1PB8

CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-SERINE AT 1.45 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DSN A 901

Chain	Residue
A	PHE92
A	PRO124
A	THR126
A	ARG131
A	SER179
A	SER180
A	VAL181
A	TRP223
A	ASP224

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	TRANSMEM: Helical => ECO:0000269|PubMed:24876489

Chain	Residue	Details
A	SER168-GLN188
A	VAL239-ARG255

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site_id	SWS_FT_FI2
Number of Residues	26
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24876489

Chain	Residue	Details
A	VAL189-ILE210
A	SER233-LEU238

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site_id	SWS_FT_FI3
Number of Residues	21
Details	INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:A0A1L8F5J9

Chain	Residue	Details
A	GLN211-ALA232

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:1PB7, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF5, ECO:0007744|PDB:4NF6, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5DEX, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5U8C, ECO:0007744|PDB:5VIH, ECO:0007744|PDB:5VII, ECO:0007744|PDB:5VIJ

Chain	Residue	Details
A	PRO124

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site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:1PB7, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF5, ECO:0007744|PDB:4NF6, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5DEX, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5U8C, ECO:0007744|PDB:5VIH, ECO:0007744|PDB:5VII, ECO:0007744|PDB:5VIJ

Chain	Residue	Details
A	ARG131
A	SER180
A	ASP224

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5, ECO:0007744|PubMed:24090084

Chain	Residue	Details
A	ASN48

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site_id	SWS_FT_FI7
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN79
A	ASN99
A	ASN166

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site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PubMed:24090084

Chain	Residue	Details
A	ASN263

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