1PBQ
CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH 5,7-DICHLOROKYNURENIC ACID (DCKA) AT 1.90 ANGSTROMS RESOLUTION
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE DK1 A 1001 |
| Chain | Residue |
| A | GLN13 |
| A | HOH1036 |
| A | HOH1047 |
| A | HOH1078 |
| A | HOH1092 |
| A | HOH1111 |
| A | PHE16 |
| A | PHE92 |
| A | PRO124 |
| A | LEU125 |
| A | THR126 |
| A | ARG131 |
| A | TRP223 |
| A | PHE250 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE DK1 B 1002 |
| Chain | Residue |
| B | PHE16 |
| B | PHE92 |
| B | PRO124 |
| B | LEU125 |
| B | THR126 |
| B | ARG131 |
| B | TRP223 |
| B | ASP224 |
| B | HOH1016 |
| B | HOH1029 |
| B | HOH1053 |
| B | HOH1086 |
| B | HOH1184 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:24876489 |
| Chain | Residue | Details |
| A | SER168-GLN188 | |
| A | VAL239-ARG255 | |
| B | SER168-GLN188 | |
| B | VAL239-ARG255 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24876489 |
| Chain | Residue | Details |
| A | VAL189-ILE210 | |
| A | SER233-LEU238 | |
| B | VAL189-ILE210 | |
| B | SER233-LEU238 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:A0A1L8F5J9 |
| Chain | Residue | Details |
| A | GLN211-ALA232 | |
| B | GLN211-ALA232 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:1PB7, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF5, ECO:0007744|PDB:4NF6, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5DEX, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5U8C, ECO:0007744|PDB:5VIH, ECO:0007744|PDB:5VII, ECO:0007744|PDB:5VIJ |
| Chain | Residue | Details |
| A | PRO124 | |
| B | PRO124 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:1PB7, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF5, ECO:0007744|PDB:4NF6, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5DEX, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5U8C, ECO:0007744|PDB:5VIH, ECO:0007744|PDB:5VII, ECO:0007744|PDB:5VIJ |
| Chain | Residue | Details |
| A | ARG131 | |
| A | SER180 | |
| A | ASP224 | |
| B | ARG131 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5, ECO:0007744|PubMed:24090084 |
| Chain | Residue | Details |
| A | ASN48 | |
| B | ASN48 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN79 | |
| A | ASN99 | |
| A | ASN166 | |
| B | ASN79 | |
| B | ASN99 | |
| B | LYS282 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PubMed:24090084 |
| Chain | Residue | Details |
| A | ASN263 |
