1PX9

Solution structure of the native CnErg1 Ergtoxin, a highly specific inhibitor of HERG channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0015459	molecular_function	potassium channel regulator activity
A	0019870	molecular_function	potassium channel inhibitor activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
A	0099106	molecular_function	ion channel regulator activity

Functional Information from PROSITE/UniProt

site_id	PS60026
Number of Residues	37
Details	ERGTX Ergtoxin family signature. CvdksrCaKygyyqeCqdCCknaghnggtCmffkCkC

Chain	Residue	Details
A	CYS5-CYS41

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Site: {"description":"May represent the binding site","evidences":[{"source":"PubMed","id":"12650941","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Key residue on the interacting surface with the channel","evidences":[{"source":"PubMed","id":"20600425","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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