730 |
| H | PHE25 |
| H | VAL28 |
| H | ALA29 |
| H | HIS193 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FUA H 709 |
| Chain | Residue |
| H | THR93 |
| H | TYR133 |
| H | SER146 |
| H | PHE156 |
| H | LEU158 |
| H | VAL160 |
| H | ASN162 |
| H | PHE166 |
| H | HOH777 |
| H | HOH783 |
| I | PHE25 |
| I | VAL28 |
| I | ALA29 |
| I | HIS193 |
| I | HOH734 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FUA L 710 |
| Chain | Residue |
| J | VAL28 |
| J | ALA29 |
| J | HIS193 |
| L | THR93 |
| L | PHE102 |
| L | SER104 |
| L | TYR133 |
| L | SER146 |
| L | PHE156 |
| L | LEU158 |
| L | VAL160 |
| L | ASN162 |
| L | PHE166 |
| L | HOH717 |
| L | HOH730 |
| site_id | BC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE FUA J 711 |
| Chain | Residue |
| J | THR93 |
| J | SER104 |
| J | TYR133 |
| J | PHE138 |
| J | SER146 |
| J | PHE156 |
| J | LEU158 |
| J | VAL160 |
| J | ASN162 |
| J | PHE166 |
| J | HOH737 |
| K | VAL28 |
| K | ALA29 |
| K | HIS193 |
| site_id | BC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FUA K 712 |
| Chain | Residue |
| K | THR93 |
| K | SER104 |
| K | TYR133 |
| K | SER146 |
| K | PHE156 |
| K | LEU158 |
| K | VAL160 |
| K | ASN162 |
| K | PHE166 |
| K | HOH731 |
| L | VAL28 |
| L | ALA29 |
| L | HIS193 |
Functional Information from PROSITE/UniProt
| site_id | PS00100 |
| Number of Residues | 11 |
| Details | CAT Chloramphenicol acetyltransferase active site. QVHHAvcDGFH |
| Chain | Residue | Details |
| A | GLN190-HIS200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| A | HIS193 | |
| A | ARG18 | |
| A | ASP197 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| J | HIS193 | |
| J | ARG18 | |
| J | ASP197 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| K | HIS193 | |
| K | ARG18 | |
| K | ASP197 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| L | HIS193 | |
| L | ARG18 | |
| L | ASP197 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| B | HIS193 | |
| B | ARG18 | |
| B | ASP197 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| C | HIS193 | |
| C | ARG18 | |
| C | ASP197 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| D | HIS193 | |
| D | ARG18 | |
| D | ASP197 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| E | HIS193 | |
| E | ARG18 | |
| E | ASP197 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| F | HIS193 | |
| F | ARG18 | |
| F | ASP197 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| G | HIS193 | |
| G | ARG18 | |
| G | ASP197 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| H | HIS193 | |
| H | ARG18 | |
| H | ASP197 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 3cla |
| Chain | Residue | Details |
| I | HIS193 | |
| I | ARG18 | |
| I | ASP197 |
