Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1PL7

Human Sorbitol Dehydrogenase (apo)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000721molecular_function(R,R)-butanediol dehydrogenase activity
A0003939molecular_functionL-iditol 2-dehydrogenase (NAD+) activity
A0004022molecular_functionalcohol dehydrogenase (NAD+) activity
A0005615cellular_componentextracellular space
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006060biological_processsorbitol metabolic process
A0006062biological_processsorbitol catabolic process
A0008270molecular_functionzinc ion binding
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019640biological_processD-glucuronate catabolic process to D-xylulose 5-phosphate
A0030246molecular_functioncarbohydrate binding
A0030317biological_processflagellated sperm motility
A0031514cellular_componentmotile cilium
A0031966cellular_componentmitochondrial membrane
A0042802molecular_functionidentical protein binding
A0046370biological_processfructose biosynthetic process
A0046526molecular_functionD-xylulose reductase activity
A0046872molecular_functionmetal ion binding
A0050255molecular_functionribitol 2-dehydrogenase (NAD+) activity
A0051160biological_processxylitol catabolic process
A0051164biological_processxylitol metabolic process
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
B0000721molecular_function(R,R)-butanediol dehydrogenase activity
B0003939molecular_functionL-iditol 2-dehydrogenase (NAD+) activity
B0004022molecular_functionalcohol dehydrogenase (NAD+) activity
B0005615cellular_componentextracellular space
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006006biological_processglucose metabolic process
B0006060biological_processsorbitol metabolic process
B0006062biological_processsorbitol catabolic process
B0008270molecular_functionzinc ion binding
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0019640biological_processD-glucuronate catabolic process to D-xylulose 5-phosphate
B0030246molecular_functioncarbohydrate binding
B0030317biological_processflagellated sperm motility
B0031514cellular_componentmotile cilium
B0031966cellular_componentmitochondrial membrane
B0042802molecular_functionidentical protein binding
B0046370biological_processfructose biosynthetic process
B0046526molecular_functionD-xylulose reductase activity
B0046872molecular_functionmetal ion binding
B0050255molecular_functionribitol 2-dehydrogenase (NAD+) activity
B0051160biological_processxylitol catabolic process
B0051164biological_processxylitol metabolic process
B0051287molecular_functionNAD binding
B0070062cellular_componentextracellular exosome
C0000721molecular_function(R,R)-butanediol dehydrogenase activity
C0003939molecular_functionL-iditol 2-dehydrogenase (NAD+) activity
C0004022molecular_functionalcohol dehydrogenase (NAD+) activity
C0005615cellular_componentextracellular space
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006006biological_processglucose metabolic process
C0006060biological_processsorbitol metabolic process
C0006062biological_processsorbitol catabolic process
C0008270molecular_functionzinc ion binding
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0019640biological_processD-glucuronate catabolic process to D-xylulose 5-phosphate
C0030246molecular_functioncarbohydrate binding
C0030317biological_processflagellated sperm motility
C0031514cellular_componentmotile cilium
C0031966cellular_componentmitochondrial membrane
C0042802molecular_functionidentical protein binding
C0046370biological_processfructose biosynthetic process
C0046526molecular_functionD-xylulose reductase activity
C0046872molecular_functionmetal ion binding
C0050255molecular_functionribitol 2-dehydrogenase (NAD+) activity
C0051160biological_processxylitol catabolic process
C0051164biological_processxylitol metabolic process
C0051287molecular_functionNAD binding
C0070062cellular_componentextracellular exosome
D0000721molecular_function(R,R)-butanediol dehydrogenase activity
D0003939molecular_functionL-iditol 2-dehydrogenase (NAD+) activity
D0004022molecular_functionalcohol dehydrogenase (NAD+) activity
D0005615cellular_componentextracellular space
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006006biological_processglucose metabolic process
D0006060biological_processsorbitol metabolic process
D0006062biological_processsorbitol catabolic process
D0008270molecular_functionzinc ion binding
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0019640biological_processD-glucuronate catabolic process to D-xylulose 5-phosphate
D0030246molecular_functioncarbohydrate binding
D0030317biological_processflagellated sperm motility
D0031514cellular_componentmotile cilium
D0031966cellular_componentmitochondrial membrane
D0042802molecular_functionidentical protein binding
D0046370biological_processfructose biosynthetic process
D0046526molecular_functionD-xylulose reductase activity
D0046872molecular_functionmetal ion binding
D0050255molecular_functionribitol 2-dehydrogenase (NAD+) activity
D0051160biological_processxylitol catabolic process
D0051164biological_processxylitol metabolic process
D0051287molecular_functionNAD binding
D0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 402
ChainResidue
ACYS44
AHIS69
AGLU70
AGLU155
AHOH1952
site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 402
ChainResidue
BHOH1951
BCYS44
BHIS69
BGLU70
BGLU155
site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN C 402
ChainResidue
CCYS44
CHIS69
CGLU70
CGLU155
CHOH1950
site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN D 402
ChainResidue
DCYS44
DHIS69
DGLU70
DGLU155
DHOH1949
Functional Information from PROSITE/UniProt
site_idPS00059
Number of Residues15
DetailsADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaSGTvekvGssV
ChainResidueDetails
AGLY68-VAL82
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12962626","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PL7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PL8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P07846","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12962626","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PL8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qlh
ChainResidueDetails
ASER46
AHIS49
site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qlh
ChainResidueDetails
BSER46
BHIS49
site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qlh
ChainResidueDetails
CSER46
CHIS49
site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qlh
ChainResidueDetails
DSER46
DHIS49

243911

PDB entries from 2025-10-29

PDB statisticsPDBj update infoContact PDBjnumon