Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0019082 | biological_process | viral protein processing |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0019082 | biological_process | viral protein processing |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0019082 | biological_process | viral protein processing |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0019082 | biological_process | viral protein processing |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0019082 | biological_process | viral protein processing |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0019082 | biological_process | viral protein processing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2001 |
| Chain | Residue |
| C | THR239 |
| C | GLU240 |
| F | ARG80 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2002 |
| Chain | Residue |
| C | ARG130 |
| C | ASN196 |
| C | HOH2130 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2003 |
| Chain | Residue |
| A | GLY194 |
| A | HOH2054 |
| A | ASN168 |
| A | LEU192 |
| A | GLU193 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2004 |
| Chain | Residue |
| A | ARG130 |
| A | LYS136 |
| A | HOH2051 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2005 |
| Chain | Residue |
| C | ASN168 |
| C | LEU192 |
| C | GLU193 |
| C | GLY194 |
| C | HOH2093 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2006 |
| Chain | Residue |
| B | ASN168 |
| B | LEU192 |
| B | GLU193 |
| B | GLY194 |
| B | HOH2154 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2007 |
| Chain | Residue |
| B | HOH2172 |
| E | ASN168 |
| E | LEU192 |
| E | GLU193 |
| E | GLY194 |
| E | HOH2107 |
| E | HOH2158 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2008 |
| Chain | Residue |
| D | ARG130 |
| D | ASN196 |
| D | HOH2097 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2009 |
| Chain | Residue |
| E | ARG130 |
| E | ASN196 |
| E | HOH2112 |
| E | HOH2185 |
| E | HOH2211 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 2010 |
| Chain | Residue |
| F | ASN168 |
| F | LEU192 |
| F | GLU193 |
| F | GLY194 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2011 |
| Chain | Residue |
| A | GLY214 |
| A | GLU215 |
| A | ARG216 |
| A | TRP217 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2012 |
| Chain | Residue |
| D | ASN168 |
| D | LEU192 |
| D | GLU193 |
| D | GLY194 |
| D | HOH2043 |
| D | HOH2157 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2013 |
| Chain | Residue |
| E | ARG275 |
| E | THR276 |
| E | HOH2106 |
| E | HOH2141 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2015 |
| Chain | Residue |
| D | GLY214 |
| D | ARG216 |
| D | TRP217 |
| D | ARG275 |
| D | HOH2040 |
| D | HOH2169 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2016 |
| Chain | Residue |
| D | ARG275 |
| D | THR276 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2017 |
| Chain | Residue |
| E | ARG61 |
| E | LEU62 |
| E | HIS63 |
| E | HOH2170 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2018 |
| Chain | Residue |
| E | GLY122 |
| E | SER123 |
| F | ARG294 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2019 |
| Chain | Residue |
| B | ILE37 |
| B | PHE102 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2020 |
| Chain | Residue |
| C | MET6 |
| C | ARG294 |
| D | ALA115 |
| D | SER123 |
| D | HOH2067 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2021 |
| Chain | Residue |
| A | LYS103 |
| A | SER104 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2022 |
| Chain | Residue |
| C | GLY214 |
| C | ARG216 |
| C | TRP217 |
| C | ARG275 |
| C | HOH2089 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 F 2023 |
| Chain | Residue |
| F | ARG61 |
| F | LEU62 |
| F | HIS63 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 2024 |
| Chain | Residue |
| F | ARG130 |
| F | LYS136 |
| F | ASN196 |
| F | HOH2077 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2025 |
| Chain | Residue |
| A | ARG19 |
| A | SER21 |
| A | VAL26 |
| A | SER66 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD A 1001 |
| Chain | Residue |
| A | GLN187 |
| A | PRO188 |
| A | HIS41 |
| A | HIS163 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MRD C 1002 |
| Chain | Residue |
| C | HIS41 |
| C | ILE51 |
| C | HIS163 |
| C | LEU164 |
| C | HOH2128 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MRD D 1003 |
| Chain | Residue |
| D | HIS41 |
| D | THR47 |
| D | HIS163 |
| D | GLN187 |
| D | PRO188 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD E 1004 |
| Chain | Residue |
| E | THR47 |
| E | HIS163 |
| E | LEU164 |
| E | PRO188 |
| site_id | DC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN H OF PHQ-VNSTLQ-CHLOROMETHYLKETONE INHIBITOR |
| Chain | Residue |
| F | HIS41 |
| F | THR47 |
| F | ILE51 |
| F | PHE139 |
| F | CYS144 |
| F | HIS162 |
| F | HIS163 |
| F | LEU164 |
| F | GLU165 |
| F | LEU166 |
| F | GLY167 |
| F | ASP186 |
| F | GLN187 |
| F | PRO188 |
| F | SER189 |
| F | MET190 |
| F | GLN191 |
| site_id | DC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN G OF PHQ-VNSTLQ-CHLOROMETHYLKETONE INHIBITOR |
| Chain | Residue |
| B | HIS41 |
| B | ILE51 |
| B | PHE139 |
| B | ILE140 |
| B | CYS144 |
| B | HIS162 |
| B | HIS163 |
| B | LEU164 |
| B | GLU165 |
| B | LEU166 |
| B | GLY167 |
| B | ASP186 |
| B | GLN187 |
| B | PRO188 |
| B | SER189 |
| B | MET190 |
| B | GLN191 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2bx4 |
| Chain | Residue | Details |
| A | CYS144 | |
| A | HIS41 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2bx4 |
| Chain | Residue | Details |
| B | CYS144 | |
| B | HIS41 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2bx4 |
| Chain | Residue | Details |
| C | CYS144 | |
| C | HIS41 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2bx4 |
| Chain | Residue | Details |
| D | CYS144 | |
| D | HIS41 | |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2bx4 |
| Chain | Residue | Details |
| E | CYS144 | |
| E | HIS41 | |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2bx4 |
| Chain | Residue | Details |
| F | CYS144 | |
| F | HIS41 | |
1P9U
