1PZ0

Structure of NADPH-dependent family 11 aldo-keto reductase AKR11A(holo)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 314

Chain	Residue
A	LEU268
A	ARG270
A	ILE273
A	HOH337
A	HOH406
A	HOH418

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site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAP A 313

Chain	Residue
A	ASN156
A	GLN175
A	TYR203
A	PHE204
A	PRO205
A	LEU206
A	VAL207
A	SER208
A	GLY209
A	ALA212
A	LYS214
A	PRO260
A	HOH320
A	HOH330
A	HOH332
A	HOH363
A	HOH453
A	HOH460
A	TYR58
A	HIS125
A	SER155

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Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LnemkkagkIRSIGVSNF

Chain	Residue	Details
A	LEU140-PHE157

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:15019785

Chain	Residue	Details
A	TYR58

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15019785

Chain	Residue	Details
A	SER155
A	GLN175
A	TYR203
A	LYS214

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Lowers pKa of active site Tyr => ECO:0000305|PubMed:15019785

Chain	Residue	Details
A	LYS84

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	TYR58
A	LYS84
A	ASP53
A	HIS125

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	TYR58
A	LYS84

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