1PD2
CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 1 | 0000287 | molecular_function | magnesium ion binding |
| 1 | 0001516 | biological_process | prostaglandin biosynthetic process |
| 1 | 0004364 | molecular_function | glutathione transferase activity |
| 1 | 0004667 | molecular_function | prostaglandin-D synthase activity |
| 1 | 0005509 | molecular_function | calcium ion binding |
| 1 | 0005737 | cellular_component | cytoplasm |
| 1 | 0006693 | biological_process | prostaglandin metabolic process |
| 1 | 0006749 | biological_process | glutathione metabolic process |
| 1 | 0019371 | biological_process | cyclooxygenase pathway |
| 2 | 0000287 | molecular_function | magnesium ion binding |
| 2 | 0001516 | biological_process | prostaglandin biosynthetic process |
| 2 | 0004364 | molecular_function | glutathione transferase activity |
| 2 | 0004667 | molecular_function | prostaglandin-D synthase activity |
| 2 | 0005509 | molecular_function | calcium ion binding |
| 2 | 0005737 | cellular_component | cytoplasm |
| 2 | 0006693 | biological_process | prostaglandin metabolic process |
| 2 | 0006749 | biological_process | glutathione metabolic process |
| 2 | 0019371 | biological_process | cyclooxygenase pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GSH 1 301 |
| Chain | Residue |
| 1 | TYR8 |
| 2 | ASP97 |
| 1 | ARG14 |
| 1 | TRP39 |
| 1 | LYS43 |
| 1 | LYS50 |
| 1 | ILE51 |
| 1 | GLN63 |
| 1 | SER64 |
| 1 | HOH320 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GSH 2 302 |
| Chain | Residue |
| 1 | ASP97 |
| 2 | TYR8 |
| 2 | ARG14 |
| 2 | TRP39 |
| 2 | LYS43 |
| 2 | LYS50 |
| 2 | ILE51 |
| 2 | GLN63 |
| 2 | SER64 |
| 2 | HOH311 |
| 2 | HOH323 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 154 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 236 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9323136","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
