1PD2

CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000287	molecular_function	magnesium ion binding
1	0001516	biological_process	prostaglandin biosynthetic process
1	0004364	molecular_function	glutathione transferase activity
1	0004667	molecular_function	prostaglandin-D synthase activity
1	0005509	molecular_function	calcium ion binding
1	0005737	cellular_component	cytoplasm
1	0006693	biological_process	prostaglandin metabolic process
1	0009624	biological_process	response to nematode
1	0010269	biological_process	response to selenium ion
1	0016740	molecular_function	transferase activity
1	0016853	molecular_function	isomerase activity
1	0042803	molecular_function	protein homodimerization activity
1	2000255	biological_process	negative regulation of male germ cell proliferation
2	0000287	molecular_function	magnesium ion binding
2	0001516	biological_process	prostaglandin biosynthetic process
2	0004364	molecular_function	glutathione transferase activity
2	0004667	molecular_function	prostaglandin-D synthase activity
2	0005509	molecular_function	calcium ion binding
2	0005737	cellular_component	cytoplasm
2	0006693	biological_process	prostaglandin metabolic process
2	0009624	biological_process	response to nematode
2	0010269	biological_process	response to selenium ion
2	0016740	molecular_function	transferase activity
2	0016853	molecular_function	isomerase activity
2	0042803	molecular_function	protein homodimerization activity
2	2000255	biological_process	negative regulation of male germ cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GSH 1 301

Chain	Residue
1	TYR8
2	ASP97
1	ARG14
1	TRP39
1	LYS43
1	LYS50
1	ILE51
1	GLN63
1	SER64
1	HOH320

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH 2 302

Chain	Residue
1	ASP97
2	TYR8
2	ARG14
2	TRP39
2	LYS43
2	LYS50
2	ILE51
2	GLN63
2	SER64
2	HOH311
2	HOH323

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:9323136

Chain	Residue	Details
1	TYR8
2	GLN63
1	ARG14
1	TRP39
1	GLY49
1	GLN63
2	TYR8
2	ARG14
2	TRP39
2	GLY49

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details

Chain	Residue	Details
1	TRP104
1	TYR8
1	ARG14

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site_id	CSA2
Number of Residues	3
Details

Chain	Residue	Details
2	TRP104
2	TYR8
2	ARG14

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site_id	MCSA1
Number of Residues	3
Details	M-CSA 719

Chain	Residue	Details
1	TYR8	electrostatic stabiliser, modifies pKa
1	ARG14	electrostatic stabiliser
1	TRP104	electrostatic stabiliser, steric role

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site_id	MCSA2
Number of Residues	3
Details	M-CSA 719

Chain	Residue	Details
2	TYR8	electrostatic stabiliser, modifies pKa
2	ARG14	electrostatic stabiliser
2	TRP104	electrostatic stabiliser, steric role

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