1PT0

Unprocessed Pyruvoyl Dependent Aspartate Decarboxylase with an Alanine insertion at position 26

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004068	molecular_function	aspartate 1-decarboxylase activity
A	0006523	biological_process	alanine biosynthetic process
B	0004068	molecular_function	aspartate 1-decarboxylase activity
B	0006523	biological_process	alanine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 200

Chain	Residue
A	SER25
B	ARG55
A	ALA26
A	THR58
A	ASN73
A	GLY74
A	ALA75
A	ALA76
A	HOH247
B	TRP48

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Schiff-base intermediate with substrate; via pyruvic acid","evidences":[{"source":"PubMed","id":"9546220","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Pyruvic acid (Ser)","evidences":[{"source":"PubMed","id":"9546220","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
B	LYS9

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
A	TYR59

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
A	LYS9
B	TYR59

---

site_id	MCSA1
Number of Residues	3
Details	M-CSA 409

Chain	Residue	Details
A	LYS9	electrostatic stabiliser
A	SER25	covalently attached, electrofuge, electrophile
A	TYR59	activator, increase nucleophilicity, proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 409

Chain	Residue	Details
B	LYS9	electrostatic stabiliser
B	SER25	covalently attached, electrofuge, electrophile
B	TYR59	activator, increase nucleophilicity, proton acceptor, proton donor

---