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1PEN

ALPHA-CONOTOXIN PNI1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0030550molecular_functionacetylcholine receptor inhibitor activity
A0035792cellular_componenthost cell postsynaptic membrane
A0035821biological_processmodulation of process of another organism
A0090729molecular_functiontoxin activity
A0099106molecular_functionion channel regulator activity
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NH2 A 17
ChainResidue
APRO13
ACYS16

Functional Information from PROSITE/UniProt
site_idPS60014
Number of Residues15
DetailsALPHA_CONOTOXIN Alpha-conotoxin family signature. CCSlPPCAannpDYC
ChainResidueDetails
ACYS2-CYS16

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Important for inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR; interacts with a hydrophobic pocket between the two alpha-7/CHRNA7 subunits or between the alpha-3 and the beta-2 subunits of alpha-3-beta-2/CHRNA3-CHRNB2 nAChR => ECO:0000305|PubMed:10545176, ECO:0000305|PubMed:25101833
ChainResidueDetails
AALA10

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Important for inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-7/CHRNA7 nAChR => ECO:0000305|PubMed:10545176
ChainResidueDetails
AASN11

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10226369
ChainResidueDetails
ATYR15

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Cysteine amide => ECO:0000269|PubMed:8068627
ChainResidueDetails
ACYS16

224004

PDB entries from 2024-08-21

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