1PEN
ALPHA-CONOTOXIN PNI1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| A | 0035792 | cellular_component | host cell postsynaptic membrane |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NH2 A 17 |
| Chain | Residue |
| A | PRO13 |
| A | CYS16 |
Functional Information from PROSITE/UniProt
| site_id | PS60014 |
| Number of Residues | 15 |
| Details | ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCSlPPCAannpDYC |
| Chain | Residue | Details |
| A | CYS2-CYS16 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | Peptide: {"description":"Alpha-conotoxin PnIA","featureId":"PRO_0000044462","evidences":[{"source":"PubMed","id":"8068627","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Region: {"description":"Ser-Xaa-Pro motif, crucial for potent interaction with nAChR","evidences":[{"source":"UniProtKB","id":"P56636","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR; interacts with a hydrophobic pocket between the two alpha-7/CHRNA7 subunits or between the alpha-3 and the beta-2 subunits of alpha-3-beta-2/CHRNA3-CHRNB2 nAChR","evidences":[{"source":"PubMed","id":"10545176","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25101833","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-7/CHRNA7 nAChR","evidences":[{"source":"PubMed","id":"10545176","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"10226369","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Cysteine amide","evidences":[{"source":"PubMed","id":"8068627","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
