1PQ8
Trypsin at pH 4 at atomic resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | ARG88 |
| A | VAL183 |
| A | SER184 |
| A | SER185 |
| A | HOH736 |
| A | HOH831 |
| A | HOH859 |
| A | HOH890 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | GLY112 |
| A | GLY113 |
| A | HOH672 |
| A | HOH839 |
| A | HOH913 |
| A | GLN63 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | GLY145 |
| A | SER146 |
| A | SER147 |
| A | SER172 |
| A | HOH678 |
| A | HOH708 |
| A | HOH809 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LYS A 403 |
| Chain | Residue |
| A | SER190 |
| A | CYS191 |
| A | GLN192 |
| A | GLY193 |
| A | SER195 |
| A | VAL210 |
| A | SER211 |
| A | GLY213 |
| A | GLY215 |
| C | GLY2 |
| C | HOH4 |
| C | HOH5 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CIT A 601 |
| Chain | Residue |
| A | ALA22 |
| A | SER23 |
| A | ALA24 |
| A | GLY25 |
| A | ASP26 |
| A | PHE27 |
| A | PRO28 |
| A | ILE30 |
| A | GLY71 |
| A | SER72 |
| A | LEU73 |
| A | ASN114 |
| A | HOH750 |
| A | HOH875 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 223 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for specificity"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | HIS56 | |
| A | ASP99 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | GLY196 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | GLY193 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | HIS56 | |
| A | ASP99 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | GLY193 | |
| A | HIS56 | |
| A | ASP99 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | HIS56 | |
| A | ASP99 | |
| A | GLY196 |
| site_id | CSA7 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | SER211 | |
| A | GLY193 | |
| A | HIS56 | |
| A | ASP99 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 173 |
| Chain | Residue | Details |
| A | HIS56 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ASP99 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | GLN192 | electrostatic stabiliser, hydrogen bond donor, transition state stabiliser |
| A | GLY193 | electrostatic stabiliser, hydrogen bond donor, transition state stabiliser |
| A | ASP194 | electrostatic stabiliser, hydrogen bond donor, transition state stabiliser |
| A | SER195 | electrostatic stabiliser, transition state stabiliser |
