Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
A | 0005524 | molecular_function | ATP binding |
A | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PROSITE/UniProt
site_id | PS00089 |
Number of Residues | 23 |
Details | RIBORED_LARGE Ribonucleotide reductase large subunit signature. WlkLrddvmryGIYNqnlQAvpP |
Chain | Residue | Details |
A | TRP566-PRO588 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000250 |
Chain | Residue | Details |
A | LEU387 | |
A | ILE391 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Cysteine radical intermediate => ECO:0000250 |
Chain | Residue | Details |
A | SER389 | |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | PRO162 | |
A | CYS178 | |
A | VAL207 | |
A | LEU387 | |
A | THR589 | |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Important for hydrogen atom transfer => ECO:0000250 |
Chain | Residue | Details |
A | PHE179 | |
A | ASN416 | |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | SITE: Allosteric effector binding |
Chain | Residue | Details |
A | ASN186 | |
A | GLU216 | |
A | ARG223 | |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Important for electron transfer => ECO:0000250 |
Chain | Residue | Details |
A | TYR693 | |
A | ILE694 | |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Interacts with thioredoxin/glutaredoxin => ECO:0000250 |
Chain | Residue | Details |
A | VAL710 | |
A | ALA713 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 3r1r |
Chain | Residue | Details |
A | CYS388 | |
A | CYS415 | |
A | ASN386 | |
A | GLU390 | |
A | CYS178 | |