Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1PK8

Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0007269	biological_process	neurotransmitter secretion
A	0008021	cellular_component	synaptic vesicle
B	0005524	molecular_function	ATP binding
B	0007269	biological_process	neurotransmitter secretion
B	0008021	cellular_component	synaptic vesicle
C	0005524	molecular_function	ATP binding
C	0007269	biological_process	neurotransmitter secretion
C	0008021	cellular_component	synaptic vesicle
D	0005524	molecular_function	ATP binding
D	0007269	biological_process	neurotransmitter secretion
D	0008021	cellular_component	synaptic vesicle
E	0005524	molecular_function	ATP binding
E	0007269	biological_process	neurotransmitter secretion
E	0008021	cellular_component	synaptic vesicle
F	0005524	molecular_function	ATP binding
F	0007269	biological_process	neurotransmitter secretion
F	0008021	cellular_component	synaptic vesicle
G	0005524	molecular_function	ATP binding
G	0007269	biological_process	neurotransmitter secretion
G	0008021	cellular_component	synaptic vesicle
H	0005524	molecular_function	ATP binding
H	0007269	biological_process	neurotransmitter secretion
H	0008021	cellular_component	synaptic vesicle

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 817

Chain	Residue
A	GLU373
A	GLU386
A	ATP800

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA B 817

Chain	Residue
B	GLU373
B	GLU386
B	ATP801

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 817

Chain	Residue
C	GLU373
C	GLU386
C	ATP802

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 817

Chain	Residue
D	GLU373
D	GLU386
D	ATP803

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA E 817

Chain	Residue
E	GLU373
E	GLU386
E	ATP804

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA F 817

Chain	Residue
F	GLU373
F	GLU386
F	ATP805

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA G 817

Chain	Residue
G	GLU373
G	GLU386
G	ATP806

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA H 817

Chain	Residue
H	GLU373
H	GLU386
H	ATP807
H	HOH842

site_id	AC9
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ATP A 800

Chain	Residue
A	LYS225
A	VAL267
A	LYS269
A	HIS274
A	SER275
A	GLY276
A	LYS279
A	GLU305
A	PRO306
A	ILE308
A	ASP313
A	ARG328
A	TRP335
A	LYS336
A	THR337
A	ASN338
A	GLU373
A	LEU375
A	GLU386
A	VAL388
A	CA817
A	HOH831
A	HOH859
A	HOH903
A	HOH916
A	HOH935

site_id	BC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ATP B 801

Chain	Residue
B	LYS225
B	VAL267
B	LYS269
B	HIS274
B	SER275
B	GLY276
B	LYS279
B	GLU305
B	PRO306
B	PHE307
B	ILE308
B	ASP313
B	ARG328
B	TRP335
B	LYS336
B	THR337
B	ASN338
B	GLU373
B	LEU375
B	ILE385
B	GLU386
B	VAL388
B	CA817
B	HOH842
B	HOH890
B	HOH900

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP C 802

Chain	Residue
C	LYS225
C	ILE247
C	VAL267
C	LYS269
C	HIS274
C	SER275
C	GLY276
C	LYS279
C	GLU305
C	PRO306
C	PHE307
C	ILE308
C	ARG328
C	TRP335
C	GLU373
C	LEU375
C	GLU386
C	CA817

site_id	BC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ATP D 803

Chain	Residue
D	HIS274
D	SER275
D	GLY276
D	LYS279
D	GLU305
D	PRO306
D	PHE307
D	ILE308
D	ASP313
D	ARG328
D	TRP335
D	LYS336
D	THR337
D	ASN338
D	GLU373
D	LEU375
D	ILE385
D	GLU386
D	CA817
D	HOH869
D	HOH874
D	HOH892
D	LYS225
D	ILE247
D	VAL267
D	LYS269

site_id	BC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ATP E 804

Chain	Residue
E	LYS225
E	ILE247
E	VAL267
E	LYS269
E	HIS274
E	SER275
E	GLY276
E	LYS279
E	GLU305
E	PRO306
E	PHE307
E	ILE308
E	ARG328
E	TRP335
E	LYS336
E	THR337
E	GLU373
E	LEU375
E	GLU386
E	CA817
E	HOH870

site_id	BC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ATP F 805

Chain	Residue
F	LYS225
F	ILE247
F	VAL267
F	LYS269
F	ALA273
F	HIS274
F	SER275
F	GLY276
F	LYS279
F	GLU305
F	PRO306
F	PHE307
F	ILE308
F	ASP313
F	ARG328
F	TRP335
F	LYS336
F	THR337
F	GLU373
F	LEU375
F	GLU386
F	VAL388
F	CA817
F	HOH848

site_id	BC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ATP G 806

Chain	Residue
G	LYS225
G	ILE247
G	VAL267
G	LYS269
G	HIS274
G	SER275
G	GLY276
G	LYS279
G	GLU305
G	PRO306
G	PHE307
G	ILE308
G	ASP313
G	ARG328
G	TRP335
G	LYS336
G	THR337
G	ASN338
G	GLU373
G	LEU375
G	GLU386
G	CA817
G	HOH880
G	HOH885

site_id	BC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ATP H 807

Chain	Residue
H	LYS225
H	ILE247
H	VAL267
H	LYS269
H	HIS274
H	SER275
H	GLY276
H	LYS279
H	GLU305
H	PRO306
H	PHE307
H	ILE308
H	ARG328
H	TRP335
H	GLU373
H	LEU375
H	GLU386
H	VAL388
H	CA817
H	HOH842
H	HOH855

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 818

Chain	Residue
A	HIS217
A	PHE364
A	HOH879
A	HOH902
B	HIS217
B	PHE364

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 819

Chain	Residue
B	ASP120
B	THR124
B	TRP126
B	ARG186
B	HOH896

Functional Information from PROSITE/UniProt

site_id	PS00415
Number of Residues	8
Details	SYNAPSIN_1 Synapsins signature 1. LRRRLSDS

Chain	Residue	Details
A	LEU4-SER11

site_id	PS00416
Number of Residues	11
Details	SYNAPSIN_2 Synapsins signature 2. GHAHSGMGKVK

Chain	Residue	Details
A	GLY271-LYS281

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Phosphoserine; by CaMK1 and PKA => ECO:0000305\|PubMed:10571231

Chain	Residue	Details
A	SER9
B	SER9
C	SER9
D	SER9
E	SER9
F	SER9
G	SER9
H	SER9

site_id	SWS_FT_FI2
Number of Residues	24
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:22673903

Chain	Residue	Details
A	SER39
D	SER39
D	SER62
D	SER67
E	SER39
E	SER62
E	SER67
F	SER39
F	SER62
F	SER67
G	SER39
A	SER62
G	SER62
G	SER67
H	SER39
H	SER62
H	SER67
A	SER67
B	SER39
B	SER62
B	SER67
C	SER39
C	SER62
C	SER67

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:O88935

Chain	Residue	Details
A	TYR312
B	TYR312
C	TYR312
D	TYR312
E	TYR312
F	TYR312
G	TYR312
H	TYR312

site_id	SWS_FT_FI4
Number of Residues	8
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269\|PubMed:10386995, ECO:0000269\|PubMed:12438562

Chain	Residue	Details
A	SER55
B	SER55
C	SER55
D	SER55
E	SER55
F	SER55
G	SER55
H	SER55

site_id	SWS_FT_FI5
Number of Residues	8
Details	CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000305\|PubMed:10386995

Chain	Residue	Details
A	THR56
B	THR56
C	THR56
D	THR56
E	THR56
F	THR56
G	THR56
H	THR56

site_id	SWS_FT_FI6
Number of Residues	8
Details	CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269\|PubMed:10386995, ECO:0000269\|PubMed:12438562

Chain	Residue	Details
A	THR87
B	THR87
C	THR87
D	THR87
E	THR87
F	THR87
G	THR87
H	THR87

site_id	SWS_FT_FI7
Number of Residues	16
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269\|PubMed:12438562

Chain	Residue	Details
A	SER96
E	SER261
F	SER96
F	SER261
G	SER96
G	SER261
H	SER96
H	SER261
A	SER261
B	SER96
B	SER261
C	SER96
C	SER261
D	SER96
D	SER261
E	SER96

site_id	SWS_FT_FI8
Number of Residues	8
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000305\|PubMed:12438562

Chain	Residue	Details
A	SER103
B	SER103
C	SER103
D	SER103
E	SER103
F	SER103
G	SER103
H	SER103

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)