1PYF

Structure of NADPH-dependent family 11 aldo-keto reductase AKR11A(apo)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 315

Chain	Residue
A	LEU268
A	ARG270
A	ILE273
A	HOH343
A	HOH396
A	HOH400

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 313

Chain	Residue
A	PRO271
A	GLU272
A	ASP274
A	HOH368
A	HOH378
A	GLY7
A	ASN197
A	ILE198

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 314

Chain	Residue
A	GLU35
A	LYS38
A	ARG42
A	SER303
A	PHE304
A	HOH325
A	HOH347

---

Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LnemkkagkIRSIGVSNF

Chain	Residue	Details
A	LEU140-PHE157

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15019785","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15019785","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"source":"PubMed","id":"15019785","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	TYR58
A	LYS84
A	ASP53
A	HIS125

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	TYR58
A	LYS84

---