1PQE

S25A mutant of pyruvoyl dependent aspartate decarboxylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004068	molecular_function	aspartate 1-decarboxylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006523	biological_process	alanine biosynthetic process
A	0015940	biological_process	pantothenate biosynthetic process
A	0016540	biological_process	protein autoprocessing
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Schiff-base intermediate with substrate; via pyruvic acid","evidences":[{"source":"PubMed","id":"9546220","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor"}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Pyruvic acid (Ser)","evidences":[{"source":"PubMed","id":"9546220","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
A	LYS9

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
A	TYR58

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site_id	MCSA1
Number of Residues	3
Details	M-CSA 409

Chain	Residue	Details
A	LYS9	electrostatic stabiliser
A	ALA25	covalently attached, electrofuge, electrophile
A	TYR58	activator, increase nucleophilicity, proton acceptor, proton donor

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