1PJC
L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000286 | molecular_function | alanine dehydrogenase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006524 | biological_process | alanine catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042853 | biological_process | L-alanine catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD A 500 |
| Chain | Residue |
| A | SER133 |
| A | ALA237 |
| A | VAL238 |
| A | LEU239 |
| A | VAL266 |
| A | ALA267 |
| A | GLN270 |
| A | ASN299 |
| A | MET300 |
| A | PRO301 |
| A | HOH503 |
| A | ALA136 |
| A | HOH579 |
| A | HOH592 |
| A | GLY174 |
| A | GLY176 |
| A | VAL177 |
| A | VAL178 |
| A | ASP197 |
| A | ILE198 |
| A | SER219 |
Functional Information from PROSITE/UniProt
| site_id | PS00837 |
| Number of Residues | 26 |
| Details | ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. ILGGGvVGteAakmAvGLGAqVqifD |
| Chain | Residue | Details |
| A | ILE172-ASP197 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pjb |
| Chain | Residue | Details |
| A | ASP269 | |
| A | GLU117 | |
| A | LYS74 | |
| A | HIS95 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 67 |
| Chain | Residue | Details |
| A | ARG15 | activator |
| A | LYS74 | activator, electrostatic stabiliser, hydrogen bond donor |
| A | TYR93 | polar/non-polar interaction, steric role |
| A | HIS95 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | GLU117 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | ASP269 | proton acceptor, proton donor |
