Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1Q12

Crystal Structure of the ATP-bound E. coli MalK

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0008643	biological_process	carbohydrate transport
A	0015423	molecular_function	ABC-type maltose transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022857	molecular_function	transmembrane transporter activity
A	0032991	cellular_component	protein-containing complex
A	0034763	biological_process	negative regulation of transmembrane transport
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0071702	biological_process	organic substance transport
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140359	molecular_function	ABC-type transporter activity
A	1902344	biological_process	negative regulation of maltose transport
A	1904981	biological_process	maltose transmembrane transport
A	1990060	cellular_component	maltose transport complex
A	1990154	cellular_component	enzyme IIA-maltose transporter complex
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0008643	biological_process	carbohydrate transport
B	0015423	molecular_function	ABC-type maltose transporter activity
B	0015768	biological_process	maltose transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0022857	molecular_function	transmembrane transporter activity
B	0032991	cellular_component	protein-containing complex
B	0034763	biological_process	negative regulation of transmembrane transport
B	0042956	biological_process	maltodextrin transmembrane transport
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B	0055085	biological_process	transmembrane transport
B	0071702	biological_process	organic substance transport
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0140359	molecular_function	ABC-type transporter activity
B	1902344	biological_process	negative regulation of maltose transport
B	1904981	biological_process	maltose transmembrane transport
B	1990060	cellular_component	maltose transport complex
B	1990154	cellular_component	enzyme IIA-maltose transporter complex
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0008643	biological_process	carbohydrate transport
C	0015423	molecular_function	ABC-type maltose transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0022857	molecular_function	transmembrane transporter activity
C	0032991	cellular_component	protein-containing complex
C	0034763	biological_process	negative regulation of transmembrane transport
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0071702	biological_process	organic substance transport
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140359	molecular_function	ABC-type transporter activity
C	1902344	biological_process	negative regulation of maltose transport
C	1904981	biological_process	maltose transmembrane transport
C	1990060	cellular_component	maltose transport complex
C	1990154	cellular_component	enzyme IIA-maltose transporter complex
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0008643	biological_process	carbohydrate transport
D	0015423	molecular_function	ABC-type maltose transporter activity
D	0015768	biological_process	maltose transport
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0022857	molecular_function	transmembrane transporter activity
D	0032991	cellular_component	protein-containing complex
D	0034763	biological_process	negative regulation of transmembrane transport
D	0042956	biological_process	maltodextrin transmembrane transport
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D	0055085	biological_process	transmembrane transport
D	0071702	biological_process	organic substance transport
D	0140297	molecular_function	DNA-binding transcription factor binding
D	0140359	molecular_function	ABC-type transporter activity
D	1902344	biological_process	negative regulation of maltose transport
D	1904981	biological_process	maltose transmembrane transport
D	1990060	cellular_component	maltose transport complex
D	1990154	cellular_component	enzyme IIA-maltose transporter complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP B 382

Chain	Residue
A	ARG129
B	VAL18
B	SER38
B	GLY39
B	CYS40
B	GLY41
B	LYS42
B	SER43
B	THR44
B	HIS192
A	ALA133
A	LEU134
A	SER135
A	GLY136
A	GLY137
A	GLN138
A	ASN163
B	TRP13

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP A 382

Chain	Residue
A	TRP13
A	VAL18
A	SER38
A	GLY39
A	CYS40
A	GLY41
A	LYS42
A	SER43
A	THR44
A	HIS192
B	ARG129
B	LYS132
B	ALA133
B	SER135
B	GLY136
B	GLY137
B	GLN138
B	ASN163

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP D 382

Chain	Residue
C	ARG129
C	ALA133
C	LEU134
C	SER135
C	GLY136
C	GLY137
C	GLN138
C	ASN163
D	TRP13
D	VAL18
D	SER38
D	GLY39
D	CYS40
D	GLY41
D	LYS42
D	SER43
D	THR44
D	HIS192

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP C 382

Chain	Residue
C	TRP13
C	VAL18
C	SER38
C	GLY39
C	CYS40
C	GLY41
C	LYS42
C	SER43
C	THR44
C	HIS192
D	ARG129
D	LYS132
D	ALA133
D	SER135
D	GLY136
D	GLY137
D	GLN138
D	ASN163

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRVAIGRTL

Chain	Residue	Details
A	LEU134-LEU148

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01709

Chain	Residue	Details
A	GLY36
B	GLY36
C	GLY36
D	GLY36

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)