1PVA

COMPARISON BETWEEN THE CRYSTAL AND THE SOLUTION STRUCTURES OF THE EF HAND PARVALBUMIN (ALPHA COMPONENT FROM PIKE MUSCLE)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005737	cellular_component	cytoplasm
A	0046872	molecular_function	metal ion binding
B	0005509	molecular_function	calcium ion binding
B	0005737	cellular_component	cytoplasm
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 110

Chain	Residue
A	ASP90
A	ASP92
A	ASP94
A	LYS96
A	GLU101
A	HOH118

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 111

Chain	Residue
A	ASP51
A	ASP53
A	SER55
A	PHE57
A	GLU59
A	GLU62

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 110

Chain	Residue
B	ASP90
B	ASP92
B	ASP94
B	LYS96
B	GLU101
B	HOH118

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 111

Chain	Residue
B	ASP51
B	ASP53
B	SER55
B	PHE57
B	GLU59
B	GLU62

---

site_id	ACD
Number of Residues	12
Details	CATION BINDING SITE OCCUPIED BY CA2+ (A 111)

Chain	Residue
A	ASP51
A	GLU60
A	GLU61
A	GLU62
A	ALA52
A	ASP53
A	ALA54
A	SER55
A	GLY56
A	PHE57
A	ILE58
A	GLU59

---

site_id	AEF
Number of Residues	12
Details	CATION BINDING SITE OCCUPIED BY CA2+ (A 110)

Chain	Residue
A	ASP90
A	LYS91
A	ASP92
A	GLY93
A	ASP94
A	GLY95
A	LYS96
A	ILE97
A	GLY98
A	ILE99
A	ASP100
A	GLU101

---

site_id	BCD
Number of Residues	12
Details	CATION BINDING SITE OCCUPIED BY CA2+ (B 111)

Chain	Residue
B	ASP51
B	ALA52
B	ASP53
B	ALA54
B	SER55
B	GLY56
B	PHE57
B	ILE58
B	GLU59
B	GLU60
B	GLU61
B	GLU62

---

site_id	BEF
Number of Residues	12
Details	CATION BINDING SITE OCCUPIED BY CA2+ (B 110)

Chain	Residue
B	ASP90
B	LYS91
B	ASP92
B	GLY93
B	ASP94
B	GLY95
B	LYS96
B	ILE97
B	GLY98
B	ILE99
B	ASP100
B	GLU101

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DADASGFIEeeEL

Chain	Residue	Details
A	ASP51-LEU63
A	ASP90-PHE102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-1994","submissionDatabase":"PDB data bank","title":"Comparison between the Crystal and the Solution Structures of the EF Hand Parvalbumin.","authors":["Padilla A.","Cave A.","Parello J.","Etienne G.","Baldellon C."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-1995","submissionDatabase":"PDB data bank","title":"Comparison between the crystal and the solution structures of the ef hand parvalbumin (alpha component from pike muscle).","authors":["Roquet F.","Rambaud J.","Declercq J.P.","Tinant B.","Baldellon C.","Padilla A.","Cave A.","Parello J."]}},{"source":"PDB","id":"1PVA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PAT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-1994","submissionDatabase":"PDB data bank","title":"Comparison between the Crystal and the Solution Structures of the EF Hand Parvalbumin.","authors":["Padilla A.","Cave A.","Parello J.","Etienne G.","Baldellon C."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-1995","submissionDatabase":"PDB data bank","title":"Comparison between the crystal and the solution structures of the ef hand parvalbumin (alpha component from pike muscle).","authors":["Roquet F.","Rambaud J.","Declercq J.P.","Tinant B.","Baldellon C.","Padilla A.","Cave A.","Parello J."]}},{"source":"PDB","id":"1PVA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PAT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-1994","submissionDatabase":"PDB data bank","title":"Comparison between the Crystal and the Solution Structures of the EF Hand Parvalbumin.","authors":["Padilla A.","Cave A.","Parello J.","Etienne G.","Baldellon C."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-1995","submissionDatabase":"PDB data bank","title":"Comparison between the crystal and the solution structures of the ef hand parvalbumin (alpha component from pike muscle).","authors":["Roquet F.","Rambaud J.","Declercq J.P.","Tinant B.","Baldellon C.","Padilla A.","Cave A.","Parello J."]}},{"source":"PDB","id":"1PVA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PAS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-1994","submissionDatabase":"PDB data bank","title":"Comparison between the Crystal and the Solution Structures of the EF Hand Parvalbumin.","authors":["Padilla A.","Cave A.","Parello J.","Etienne G.","Baldellon C."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-1995","submissionDatabase":"PDB data bank","title":"Comparison between the crystal and the solution structures of the ef hand parvalbumin (alpha component from pike muscle).","authors":["Roquet F.","Rambaud J.","Declercq J.P.","Tinant B.","Baldellon C.","Padilla A.","Cave A.","Parello J."]}},{"source":"PDB","id":"1PVA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PAS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"4751989","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---