1PK9
Crystal Structure of E. coli purine nucleoside phosphorylase complexed with 2-fluoroadenosine and sulfate/phosphate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006152 | biological_process | purine nucleoside catabolic process |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0009164 | biological_process | nucleoside catabolic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0042278 | biological_process | purine nucleoside metabolic process |
B | 0003824 | molecular_function | catalytic activity |
B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
B | 0006152 | biological_process | purine nucleoside catabolic process |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0009164 | biological_process | nucleoside catabolic process |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0042278 | biological_process | purine nucleoside metabolic process |
C | 0003824 | molecular_function | catalytic activity |
C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
C | 0005829 | cellular_component | cytosol |
C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
C | 0006152 | biological_process | purine nucleoside catabolic process |
C | 0009116 | biological_process | nucleoside metabolic process |
C | 0009164 | biological_process | nucleoside catabolic process |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0016763 | molecular_function | pentosyltransferase activity |
C | 0042278 | biological_process | purine nucleoside metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 A 309 |
Chain | Residue |
A | GLY20 |
A | ARG43 |
A | ARG87 |
A | GLY89 |
A | SER90 |
A | 2FA306 |
A | HOH328 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 B 310 |
Chain | Residue |
B | GLY89 |
B | SER90 |
B | 2FA307 |
B | HOH339 |
C | ARG43 |
B | GLY20 |
B | ARG87 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 C 311 |
Chain | Residue |
B | ARG43 |
C | GLY20 |
C | ARG24 |
C | ARG87 |
C | GLY89 |
C | SER90 |
C | 2FA308 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 2FA A 306 |
Chain | Residue |
A | HIS4 |
A | ARG43 |
A | MET64 |
A | ARG87 |
A | SER90 |
A | CYS91 |
A | GLY92 |
A | PHE159 |
A | VAL178 |
A | GLU179 |
A | MET180 |
A | GLU181 |
A | ASP204 |
A | PO4309 |
A | HOH356 |
site_id | AC5 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 2FA B 307 |
Chain | Residue |
B | ARG87 |
B | SER90 |
B | CYS91 |
B | GLY92 |
B | PHE159 |
B | VAL178 |
B | GLU179 |
B | MET180 |
B | GLU181 |
B | SER203 |
B | ASP204 |
B | PO4310 |
B | HOH402 |
C | HIS4 |
C | ARG43 |
C | HOH346 |
site_id | AC6 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 2FA C 308 |
Chain | Residue |
B | HIS4 |
B | ARG43 |
B | HOH341 |
C | MET64 |
C | ARG87 |
C | SER90 |
C | CYS91 |
C | GLY92 |
C | PHE159 |
C | VAL178 |
C | GLU179 |
C | MET180 |
C | GLU181 |
C | ASP204 |
C | PO4311 |
C | HOH326 |
Functional Information from PROSITE/UniProt
site_id | PS01232 |
Number of Residues | 16 |
Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiPScSIytkEL |
Chain | Residue | Details |
A | GLY61-LEU76 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01627 |
Chain | Residue | Details |
A | ASP204 | |
B | ASP204 | |
C | ASP204 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12937174 |
Chain | Residue | Details |
A | HIS4 | |
A | ARG43 | |
B | HIS4 | |
B | ARG43 | |
C | HIS4 | |
C | ARG43 |
site_id | SWS_FT_FI3 |
Number of Residues | 15 |
Details | BINDING: in other chain => ECO:0000269|PubMed:12937174 |
Chain | Residue | Details |
A | GLY20 | |
B | SER203 | |
C | GLY20 | |
C | ARG24 | |
C | ARG87 | |
C | GLU179 | |
C | SER203 | |
A | ARG24 | |
A | ARG87 | |
A | GLU179 | |
A | SER203 | |
B | GLY20 | |
B | ARG24 | |
B | ARG87 | |
B | GLU179 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_01627 |
Chain | Residue | Details |
A | ARG217 | |
B | ARG217 | |
C | ARG217 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000255|HAMAP-Rule:MF_01627 |
Chain | Residue | Details |
A | LYS26 | |
B | LYS26 | |
C | LYS26 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a69 |
Chain | Residue | Details |
A | ASP204 | |
A | ARG217 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a69 |
Chain | Residue | Details |
B | ASP204 | |
B | ARG217 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a69 |
Chain | Residue | Details |
C | ASP204 | |
C | ARG217 |