1Q1N

APO AND HOLO STRUCTURES OF AN NADP(H)-DEPENDENT CINNAMYL ALCOHOL DEHYDROGENASE FROM SACCHAROMYCES CEREVISIAE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005575	cellular_component	cellular_component
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006066	biological_process	alcohol metabolic process
A	0006081	biological_process	aldehyde metabolic process
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0008270	molecular_function	zinc ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0033833	molecular_function	hydroxymethylfurfural reductase (NADH) activity
A	0033845	molecular_function	hydroxymethylfurfural reductase (NADPH) activity
A	0033859	biological_process	furaldehyde metabolic process
A	0045551	molecular_function	cinnamyl-alcohol dehydrogenase activity
A	0046872	molecular_function	metal ion binding
A	0052675	molecular_function	3-methylbutanal reductase (NADPH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1501

Chain	Residue
A	CYS100
A	CYS103
A	CYS106
A	CYS114

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1502

Chain	Residue
A	CYS46
A	SER48
A	HIS68
A	CYS163

---

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEiVGKvvklGpkS

Chain	Residue	Details
A	GLY67-SER81

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15289102","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q1N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15289102","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15289102","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15289102","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q1N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15289102","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
A	TRP57

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
A	SER48
A	HIS51

---