1PJB

L-ALANINE DEHYDROGENASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000286	molecular_function	L-alanine dehydrogenase (NAD+) activity
A	0005886	cellular_component	plasma membrane
A	0016491	molecular_function	oxidoreductase activity
A	0042853	biological_process	L-alanine catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00837
Number of Residues	26
Details	ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. ILGGGvVGteAakmAvGLGAqVqifD

Chain	Residue	Details
A	ILE172-ASP197

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	a catalytic site defined by CSA, PubMed 9665169

Chain	Residue	Details
A	ASP269
A	GLU117
A	LYS74
A	HIS95

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site_id	MCSA1
Number of Residues	6
Details	M-CSA 67

Chain	Residue	Details
A	ARG15	activator
A	LYS74	activator, electrostatic stabiliser, hydrogen bond donor
A	TYR93	polar/non-polar interaction, steric role
A	HIS95	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
A	GLU117	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	ASP269	proton acceptor, proton donor

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