1PZG
T.gondii LDH1 complexed with APAD and sulfate at 1.6 Angstroms
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0006089 | biological_process | lactate metabolic process |
A | 0006090 | biological_process | pyruvate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
B | 0006089 | biological_process | lactate metabolic process |
B | 0006090 | biological_process | pyruvate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0000166 | molecular_function | nucleotide binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
C | 0006089 | biological_process | lactate metabolic process |
C | 0006090 | biological_process | pyruvate metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0000166 | molecular_function | nucleotide binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
D | 0006089 | biological_process | lactate metabolic process |
D | 0006090 | biological_process | pyruvate metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 A 602 |
Chain | Residue |
A | TRP107 |
A | ARG109 |
A | ASN140 |
A | ARG171 |
A | HIS195 |
A | GLY236 |
A | ALA246 |
A | A3D601 |
A | HOH642 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SO4 B 604 |
Chain | Residue |
B | TRP107 |
B | ARG109 |
B | ASN140 |
B | LEU167 |
B | ARG171 |
B | HIS195 |
B | GLY236 |
B | ALA246 |
B | A3D603 |
B | HOH618 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 C 606 |
Chain | Residue |
C | TRP107 |
C | ARG109 |
C | ARG171 |
C | HIS195 |
C | GLY236 |
C | A3D605 |
C | HOH639 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 D 608 |
Chain | Residue |
D | TRP107 |
D | ARG109 |
D | LEU167 |
D | ARG171 |
D | HIS195 |
D | GLY236 |
D | ALA246 |
D | A3D607 |
D | HOH635 |
site_id | AC5 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE A3D A 601 |
Chain | Residue |
A | GLY29 |
A | MET30 |
A | ILE31 |
A | TYR52 |
A | ASP53 |
A | VAL54 |
A | VAL55 |
A | MET58 |
A | THR97 |
A | ALA98 |
A | GLY99 |
A | LEU100 |
A | THR101 |
A | ILE119 |
A | VAL138 |
A | THR139 |
A | ASN140 |
A | LEU142 |
A | MET163 |
A | LEU167 |
A | HIS195 |
A | ALA246 |
A | SO4602 |
A | HOH605 |
A | HOH610 |
A | HOH659 |
A | HOH678 |
A | HOH694 |
A | HOH710 |
A | HOH760 |
site_id | AC6 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE A3D B 603 |
Chain | Residue |
B | GLY29 |
B | MET30 |
B | ILE31 |
B | ASP53 |
B | VAL54 |
B | VAL55 |
B | MET58 |
B | THR97 |
B | ALA98 |
B | GLY99 |
B | LEU100 |
B | THR101 |
B | ILE119 |
B | VAL138 |
B | THR139 |
B | ASN140 |
B | LEU142 |
B | MET163 |
B | LEU167 |
B | HIS195 |
B | ALA246 |
B | PRO250 |
B | SO4604 |
B | HOH615 |
B | HOH619 |
B | HOH651 |
B | HOH686 |
B | HOH716 |
B | HOH744 |
B | HOH748 |
site_id | AC7 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE A3D C 605 |
Chain | Residue |
C | ASP53 |
C | VAL54 |
C | VAL55 |
C | MET58 |
C | THR97 |
C | ALA98 |
C | GLY99 |
C | LEU100 |
C | THR101 |
C | ILE119 |
C | VAL138 |
C | ASN140 |
C | LEU142 |
C | MET163 |
C | LEU167 |
C | HIS195 |
C | ALA246 |
C | SO4606 |
C | HOH613 |
C | HOH622 |
C | HOH694 |
C | HOH721 |
C | HOH723 |
C | GLY29 |
C | MET30 |
C | ILE31 |
C | TYR52 |
site_id | AC8 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE A3D D 607 |
Chain | Residue |
D | GLY29 |
D | MET30 |
D | ILE31 |
D | ASP53 |
D | VAL54 |
D | VAL55 |
D | MET58 |
D | THR97 |
D | ALA98 |
D | GLY99 |
D | LEU100 |
D | THR101 |
D | ILE119 |
D | VAL138 |
D | THR139 |
D | ASN140 |
D | LEU142 |
D | MET163 |
D | LEU167 |
D | HIS195 |
D | ALA246 |
D | SO4608 |
D | HOH612 |
D | HOH628 |
D | HOH645 |
D | HOH716 |
D | HOH727 |
D | HOH729 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
A | HIS195 | |
A | ASP168 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
B | HIS195 | |
B | ASP168 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
C | HIS195 | |
C | ASP168 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
D | HIS195 | |
D | ASP168 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
A | HIS195 | |
A | ARG171 | |
A | ASP168 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
B | HIS195 | |
B | ARG171 | |
B | ASP168 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
C | HIS195 | |
C | ARG171 | |
C | ASP168 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
D | HIS195 | |
D | ARG171 | |
D | ASP168 |