1PFX

PORCINE FACTOR IXA

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
L	0005509	molecular_function	calcium ion binding
L	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 0G6 C 301

Chain	Residue
C	HIS57
C	SER214
C	TRP215
C	GLY216
C	GLU219
L	ILE66
C	TYR99
C	PHE174
C	ASP189
C	SER190
C	CYS191
C	GLN192
C	GLY193
C	SER195

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Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDdinsYeCwC

Chain	Residue	Details
L	CYS62-CYS73

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site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EciEEkCsfeearEvfentektne.FW

Chain	Residue	Details
L	CGU17-TRP42

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CwCqvGfeGKnC

Chain	Residue	Details
L	CYS71-CYS82

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site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC

Chain	Residue	Details
C	VAL53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPHV

Chain	Residue	Details
C	ASP189-VAL200

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CwCqvGFegkn....C

Chain	Residue	Details
L	CYS71-CYS82
L	CYS109-CYS124

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site_id	PS01187
Number of Residues	25
Details	EGF_CA Calcium-binding EGF-like domain signature. DgDQCepnp..........Clnggl..CkDdinsYeC

Chain	Residue	Details
L	ASP47-CYS71

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	TYR1
L	ASN2
L	ASP47
L	GLY48
L	GLN50
L	BHD64
L	ASP65

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site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: via 4-carboxyglutamate => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	CGU7
L	CGU40
L	CGU15
L	CGU17
L	CGU20
L	CGU21
L	CGU26
L	CGU27
L	CGU30
L	CGU36

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by factor XIa => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	ARG146

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site_id	SWS_FT_FI4
Number of Residues	11
Details	MOD_RES: 4-carboxyglutamate => ECO:0000250|UniProtKB:P00741, ECO:0000255|PROSITE-ProRule:PRU00463

Chain	Residue	Details
L	CGU7
L	CGU36
L	CGU40
L	CGU15
L	CGU17
L	CGU20
L	CGU21
L	CGU26
L	CGU27
L	CGU30
L	CGU33

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: (3R)-3-hydroxyaspartate => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	BHD64

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00740

Chain	Residue	Details
L	SER68

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	ASP102
C	HIS57

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	SER195
C	GLY196

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site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	SER195
C	GLY193

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site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	ASP102
C	SER195
C	HIS57

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site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	ASP102
C	SER195
C	HIS57
C	GLY196

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site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	ASP102
C	SER195
C	GLY193
C	HIS57

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