1PVJ
Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0006508 | biological_process | proteolysis |
A | 0008234 | molecular_function | cysteine-type peptidase activity |
A | 0030430 | cellular_component | host cell cytoplasm |
A | 0034050 | biological_process | symbiont-induced defense-related programmed cell death |
A | 0042783 | biological_process | evasion of host immune response |
A | 0043655 | cellular_component | host extracellular space |
A | 0044164 | cellular_component | host cell cytosol |
A | 0052035 | biological_process | obsolete positive regulation by symbiont of host inflammatory response |
A | 0090729 | molecular_function | toxin activity |
A | 0140321 | biological_process | symbiont-mediated suppression of host autophagy |
B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
B | 0005576 | cellular_component | extracellular region |
B | 0006508 | biological_process | proteolysis |
B | 0008234 | molecular_function | cysteine-type peptidase activity |
B | 0030430 | cellular_component | host cell cytoplasm |
B | 0034050 | biological_process | symbiont-induced defense-related programmed cell death |
B | 0042783 | biological_process | evasion of host immune response |
B | 0043655 | cellular_component | host extracellular space |
B | 0044164 | cellular_component | host cell cytosol |
B | 0052035 | biological_process | obsolete positive regulation by symbiont of host inflammatory response |
B | 0090729 | molecular_function | toxin activity |
B | 0140321 | biological_process | symbiont-mediated suppression of host autophagy |
C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
C | 0005576 | cellular_component | extracellular region |
C | 0006508 | biological_process | proteolysis |
C | 0008234 | molecular_function | cysteine-type peptidase activity |
C | 0030430 | cellular_component | host cell cytoplasm |
C | 0034050 | biological_process | symbiont-induced defense-related programmed cell death |
C | 0042783 | biological_process | evasion of host immune response |
C | 0043655 | cellular_component | host extracellular space |
C | 0044164 | cellular_component | host cell cytosol |
C | 0052035 | biological_process | obsolete positive regulation by symbiont of host inflammatory response |
C | 0090729 | molecular_function | toxin activity |
C | 0140321 | biological_process | symbiont-mediated suppression of host autophagy |
D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
D | 0005576 | cellular_component | extracellular region |
D | 0006508 | biological_process | proteolysis |
D | 0008234 | molecular_function | cysteine-type peptidase activity |
D | 0030430 | cellular_component | host cell cytoplasm |
D | 0034050 | biological_process | symbiont-induced defense-related programmed cell death |
D | 0042783 | biological_process | evasion of host immune response |
D | 0043655 | cellular_component | host extracellular space |
D | 0044164 | cellular_component | host cell cytosol |
D | 0052035 | biological_process | obsolete positive regulation by symbiont of host inflammatory response |
D | 0090729 | molecular_function | toxin activity |
D | 0140321 | biological_process | symbiont-mediated suppression of host autophagy |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ZFB A 450 |
Chain | Residue |
A | GLU115 |
A | GLY339 |
A | HIS340 |
A | TRP359 |
A | ASN116 |
A | GLN162 |
A | ALA189 |
A | CYS192 |
A | SER279 |
A | SER280 |
A | GLY281 |
A | VAL337 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ZFB B 450 |
Chain | Residue |
B | GLU115 |
B | ASN116 |
B | GLN162 |
B | ALA189 |
B | CYS192 |
B | SER279 |
B | SER280 |
B | GLY281 |
B | VAL337 |
B | GLY339 |
B | HIS340 |
B | TRP359 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ZFB C 450 |
Chain | Residue |
C | GLU115 |
C | ASN116 |
C | GLN162 |
C | ALA189 |
C | CYS192 |
C | SER279 |
C | SER280 |
C | GLY281 |
C | VAL337 |
C | GLY339 |
C | HIS340 |
C | TRP359 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ZFB D 450 |
Chain | Residue |
D | GLU115 |
D | ASN116 |
D | GLN162 |
D | ALA189 |
D | CYS192 |
D | SER279 |
D | SER280 |
D | GLY281 |
D | VAL337 |
D | GLY339 |
D | HIS340 |
D | TRP359 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:19712682, ECO:0000269|PubMed:22645124, ECO:0000305|PubMed:8675287 |
Chain | Residue | Details |
A | CYS192 | |
B | CYS192 | |
C | CYS192 | |
D | CYS192 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:19712682 |
Chain | Residue | Details |
A | HIS340 | |
B | HIS340 | |
C | HIS340 | |
D | HIS340 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22645124, ECO:0007744|PDB:4D8E |
Chain | Residue | Details |
A | GLN162 | |
D | GLN162 | |
D | SER282 | |
D | HIS340 | |
A | SER282 | |
A | HIS340 | |
B | GLN162 | |
B | SER282 | |
B | HIS340 | |
C | GLN162 | |
C | SER282 | |
C | HIS340 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: covalent => ECO:0000269|PubMed:19712682, ECO:0000269|PubMed:22645124, ECO:0007744|PDB:2UZJ, ECO:0007744|PDB:4D8E |
Chain | Residue | Details |
A | CYS192 | |
B | CYS192 | |
C | CYS192 | |
D | CYS192 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000305|PubMed:22645124, ECO:0007744|PDB:4D8I |
Chain | Residue | Details |
A | GLY339 | |
B | GLY339 | |
C | GLY339 | |
D | GLY339 |
site_id | SWS_FT_FI6 |
Number of Residues | 20 |
Details | SITE: Cleavage; by autolysis => ECO:0000269|PubMed:10429198 |
Chain | Residue | Details |
A | LYS53 | |
B | LYS145 | |
C | LYS53 | |
C | ASN68 | |
C | LYS129 | |
C | ALA139 | |
C | LYS145 | |
D | LYS53 | |
D | ASN68 | |
D | LYS129 | |
D | ALA139 | |
A | ASN68 | |
D | LYS145 | |
A | LYS129 | |
A | ALA139 | |
A | LYS145 | |
B | LYS53 | |
B | ASN68 | |
B | LYS129 | |
B | ALA139 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Cysteine methyl disulfide; in zymogen form => ECO:0000269|PubMed:6381494 |
Chain | Residue | Details |
A | CYS192 | |
B | CYS192 | |
C | CYS192 | |
D | CYS192 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dki |
Chain | Residue | Details |
A | CYS192 | |
A | HIS340 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dki |
Chain | Residue | Details |
B | CYS192 | |
B | HIS340 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dki |
Chain | Residue | Details |
C | CYS192 | |
C | HIS340 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dki |
Chain | Residue | Details |
D | CYS192 | |
D | HIS340 |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 598 |
Chain | Residue | Details |
A | CYS192 | |
A | HIS340 | proton shuttle (general acid/base) |
A | TRP357 |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 598 |
Chain | Residue | Details |
B | CYS192 | |
B | HIS340 | proton shuttle (general acid/base) |
B | TRP357 |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 598 |
Chain | Residue | Details |
C | CYS192 | |
C | HIS340 | proton shuttle (general acid/base) |
C | TRP357 |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 598 |
Chain | Residue | Details |
D | CYS192 | |
D | HIS340 | proton shuttle (general acid/base) |
D | TRP357 |