1PSR

HUMAN PSORIASIN (S100A7)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0001525	biological_process	angiogenesis
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0008270	molecular_function	zinc ion binding
A	0008544	biological_process	epidermis development
A	0010820	biological_process	positive regulation of T cell chemotaxis
A	0030216	biological_process	keratinocyte differentiation
A	0031012	cellular_component	extracellular matrix
A	0032496	biological_process	response to lipopolysaccharide
A	0035578	cellular_component	azurophil granule lumen
A	0043542	biological_process	endothelial cell migration
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0050786	molecular_function	RAGE receptor binding
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0071624	biological_process	positive regulation of granulocyte chemotaxis
A	0090026	biological_process	positive regulation of monocyte chemotaxis
A	0140486	molecular_function	zinc ion sequestering activity
B	0000302	biological_process	response to reactive oxygen species
B	0001525	biological_process	angiogenesis
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0008270	molecular_function	zinc ion binding
B	0008544	biological_process	epidermis development
B	0010820	biological_process	positive regulation of T cell chemotaxis
B	0030216	biological_process	keratinocyte differentiation
B	0031012	cellular_component	extracellular matrix
B	0032496	biological_process	response to lipopolysaccharide
B	0035578	cellular_component	azurophil granule lumen
B	0043542	biological_process	endothelial cell migration
B	0046872	molecular_function	metal ion binding
B	0046914	molecular_function	transition metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050786	molecular_function	RAGE receptor binding
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0071624	biological_process	positive regulation of granulocyte chemotaxis
B	0090026	biological_process	positive regulation of monocyte chemotaxis
B	0140486	molecular_function	zinc ion sequestering activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE HO A 102

Chain	Residue
A	ASN64
A	ASP66
A	LYS68
A	GLU73
A	HOH106
A	ASP62

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE HO B 102

Chain	Residue
A	GLU65
B	ASP62
B	ASN64
B	ASP66
B	LYS68
B	GLU73
B	HOH123

---

site_id	HO1
Number of Residues	4
Details	CA2+ BINDING SITE CONTAINING HO3+.

Chain	Residue
A	ASP62
A	ASN64
A	ASP66
A	GLU73

---

site_id	HO2
Number of Residues	4
Details	CA2+ BINDING SITE CONTAINING HO3+.

Chain	Residue
B	ASP62
B	ASN64
B	ASP66
B	GLU73

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKNEDKKIDfsEF

Chain	Residue	Details
A	ASP62-PHE74

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. VFekKDkneDkkiDFsEFlsLL

Chain	Residue	Details
A	VAL57-LEU78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"8526920","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---