1Q11

Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004831	molecular_function	tyrosine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006437	biological_process	tyrosyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	HIS305
A	PRO306
A	GLY307
A	ASP308
A	HOH1044
A	HOH1186
A	HOH1263

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 701

Chain	Residue
A	THR45
A	TYR52
A	TYR97
A	HOH1011
A	THR42
A	ALA43

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TYE A 401

Chain	Residue
A	TYR39
A	GLY41
A	LEU72
A	ALA74
A	HIS77
A	VAL152
A	TYR166
A	GLN170
A	ASP173
A	GLN182
A	GLN188
A	HOH1165

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 601

Chain	Residue
A	HIS12
A	ARG16
A	HOH1155

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 602

Chain	Residue
A	LYS127
A	GLU128
A	HIS143
A	LYS146

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:25533949, ECO:0007744|PDB:4Q93

Chain	Residue	Details
A	TYR39
A	GLN170
A	ASP173

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14671330, ECO:0007744|PDB:4QBT

Chain	Residue	Details
A	TYR166
A	GLN188

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	MET1

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylglycine; in Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	GLY2

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS197
A	LYS206

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER205

---