1PJL
Crystal structure of human m-NAD-ME in ternary complex with NAD and Lu3+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004470 | molecular_function | malic enzyme activity |
| A | 0004471 | molecular_function | malate dehydrogenase (decarboxylating) (NAD+) activity |
| A | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006108 | biological_process | malate metabolic process |
| A | 0008948 | molecular_function | oxaloacetate decarboxylase activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 1902031 | biological_process | regulation of NADP metabolic process |
| B | 0004470 | molecular_function | malic enzyme activity |
| B | 0004471 | molecular_function | malate dehydrogenase (decarboxylating) (NAD+) activity |
| B | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0006108 | biological_process | malate metabolic process |
| B | 0008948 | molecular_function | oxaloacetate decarboxylase activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 1902031 | biological_process | regulation of NADP metabolic process |
| C | 0004470 | molecular_function | malic enzyme activity |
| C | 0004471 | molecular_function | malate dehydrogenase (decarboxylating) (NAD+) activity |
| C | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0006090 | biological_process | pyruvate metabolic process |
| C | 0006108 | biological_process | malate metabolic process |
| C | 0008948 | molecular_function | oxaloacetate decarboxylase activity |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051287 | molecular_function | NAD binding |
| C | 1902031 | biological_process | regulation of NADP metabolic process |
| D | 0004470 | molecular_function | malic enzyme activity |
| D | 0004471 | molecular_function | malate dehydrogenase (decarboxylating) (NAD+) activity |
| D | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0006090 | biological_process | pyruvate metabolic process |
| D | 0006108 | biological_process | malate metabolic process |
| D | 0008948 | molecular_function | oxaloacetate decarboxylase activity |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051287 | molecular_function | NAD binding |
| D | 1902031 | biological_process | regulation of NADP metabolic process |
| E | 0004470 | molecular_function | malic enzyme activity |
| E | 0004471 | molecular_function | malate dehydrogenase (decarboxylating) (NAD+) activity |
| E | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005759 | cellular_component | mitochondrial matrix |
| E | 0006090 | biological_process | pyruvate metabolic process |
| E | 0006108 | biological_process | malate metabolic process |
| E | 0008948 | molecular_function | oxaloacetate decarboxylase activity |
| E | 0009055 | molecular_function | electron transfer activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0051287 | molecular_function | NAD binding |
| E | 1902031 | biological_process | regulation of NADP metabolic process |
| F | 0004470 | molecular_function | malic enzyme activity |
| F | 0004471 | molecular_function | malate dehydrogenase (decarboxylating) (NAD+) activity |
| F | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005759 | cellular_component | mitochondrial matrix |
| F | 0006090 | biological_process | pyruvate metabolic process |
| F | 0006108 | biological_process | malate metabolic process |
| F | 0008948 | molecular_function | oxaloacetate decarboxylase activity |
| F | 0009055 | molecular_function | electron transfer activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0051287 | molecular_function | NAD binding |
| F | 1902031 | biological_process | regulation of NADP metabolic process |
| G | 0004470 | molecular_function | malic enzyme activity |
| G | 0004471 | molecular_function | malate dehydrogenase (decarboxylating) (NAD+) activity |
| G | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005759 | cellular_component | mitochondrial matrix |
| G | 0006090 | biological_process | pyruvate metabolic process |
| G | 0006108 | biological_process | malate metabolic process |
| G | 0008948 | molecular_function | oxaloacetate decarboxylase activity |
| G | 0009055 | molecular_function | electron transfer activity |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| G | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0051287 | molecular_function | NAD binding |
| G | 1902031 | biological_process | regulation of NADP metabolic process |
| H | 0004470 | molecular_function | malic enzyme activity |
| H | 0004471 | molecular_function | malate dehydrogenase (decarboxylating) (NAD+) activity |
| H | 0004473 | molecular_function | malate dehydrogenase (decarboxylating) (NADP+) activity |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005759 | cellular_component | mitochondrial matrix |
| H | 0006090 | biological_process | pyruvate metabolic process |
| H | 0006108 | biological_process | malate metabolic process |
| H | 0008948 | molecular_function | oxaloacetate decarboxylase activity |
| H | 0009055 | molecular_function | electron transfer activity |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| H | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0051287 | molecular_function | NAD binding |
| H | 1902031 | biological_process | regulation of NADP metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LU A 604 |
| Chain | Residue |
| A | GLU255 |
| A | ASP256 |
| A | ASP279 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LU B 1604 |
| Chain | Residue |
| B | GLU1255 |
| B | ASP1256 |
| B | ASP1279 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LU C 2604 |
| Chain | Residue |
| C | GLU2255 |
| C | ASP2256 |
| C | ASP2279 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LU D 3604 |
| Chain | Residue |
| D | GLU3255 |
| D | ASP3256 |
| D | ASP3279 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LU E 4604 |
| Chain | Residue |
| E | GLU4255 |
| E | ASP4256 |
| E | ASP4279 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LU F 5604 |
| Chain | Residue |
| F | GLU5255 |
| F | ASP5256 |
| F | ASP5279 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LU G 6604 |
| Chain | Residue |
| G | GLU6255 |
| G | ASP6256 |
| G | ASP6279 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LU H 7604 |
| Chain | Residue |
| H | GLU7255 |
| H | ASP7256 |
| H | ASP7279 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD A 601 |
| Chain | Residue |
| A | ARG165 |
| A | ASN259 |
| A | THR283 |
| A | LEU310 |
| A | ALA312 |
| A | GLY313 |
| A | GLU314 |
| A | ALA315 |
| A | ASP345 |
| A | LYS346 |
| A | VAL392 |
| A | ALA393 |
| A | GLY394 |
| A | ALA395 |
| A | LEU398 |
| A | LEU419 |
| A | SER420 |
| A | ASN421 |
| A | GLY446 |
| A | GLY465 |
| A | ASN467 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NAD A 602 |
| Chain | Residue |
| A | HIS154 |
| A | GLY192 |
| A | ILE193 |
| A | ARG194 |
| A | ARG197 |
| A | ILE479 |
| A | LEU480 |
| A | ARG542 |
| A | TYR552 |
| A | ARG556 |
| site_id | BC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAD B 1601 |
| Chain | Residue |
| B | ASN1259 |
| B | THR1283 |
| B | LEU1310 |
| B | ALA1312 |
| B | GLY1313 |
| B | GLU1314 |
| B | ALA1315 |
| B | ASP1345 |
| B | LYS1346 |
| B | VAL1392 |
| B | ALA1393 |
| B | GLY1394 |
| B | ALA1395 |
| B | LEU1398 |
| B | LEU1419 |
| B | SER1420 |
| B | ASN1421 |
| B | GLY1465 |
| B | ASN1467 |
| B | HOH8059 |
| site_id | BC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE NAD B 1602 |
| Chain | Residue |
| B | HIS1154 |
| B | LYS1156 |
| B | GLY1192 |
| B | ILE1193 |
| B | ARG1194 |
| B | ARG1197 |
| B | ILE1479 |
| B | LEU1480 |
| B | ASN1482 |
| B | ARG1542 |
| B | TYR1552 |
| B | ARG1556 |
| site_id | BC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD C 2601 |
| Chain | Residue |
| C | GLY2394 |
| C | ALA2395 |
| C | LEU2398 |
| C | LEU2419 |
| C | SER2420 |
| C | ASN2421 |
| C | GLY2446 |
| C | GLY2465 |
| C | ASN2467 |
| C | ARG2165 |
| C | ASN2259 |
| C | THR2283 |
| C | LEU2310 |
| C | ALA2312 |
| C | GLY2313 |
| C | GLU2314 |
| C | ALA2315 |
| C | ASP2345 |
| C | LYS2346 |
| C | VAL2392 |
| C | ALA2393 |
| site_id | BC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NAD C 2602 |
| Chain | Residue |
| C | HIS2154 |
| C | GLY2192 |
| C | ILE2193 |
| C | ARG2194 |
| C | ARG2197 |
| C | ILE2479 |
| C | LEU2480 |
| C | ASN2482 |
| C | ARG2542 |
| C | TYR2552 |
| C | ARG2556 |
| site_id | BC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAD D 3601 |
| Chain | Residue |
| D | ARG3165 |
| D | ASN3259 |
| D | THR3283 |
| D | LEU3310 |
| D | GLY3311 |
| D | ALA3312 |
| D | GLY3313 |
| D | GLU3314 |
| D | ALA3315 |
| D | ASP3345 |
| D | LYS3346 |
| D | VAL3392 |
| D | ALA3393 |
| D | GLY3394 |
| D | ALA3395 |
| D | LEU3398 |
| D | LEU3419 |
| D | SER3420 |
| D | ASN3421 |
| D | GLY3446 |
| D | GLY3465 |
| D | ASN3467 |
| site_id | BC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NAD D 3602 |
| Chain | Residue |
| D | HIS3154 |
| D | LYS3156 |
| D | GLY3192 |
| D | ILE3193 |
| D | ARG3194 |
| D | ILE3479 |
| D | LEU3480 |
| D | ARG3542 |
| D | TYR3552 |
| D | ARG3556 |
| site_id | BC8 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAD E 4601 |
| Chain | Residue |
| E | ARG4165 |
| E | ASN4259 |
| E | THR4283 |
| E | LEU4310 |
| E | GLY4311 |
| E | ALA4312 |
| E | GLY4313 |
| E | GLU4314 |
| E | ALA4315 |
| E | PHE4344 |
| E | ASP4345 |
| E | LYS4346 |
| E | VAL4392 |
| E | ALA4393 |
| E | GLY4394 |
| E | ALA4395 |
| E | LEU4398 |
| E | LEU4419 |
| E | SER4420 |
| E | ASN4421 |
| E | GLY4446 |
| E | GLY4465 |
| E | ASN4467 |
| site_id | BC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NAD E 4602 |
| Chain | Residue |
| E | HIS4154 |
| E | LYS4156 |
| E | GLY4192 |
| E | ILE4193 |
| E | ARG4194 |
| E | ARG4197 |
| E | LEU4480 |
| E | ARG4542 |
| E | TYR4552 |
| E | ARG4556 |
| site_id | CC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD F 5601 |
| Chain | Residue |
| F | ARG5165 |
| F | ASN5259 |
| F | THR5283 |
| F | LEU5310 |
| F | GLY5311 |
| F | ALA5312 |
| F | GLY5313 |
| F | GLU5314 |
| F | ALA5315 |
| F | ASP5345 |
| F | LYS5346 |
| F | VAL5392 |
| F | ALA5393 |
| F | GLY5394 |
| F | ALA5395 |
| F | LEU5398 |
| F | LEU5419 |
| F | ASN5421 |
| F | GLY5446 |
| F | GLY5465 |
| F | ASN5467 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NAD F 5602 |
| Chain | Residue |
| F | GLY5192 |
| F | ILE5193 |
| F | ARG5194 |
| F | ARG5197 |
| F | ILE5479 |
| F | LEU5480 |
| F | ARG5542 |
| F | ARG5556 |
| site_id | CC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD G 6601 |
| Chain | Residue |
| G | ARG6165 |
| G | ASN6259 |
| G | THR6283 |
| G | LEU6310 |
| G | GLY6311 |
| G | ALA6312 |
| G | GLY6313 |
| G | GLU6314 |
| G | ALA6315 |
| G | ASP6345 |
| G | LYS6346 |
| G | ALA6393 |
| G | GLY6394 |
| G | ALA6395 |
| G | LEU6398 |
| G | LEU6419 |
| G | SER6420 |
| G | ASN6421 |
| G | GLY6446 |
| G | GLY6465 |
| G | ASN6467 |
| site_id | CC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NAD G 6602 |
| Chain | Residue |
| G | GLY6192 |
| G | ILE6193 |
| G | ARG6194 |
| G | ARG6197 |
| G | ILE6479 |
| G | LEU6480 |
| G | ARG6542 |
| G | TYR6552 |
| G | ARG6556 |
| site_id | CC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAD H 7601 |
| Chain | Residue |
| H | ARG7165 |
| H | THR7283 |
| H | LEU7310 |
| H | GLY7311 |
| H | ALA7312 |
| H | GLY7313 |
| H | GLU7314 |
| H | ALA7315 |
| H | ASP7345 |
| H | LYS7346 |
| H | VAL7392 |
| H | ALA7393 |
| H | ALA7395 |
| H | LEU7398 |
| H | LEU7419 |
| H | ASN7421 |
| H | GLY7446 |
| H | GLY7465 |
| H | ASN7467 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NAD H 7602 |
| Chain | Residue |
| H | ILE7193 |
| H | ARG7194 |
| H | ARG7197 |
| H | ILE7479 |
| H | LEU7480 |
| H | ARG7542 |
| H | TYR7552 |
| H | ARG7556 |
Functional Information from PROSITE/UniProt
| site_id | PS00331 |
| Number of Residues | 17 |
| Details | MALIC_ENZYMES Malic enzymes signature. FnDDiqGTAaVaLAGLL |
| Chain | Residue | Details |
| A | PHE276-LEU292 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:12962632 |
| Chain | Residue | Details |
| A | TYR112 | |
| B | TYR1112 | |
| C | TYR2112 | |
| D | TYR3112 | |
| E | TYR4112 | |
| F | TYR5112 | |
| G | TYR6112 | |
| H | TYR7112 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:12962632 |
| Chain | Residue | Details |
| A | LYS183 | |
| B | LYS1183 | |
| C | LYS2183 | |
| D | LYS3183 | |
| E | LYS4183 | |
| F | LYS5183 | |
| G | LYS6183 | |
| H | LYS7183 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12121650, ECO:0000269|PubMed:12962632 |
| Chain | Residue | Details |
| A | ARG67 | |
| E | ARG4091 | |
| F | ARG5067 | |
| F | ARG5091 | |
| G | ARG6067 | |
| G | ARG6091 | |
| H | ARG7067 | |
| H | ARG7091 | |
| A | ARG91 | |
| B | ARG1067 | |
| B | ARG1091 | |
| C | ARG2067 | |
| C | ARG2091 | |
| D | ARG3067 | |
| D | ARG3091 | |
| E | ARG4067 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12962632 |
| Chain | Residue | Details |
| A | ARG165 | |
| D | ARG3165 | |
| D | ASN3421 | |
| D | ASN3466 | |
| E | ARG4165 | |
| E | ASN4421 | |
| E | ASN4466 | |
| F | ARG5165 | |
| F | ASN5421 | |
| F | ASN5466 | |
| G | ARG6165 | |
| A | ASN421 | |
| G | ASN6421 | |
| G | ASN6466 | |
| H | ARG7165 | |
| H | ASN7421 | |
| H | ASN7466 | |
| A | ASN466 | |
| B | ARG1165 | |
| B | ASN1421 | |
| B | ASN1466 | |
| C | ARG2165 | |
| C | ASN2421 | |
| C | ASN2466 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10700286, ECO:0000269|PubMed:12121650, ECO:0000269|PubMed:12962632 |
| Chain | Residue | Details |
| A | GLU255 | |
| D | GLU3255 | |
| D | ASP3256 | |
| D | ASP3279 | |
| E | GLU4255 | |
| E | ASP4256 | |
| E | ASP4279 | |
| F | GLU5255 | |
| F | ASP5256 | |
| F | ASP5279 | |
| G | GLU6255 | |
| A | ASP256 | |
| G | ASP6256 | |
| G | ASP6279 | |
| H | GLU7255 | |
| H | ASP7256 | |
| H | ASP7279 | |
| A | ASP279 | |
| B | GLU1255 | |
| B | ASP1256 | |
| B | ASP1279 | |
| C | GLU2255 | |
| C | ASP2256 | |
| C | ASP2279 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10700286, ECO:0000269|PubMed:12962632 |
| Chain | Residue | Details |
| A | ASN259 | |
| E | GLY4311 | |
| F | ASN5259 | |
| F | GLY5311 | |
| G | ASN6259 | |
| G | GLY6311 | |
| H | ASN7259 | |
| H | GLY7311 | |
| A | GLY311 | |
| B | ASN1259 | |
| B | GLY1311 | |
| C | ASN2259 | |
| C | GLY2311 | |
| D | ASN3259 | |
| D | GLY3311 | |
| E | ASN4259 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS156 | |
| B | LYS1346 | |
| C | LYS2156 | |
| C | LYS2224 | |
| C | LYS2240 | |
| C | LYS2272 | |
| C | LYS2346 | |
| D | LYS3156 | |
| D | LYS3224 | |
| D | LYS3240 | |
| D | LYS3272 | |
| A | LYS224 | |
| D | LYS3346 | |
| E | LYS4156 | |
| E | LYS4224 | |
| E | LYS4240 | |
| E | LYS4272 | |
| E | LYS4346 | |
| F | LYS5156 | |
| F | LYS5224 | |
| F | LYS5240 | |
| F | LYS5272 | |
| A | LYS240 | |
| F | LYS5346 | |
| G | LYS6156 | |
| G | LYS6224 | |
| G | LYS6240 | |
| G | LYS6272 | |
| G | LYS6346 | |
| H | LYS7156 | |
| H | LYS7224 | |
| H | LYS7240 | |
| H | LYS7272 | |
| A | LYS272 | |
| H | LYS7346 | |
| A | LYS346 | |
| B | LYS1156 | |
| B | LYS1224 | |
| B | LYS1240 | |
| B | LYS1272 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1do8 |
| Chain | Residue | Details |
| A | ASP278 | |
| A | LYS183 | |
| A | TYR112 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1do8 |
| Chain | Residue | Details |
| B | LYS1183 | |
| B | ASP1278 | |
| B | TYR1112 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1do8 |
| Chain | Residue | Details |
| C | ASP2278 | |
| C | LYS2183 | |
| C | TYR2112 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1do8 |
| Chain | Residue | Details |
| D | ASP3278 | |
| D | TYR3112 | |
| D | LYS3183 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1do8 |
| Chain | Residue | Details |
| E | ASP4278 | |
| E | TYR4112 | |
| E | LYS4183 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1do8 |
| Chain | Residue | Details |
| F | TYR5112 | |
| F | LYS5183 | |
| F | ASP5278 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1do8 |
| Chain | Residue | Details |
| G | TYR6112 | |
| G | LYS6183 | |
| G | ASP6278 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1do8 |
| Chain | Residue | Details |
| H | ASP7278 | |
| H | LYS7183 | |
| H | TYR7112 |
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 21 |
| Chain | Residue | Details |
| A | TYR112 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ARG165 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS183 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | GLU255 | metal ligand |
| A | ASP256 | metal ligand |
| A | ASP278 | hydrogen bond acceptor, proton acceptor, proton donor |
| A | ASP279 | metal ligand |
| A | ASN421 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 21 |
| Chain | Residue | Details |
| B | TYR1112 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ARG1165 | electrostatic stabiliser, hydrogen bond donor |
| B | LYS1183 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| B | GLU1255 | metal ligand |
| B | ASP1256 | metal ligand |
| B | ASP1278 | hydrogen bond acceptor, proton acceptor, proton donor |
| B | ASP1279 | metal ligand |
| B | ASN1421 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA3 |
| Number of Residues | 8 |
| Details | M-CSA 21 |
| Chain | Residue | Details |
| C | TYR2112 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | ARG2165 | electrostatic stabiliser, hydrogen bond donor |
| C | LYS2183 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| C | GLU2255 | metal ligand |
| C | ASP2256 | metal ligand |
| C | ASP2278 | hydrogen bond acceptor, proton acceptor, proton donor |
| C | ASP2279 | metal ligand |
| C | ASN2421 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA4 |
| Number of Residues | 8 |
| Details | M-CSA 21 |
| Chain | Residue | Details |
| D | TYR3112 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | ARG3165 | electrostatic stabiliser, hydrogen bond donor |
| D | LYS3183 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| D | GLU3255 | metal ligand |
| D | ASP3256 | metal ligand |
| D | ASP3278 | hydrogen bond acceptor, proton acceptor, proton donor |
| D | ASP3279 | metal ligand |
| D | ASN3421 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA5 |
| Number of Residues | 8 |
| Details | M-CSA 21 |
| Chain | Residue | Details |
| E | TYR4112 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| E | ARG4165 | electrostatic stabiliser, hydrogen bond donor |
| E | LYS4183 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| E | GLU4255 | metal ligand |
| E | ASP4256 | metal ligand |
| E | ASP4278 | hydrogen bond acceptor, proton acceptor, proton donor |
| E | ASP4279 | metal ligand |
| E | ASN4421 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA6 |
| Number of Residues | 8 |
| Details | M-CSA 21 |
| Chain | Residue | Details |
| F | TYR5112 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| F | ARG5165 | electrostatic stabiliser, hydrogen bond donor |
| F | LYS5183 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| F | GLU5255 | metal ligand |
| F | ASP5256 | metal ligand |
| F | ASP5278 | hydrogen bond acceptor, proton acceptor, proton donor |
| F | ASP5279 | metal ligand |
| F | ASN5421 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA7 |
| Number of Residues | 8 |
| Details | M-CSA 21 |
| Chain | Residue | Details |
| G | TYR6112 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| G | ARG6165 | electrostatic stabiliser, hydrogen bond donor |
| G | LYS6183 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| G | GLU6255 | metal ligand |
| G | ASP6256 | metal ligand |
| G | ASP6278 | hydrogen bond acceptor, proton acceptor, proton donor |
| G | ASP6279 | metal ligand |
| G | ASN6421 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA8 |
| Number of Residues | 8 |
| Details | M-CSA 21 |
| Chain | Residue | Details |
| H | TYR7112 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| H | ARG7165 | electrostatic stabiliser, hydrogen bond donor |
| H | LYS7183 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| H | GLU7255 | metal ligand |
| H | ASP7256 | metal ligand |
| H | ASP7278 | hydrogen bond acceptor, proton acceptor, proton donor |
| H | ASP7279 | metal ligand |
| H | ASN7421 | electrostatic stabiliser, hydrogen bond donor |
