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1PFM

PF4-M2 CHIMERIC MUTANT WITH THE FIRST 10 N-TERMINAL RESIDUES OF R-PF4 REPLACED BY THE N-TERMINAL RESIDUES OF THE IL8 SEQUENCE. MODELS 1-15 OF A 27-MODEL SET.

Functional Information from GO Data
ChainGOidnamespacecontents
A0002548biological_processmonocyte chemotaxis
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0006935biological_processchemotaxis
A0006952biological_processdefense response
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0008009molecular_functionchemokine activity
A0008201molecular_functionheparin binding
A0010628biological_processpositive regulation of gene expression
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0016525biological_processnegative regulation of angiogenesis
A0019221biological_processcytokine-mediated signaling pathway
A0030168biological_processplatelet activation
A0030195biological_processnegative regulation of blood coagulation
A0030593biological_processneutrophil chemotaxis
A0030595biological_processleukocyte chemotaxis
A0031093cellular_componentplatelet alpha granule lumen
A0032760biological_processpositive regulation of tumor necrosis factor production
A0042127biological_processregulation of cell population proliferation
A0042832biological_processdefense response to protozoan
A0045236molecular_functionCXCR chemokine receptor binding
A0045347biological_processnegative regulation of MHC class II biosynthetic process
A0045651biological_processpositive regulation of macrophage differentiation
A0045653biological_processnegative regulation of megakaryocyte differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048018molecular_functionreceptor ligand activity
A0048248molecular_functionCXCR3 chemokine receptor binding
A0051873biological_processkilling by host of symbiont cells
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0062023cellular_componentcollagen-containing extracellular matrix
A0070098biological_processchemokine-mediated signaling pathway
A0071222biological_processcellular response to lipopolysaccharide
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0002548biological_processmonocyte chemotaxis
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0006935biological_processchemotaxis
B0006952biological_processdefense response
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0008009molecular_functionchemokine activity
B0008201molecular_functionheparin binding
B0010628biological_processpositive regulation of gene expression
B0010744biological_processpositive regulation of macrophage derived foam cell differentiation
B0016525biological_processnegative regulation of angiogenesis
B0019221biological_processcytokine-mediated signaling pathway
B0030168biological_processplatelet activation
B0030195biological_processnegative regulation of blood coagulation
B0030593biological_processneutrophil chemotaxis
B0030595biological_processleukocyte chemotaxis
B0031093cellular_componentplatelet alpha granule lumen
B0032760biological_processpositive regulation of tumor necrosis factor production
B0042127biological_processregulation of cell population proliferation
B0042832biological_processdefense response to protozoan
B0045236molecular_functionCXCR chemokine receptor binding
B0045347biological_processnegative regulation of MHC class II biosynthetic process
B0045651biological_processpositive regulation of macrophage differentiation
B0045653biological_processnegative regulation of megakaryocyte differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048018molecular_functionreceptor ligand activity
B0048248molecular_functionCXCR3 chemokine receptor binding
B0051873biological_processkilling by host of symbiont cells
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0062023cellular_componentcollagen-containing extracellular matrix
B0070098biological_processchemokine-mediated signaling pathway
B0071222biological_processcellular response to lipopolysaccharide
B2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
C0002548biological_processmonocyte chemotaxis
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0006935biological_processchemotaxis
C0006952biological_processdefense response
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0008009molecular_functionchemokine activity
C0008201molecular_functionheparin binding
C0010628biological_processpositive regulation of gene expression
C0010744biological_processpositive regulation of macrophage derived foam cell differentiation
C0016525biological_processnegative regulation of angiogenesis
C0019221biological_processcytokine-mediated signaling pathway
C0030168biological_processplatelet activation
C0030195biological_processnegative regulation of blood coagulation
C0030593biological_processneutrophil chemotaxis
C0030595biological_processleukocyte chemotaxis
C0031093cellular_componentplatelet alpha granule lumen
C0032760biological_processpositive regulation of tumor necrosis factor production
C0042127biological_processregulation of cell population proliferation
C0042832biological_processdefense response to protozoan
C0045236molecular_functionCXCR chemokine receptor binding
C0045347biological_processnegative regulation of MHC class II biosynthetic process
C0045651biological_processpositive regulation of macrophage differentiation
C0045653biological_processnegative regulation of megakaryocyte differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048018molecular_functionreceptor ligand activity
C0048248molecular_functionCXCR3 chemokine receptor binding
C0051873biological_processkilling by host of symbiont cells
C0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
C0062023cellular_componentcollagen-containing extracellular matrix
C0070098biological_processchemokine-mediated signaling pathway
C0071222biological_processcellular response to lipopolysaccharide
C2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
D0002548biological_processmonocyte chemotaxis
D0005125molecular_functioncytokine activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0006935biological_processchemotaxis
D0006952biological_processdefense response
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
D0008009molecular_functionchemokine activity
D0008201molecular_functionheparin binding
D0010628biological_processpositive regulation of gene expression
D0010744biological_processpositive regulation of macrophage derived foam cell differentiation
D0016525biological_processnegative regulation of angiogenesis
D0019221biological_processcytokine-mediated signaling pathway
D0030168biological_processplatelet activation
D0030195biological_processnegative regulation of blood coagulation
D0030593biological_processneutrophil chemotaxis
D0030595biological_processleukocyte chemotaxis
D0031093cellular_componentplatelet alpha granule lumen
D0032760biological_processpositive regulation of tumor necrosis factor production
D0042127biological_processregulation of cell population proliferation
D0042832biological_processdefense response to protozoan
D0045236molecular_functionCXCR chemokine receptor binding
D0045347biological_processnegative regulation of MHC class II biosynthetic process
D0045651biological_processpositive regulation of macrophage differentiation
D0045653biological_processnegative regulation of megakaryocyte differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048018molecular_functionreceptor ligand activity
D0048248molecular_functionCXCR3 chemokine receptor binding
D0051873biological_processkilling by host of symbiont cells
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0062023cellular_componentcollagen-containing extracellular matrix
D0070098biological_processchemokine-mediated signaling pathway
D0071222biological_processcellular response to lipopolysaccharide
D2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PROSITE/UniProt
site_idPS00471
Number of Residues45
DetailsSMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CqCVkttsq.VrpRhItsLevikaGphCptaQLIatlkngrki.CLD
ChainResidueDetails
ACYS10-ASP54

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
ALYS61
BLYS61
CLYS61
DLYS61

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06765
ChainResidueDetails
ASER26
BSER26
CSER26
DSER26

226707

PDB entries from 2024-10-30

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