Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1PVJ

Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0030430	cellular_component	host cell cytoplasm
A	0034050	biological_process	symbiont-induced defense-related programmed cell death
A	0035893	biological_process	obsolete suppression of platelet aggregation in another organism
A	0042783	biological_process	symbiont-mediated evasion of host immune response
A	0043655	cellular_component	host extracellular space
A	0044164	cellular_component	host cell cytosol
A	0052035	biological_process	obsolete positive regulation by symbiont of host inflammatory response
A	0090729	molecular_function	toxin activity
A	0140321	biological_process	symbiont-mediated suppression of host autophagy
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0030430	cellular_component	host cell cytoplasm
B	0034050	biological_process	symbiont-induced defense-related programmed cell death
B	0035893	biological_process	obsolete suppression of platelet aggregation in another organism
B	0042783	biological_process	symbiont-mediated evasion of host immune response
B	0043655	cellular_component	host extracellular space
B	0044164	cellular_component	host cell cytosol
B	0052035	biological_process	obsolete positive regulation by symbiont of host inflammatory response
B	0090729	molecular_function	toxin activity
B	0140321	biological_process	symbiont-mediated suppression of host autophagy
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008234	molecular_function	cysteine-type peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0030430	cellular_component	host cell cytoplasm
C	0034050	biological_process	symbiont-induced defense-related programmed cell death
C	0035893	biological_process	obsolete suppression of platelet aggregation in another organism
C	0042783	biological_process	symbiont-mediated evasion of host immune response
C	0043655	cellular_component	host extracellular space
C	0044164	cellular_component	host cell cytosol
C	0052035	biological_process	obsolete positive regulation by symbiont of host inflammatory response
C	0090729	molecular_function	toxin activity
C	0140321	biological_process	symbiont-mediated suppression of host autophagy
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0005576	cellular_component	extracellular region
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008234	molecular_function	cysteine-type peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0030430	cellular_component	host cell cytoplasm
D	0034050	biological_process	symbiont-induced defense-related programmed cell death
D	0035893	biological_process	obsolete suppression of platelet aggregation in another organism
D	0042783	biological_process	symbiont-mediated evasion of host immune response
D	0043655	cellular_component	host extracellular space
D	0044164	cellular_component	host cell cytosol
D	0052035	biological_process	obsolete positive regulation by symbiont of host inflammatory response
D	0090729	molecular_function	toxin activity
D	0140321	biological_process	symbiont-mediated suppression of host autophagy

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ZFB A 450

Chain	Residue
A	GLU115
A	GLY339
A	HIS340
A	TRP359
A	ASN116
A	GLN162
A	ALA189
A	CYS192
A	SER279
A	SER280
A	GLY281
A	VAL337

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ZFB B 450

Chain	Residue
B	GLU115
B	ASN116
B	GLN162
B	ALA189
B	CYS192
B	SER279
B	SER280
B	GLY281
B	VAL337
B	GLY339
B	HIS340
B	TRP359

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ZFB C 450

Chain	Residue
C	GLU115
C	ASN116
C	GLN162
C	ALA189
C	CYS192
C	SER279
C	SER280
C	GLY281
C	VAL337
C	GLY339
C	HIS340
C	TRP359

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ZFB D 450

Chain	Residue
D	GLU115
D	ASN116
D	GLN162
D	ALA189
D	CYS192
D	SER279
D	SER280
D	GLY281
D	VAL337
D	GLY339
D	HIS340
D	TRP359

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19712682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8675287","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"19712682","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4D8E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"19712682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D8E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22645124","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4D8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"10429198","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Cysteine methyl disulfide; in zymogen form","evidences":[{"source":"PubMed","id":"6381494","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dki

Chain	Residue	Details
A	CYS192
A	HIS340

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dki

Chain	Residue	Details
B	CYS192
B	HIS340

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1dki

Chain	Residue	Details
C	CYS192
C	HIS340

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1dki

Chain	Residue	Details
D	CYS192
D	HIS340

site_id	MCSA1
Number of Residues	3
Details	M-CSA 598

Chain	Residue	Details
A	CYS192
A	HIS340	proton shuttle (general acid/base)
A	TRP357

site_id	MCSA2
Number of Residues	3
Details	M-CSA 598

Chain	Residue	Details
B	CYS192
B	HIS340	proton shuttle (general acid/base)
B	TRP357

site_id	MCSA3
Number of Residues	3
Details	M-CSA 598

Chain	Residue	Details
C	CYS192
C	HIS340	proton shuttle (general acid/base)
C	TRP357

site_id	MCSA4
Number of Residues	3
Details	M-CSA 598

Chain	Residue	Details
D	CYS192
D	HIS340	proton shuttle (general acid/base)
D	TRP357

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)