1PZ0

Structure of NADPH-dependent family 11 aldo-keto reductase AKR11A(holo)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 314

Chain	Residue
A	LEU268
A	ARG270
A	ILE273
A	HOH337
A	HOH406
A	HOH418

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAP A 313

Chain	Residue
A	ASN156
A	GLN175
A	TYR203
A	PHE204
A	PRO205
A	LEU206
A	VAL207
A	SER208
A	GLY209
A	ALA212
A	LYS214
A	PRO260
A	HOH320
A	HOH330
A	HOH332
A	HOH363
A	HOH453
A	HOH460
A	TYR58
A	HIS125
A	SER155

---

Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LnemkkagkIRSIGVSNF

Chain	Residue	Details
A	LEU140-PHE157

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15019785","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15019785","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"source":"PubMed","id":"15019785","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	TYR58
A	LYS84
A	ASP53
A	HIS125

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	TYR58
A	LYS84

---