1Q19

Carbapenam Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004066	molecular_function	asparagine synthase (glutamine-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006529	biological_process	asparagine biosynthetic process
A	0016874	molecular_function	ligase activity
A	0017000	biological_process	antibiotic biosynthetic process
B	0004066	molecular_function	asparagine synthase (glutamine-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006529	biological_process	asparagine biosynthetic process
B	0016874	molecular_function	ligase activity
B	0017000	biological_process	antibiotic biosynthetic process
C	0004066	molecular_function	asparagine synthase (glutamine-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006529	biological_process	asparagine biosynthetic process
C	0016874	molecular_function	ligase activity
C	0017000	biological_process	antibiotic biosynthetic process
D	0004066	molecular_function	asparagine synthase (glutamine-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006529	biological_process	asparagine biosynthetic process
D	0016874	molecular_function	ligase activity
D	0017000	biological_process	antibiotic biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 504

Chain	Residue
A	ILE444
A	APC505
A	HOH507

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 504

Chain	Residue
D	SER246
D	ILE444
D	APC505
D	HOH553

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 504

Chain	Residue
B	APC505
B	HOH548
B	SER246
B	ILE444

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 504

Chain	Residue
C	SER246
C	ILE444
C	APC505

---

site_id	AC5
Number of Residues	25
Details	BINDING SITE FOR RESIDUE APC A 505

Chain	Residue
A	PRO244
A	LEU245
A	SER246
A	GLY248
A	LEU249
A	ASP250
A	SER251
A	TYR268
A	SER269
A	ILE270
A	LEU327
A	THR343
A	GLY344
A	TYR345
A	ASP348
A	LYS421
A	LYS443
A	ILE444
A	GLY445
A	ILE446
A	MG504
A	SSC506
A	HOH507
A	HOH560
A	HOH598

---

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE APC B 505

Chain	Residue
B	PRO244
B	LEU245
B	SER246
B	GLY248
B	LEU249
B	ASP250
B	SER251
B	TYR268
B	SER269
B	ILE270
B	LEU327
B	GLY344
B	TYR345
B	ASP348
B	LYS421
B	LYS443
B	ILE444
B	GLY445
B	ILE446
B	MG504
B	SSC506
B	HOH507
B	HOH554

---

site_id	AC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE APC C 505

Chain	Residue
C	PRO244
C	LEU245
C	SER246
C	GLY248
C	LEU249
C	ASP250
C	SER251
C	TYR268
C	SER269
C	ILE270
C	THR343
C	GLY344
C	TYR345
C	ASP348
C	LYS421
C	LYS442
C	ILE444
C	GLY445
C	ILE446
C	SER450
C	MG504
C	SSC506

---

site_id	AC8
Number of Residues	24
Details	BINDING SITE FOR RESIDUE APC D 505

Chain	Residue
D	LYS443
D	ILE444
D	GLY445
D	ILE446
D	MG504
D	SSC506
D	HOH529
D	HOH554
D	HOH565
D	PRO244
D	LEU245
D	SER246
D	GLY248
D	LEU249
D	ASP250
D	SER251
D	TYR268
D	SER269
D	ILE270
D	LEU327
D	THR343
D	GLY344
D	ASP348
D	LYS421

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SSC A 506

Chain	Residue
A	ILE323
A	TYR345
A	GLY346
A	LEU349
A	ARG374
A	GLU380
A	APC505
A	HOH561

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SSC B 506

Chain	Residue
B	ILE323
B	TYR345
B	GLY346
B	ASP348
B	LEU349
B	GLN371
B	APC505
B	HOH543

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SSC D 506

Chain	Residue
D	LEU319
D	ILE323
D	TYR345
D	GLY346
D	ASP348
D	GLN371
D	APC505
D	HOH554

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SSC C 506

Chain	Residue
C	LEU319
C	TYR345
C	GLY346
C	GLN371
C	ARG374
C	APC505
C	HOH527
C	HOH543

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:19371088

Chain	Residue	Details
A	TYR345
B	TYR345
C	TYR345
D	TYR345

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:19371088

Chain	Residue	Details
A	GLU380
B	GLU380
C	GLU380
D	GLU380

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:12890666

Chain	Residue	Details
A	PRO244
B	ILE270
B	GLY344
B	GLY346
B	GLN371
B	ARG374
B	LYS421
B	ILE444
C	PRO244
C	ILE270
C	GLY344
A	ILE270
C	GLY346
C	GLN371
C	ARG374
C	LYS421
C	ILE444
D	PRO244
D	ILE270
D	GLY344
D	GLY346
D	GLN371
A	GLY344
D	ARG374
D	LYS421
D	ILE444
A	GLY346
A	GLN371
A	ARG374
A	LYS421
A	ILE444
B	PRO244

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