1PUF

Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0003677	molecular_function	DNA binding
A	0006355	biological_process	regulation of DNA-templated transcription
B	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
B	0003677	molecular_function	DNA binding
B	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. VArlLnLTerQVKIWFqNrrmkmK

Chain	Residue	Details
A	VAL238-LYS261
B	LEU269-LYS292

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	62
Details	DNA_BIND: Homeobox; TALE-type => ECO:0000255|PROSITE-ProRule:PRU00108

Chain	Residue	Details
B	ALA233-ILE295

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Required for binding to the NFIL3 promoter => ECO:0000250|UniProtKB:P41778

Chain	Residue	Details
B	ASN286

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